Monocyte phenotype and cytokine production profiles are dysregulated by short-duration spaceflight

Aviation Space and Environmental Medicine

Volumn 82, Issue 9, 2011, Pages 857-862

  Crucian, Brian ^a   Stowe, Raymond ^b   Quiriarte, Heather ^c   Pierson, Duane ^a   Sams, Clarence ^a  

^a NASA JOHNSON SPACE CENTER   (United States)

^b Microgen Laboratories   (United States)

^c JES Tech/Bioastronautics   (United States)

Author keywords

Gravity; Immune system; Innate immunity

Indexed keywords

L SELECTIN;

ARTICLE; BLOOD; FEMALE; GRANULOCYTE; HUMAN; IMMUNE SYSTEM; IMMUNOCOMPETENCE; IMMUNOLOGY; IMMUNOMAGNETIC SEPARATION; IMMUNOPHENOTYPING; LYMPHOCYTE; MALE; MIDDLE AGED; MONOCYTE; PHENOTYPE; SPACE FLIGHT; WEIGHTLESSNESS;

FEMALE; GRANULOCYTES; HUMANS; IMMUNE SYSTEM; IMMUNOCOMPETENCE; IMMUNOMAGNETIC SEPARATION; IMMUNOPHENOTYPING; L-SELECTIN; LYMPHOCYTES; MALE; MIDDLE AGED; MONOCYTES; PHENOTYPE; SPACE FLIGHT; WEIGHTLESSNESS;

EID: 80053314100     PISSN: 00956562     EISSN: None     Source Type: Journal    
DOI: 10.3357/ASEM.3047.2011     Document Type: Article

References (36)

1. Antoniades CG, Berry PA, Davies ET, Hussain M, Bernal W, et al. Reduced monocyte HLA-DR expression: a novel biomarker of disease severity and outcome in acetaminophen-induced acute liver failure. Hepatology 2006;44:34-43.
2. ++ monocytes are a major source of TNF. J Immunol 2002;168:3536-42.
3. Benjamini Y, Krieger AM, Yekutieli D. Adaptive linear step-up procedures that control the false discovery rate. Biometrika 2006;93:491-507.
4. Boonyaratanakornkit JB, Cogoli A, Li CF, Schopper T, Pippia P, et al. Key gravity-sensitive signaling pathways drive T cell activation. FASEB J 2005;19:2020-2.
5. Borchers AT, Keen CL, Gershwin ME. Microgravity and immune responsiveness: implications for space travel. Nutrition 2002;18:889-98.
6. Buravkova LB, Rykova MP, Grigorieva V, Antropova EN. Cell interactions in microgravity: cytotoxic effects of natural killer cells in vitro. J Gravit Physiol 2004;11:P177-80.
7. Chapes SK, Morrison DR, Guikema JA, Lewis ML, Spooner BS. Production and action of cytokines in space. Adv Space Res 1994;14:5-9.
8. Cogoli A. The effect of space flight on human cellular immunity. Environ Med 1993;37:107-16.
9. Cogoli A, Bechler B, Cogoli-Greuter M, Criswell SB, Joller H, et al. Mitogenic signal transduction in T lymphocytes in microgravity. J Leukoc Biol 1993;53:569-75.
10. Crucian BE, Cubbage ML, Sams CF. Altered cytokine production by specific human peripheral blood cell subsets immediately following space flight. J Interferon Cytokine Res 2000;20:547-56.
11. Crucian B, Lee P, Stowe R, Jones J, Effenhauser R, et al. Immune system changes during simulated planetary exploration on Devon Island, high arctic. BMC Immunol 2007;8:7.
12. Crucian BE, Stowe RP, Pierson DL, Sams CF. Immune system dysregulation following short- vs long-duration spaceflight. Aviat Space Environ Med 2008;79:835-43.
13. Crucian B, Sams C. Immune system dysregulation during spaceflight: clinical risk for exploration-class missions. J Leukoc Biol 2009;86:1017-8.
14. De Martinis M, Modesti M, Ginaldi L. Phenotypic and functional changes of circulating monocytes and polymorphonuclear leucocytes from elderly persons. Immunol Cell Biol 2004;82:415-20.
15. Gmunder FK, Konstantinova I, Cogoli A, Lesnyak A, Bogomolov W, Grachov AW. Cellular immunity in cosmonauts during long duration spaceflight on board the orbital MIR station. Aviat Space Environ Med 1994;65:419-23.
16. Grove DS, Pishak SA, Mastro AM. The effect of a 10-day space flight on the function, phenotype, and adhesion molecule expression of splenocytes and lymph node lymphocytes. Exp Cell Res 1995;219:102-9.
17. Gueguinou N, Huin-Schohn C, Bascove M, Bueb JL, Tschirhart E, et al. Could space flight-associated immune system weakening preclude the expansion of human presence beyond Earth's orbit? J Leukoc Biol 2009;86:1027-38.
18. Haveman JW, van den Berg AP, Verhoeven EL, Nijsten MW, van den Dungen JJ, et al. HLA-DR expression on monocytes and systemic inflammation in patients with ruptured abdominal aortic aneurysms. Crit Care 2006;10:R119.
19. Kaur I, Simons ER, Castro VA, Mark Ott C, Pierson DL. Changes in neutrophil functions in astronauts. Brain Behav Immun 2004;18:443-50.
20. Kaur I, Simons ER, Castro VA, Ott CM, Pierson DL. Changes in monocyte functions of astronauts. Brain Behav Immun 2005;19:547-54.
21. Kaur I, Simons ER, Kapadia AS, Ott CM, Pierson DL. Effect of spaceflight on ability of monocytes to respond to endotoxins of gram-negative bacteria. Clin Vaccine Immunol 2008;15:1523-8.
22. Konstantinova IV, Rykova M, Meshkov D, Peres C, Husson D, Schmitt DA. Natural killer cells after ALTAIR mission. Acta Astronaut 1995;36:713-8.
23. Kuhns DB, Alvord WG, Gallin JI. Increased circulating cytokines, cytokine antagonists, and E-selectin after intravenous administration of endotoxin in humans. J Infect Dis 1995;171:145-52.
24. Meehan RT, Neale LS, Kraus ET, Stuart CA, Smith ML, et al. Alteration in human mononuclear leucocytes following space flight. Immunology 1992;76:491-7.
25. Mehta SK, Stowe RP, Feiveson AH, Tyring SK, Pierson DL. Reactivation and shedding of cytomegalovirus in astronauts during spaceflight. J Infect Dis 2000;182:1761-4.
26. Meshkov D, Rykova M. The natural cytotoxicity in cosmonauts on board space stations. Acta Astronaut 1995;36:719-26.
27. Mills PJ, Meck JV, Waters WW, D'Aunno D, Ziegler MG. Peripheral leukocyte subpopulations and catecholamine levels in astronauts as a function of mission duration. Psychosom Med 2001;63:886-90.
28. Mobley JL, Leininger M, Madore S, Baginski TJ, Renkiewicz R. Genetic evidence of a functional monocyte dichotomy. Inflammation 2007;30:189-97.
29. Nash PV, Konstantinova IV, Fuchs BB, Rakhmilevich AL, Lesnyak AT, Mastro AM. Effect of spaceflight on lymphocyte proliferation and interleukin-2 production. J Appl Physiol 1992;73(2, Suppl.)186S-90S.
30. Pierson DL, Stowe RP, Phillips TM, Lugg DJ, Mehta SK Epstein-Barr virus shedding by astronauts during space flight. Brain Behav Immun 2005;19:235-42.
31. Schwarzenberg M, Pippia P, Meloni MA, Cossu G, Cogoli-Greuter M, Cogoli A. Signal transduction in T lymphocytes-a comparison of the data from space, the free fall machine and the random positioning machine. Adv Space Res 1999; 24:793-800.
32. Sonnenfeld G. Effect of space flight on cytokine production. Acta Astronaut 1994;33:143-7.
33. Sonnenfeld G, Shearer WT. Immune function during space flight. Nutrition 2002;18:899-903.
34. Stowe RP, Sams CF, Mehta SK, Kaur I, Jones ML, et al. Leukocyte subsets and neutrophil function after short-term spaceflight. J Leukoc Biol 1999;65:179-86.
35. Stowe RP, Mehta SK, Ferrando AA, Feeback DL, Pierson DL. Immune responses and latent herpes virus reactivation in spaceflight. Aviat Space Environ Med 2001;72:884-91
36. Stowe RP, Sams CF, Pierson DL. Effects of mission duration on neuroimmune responses in astronauts. Aviat Space Environ Med 2003;74:1281-4.