Protective role of Withaferin-A on immunoexpression of p53 and bcl-2 in 7,12-dimethylbenz(a)anthracene-induced experimental oral carcinogenesis

Investigational New Drugs

Volumn 27, Issue 5, 2009, Pages 447-452

  Panjamurthy, Kuppusamy ^a   Manoharan, Shanmugam ^a   Nirmal, Madhavan Ramados ^a   Vellaichamy, Lakshmanan ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Bcl 2; DMBA; Hamster buccal mucosa; P53; Withaferin A

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; PROTEIN BNIP3; PROTEIN P53; WITHAFERIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER PREVENTION; CARCINOGENESIS; CHEEK POUCH; CONTROLLED STUDY; DISEASE MODEL; HISTOPATHOLOGY; MALE; MOUTH CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; SYRIAN HAMSTER;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; CARCINOGENS; CARCINOMA, SQUAMOUS CELL; CRICETINAE; DISEASE MODELS, ANIMAL; ERGOSTEROL; HUMANS; MALE; MESOCRICETUS; MOLECULAR STRUCTURE; MOUTH NEOPLASMS; PHYTOTHERAPY; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 70349237324     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-008-9199-z     Document Type: Article

References (27)

1. Notani PN (2000) Epidemiology and prevention of head and neck cancer: a global view. In: Saranth D (ed) Contemporary issues in oral cancer. Oxford University Press, New Delhi, pp 1-29
2. E Vairaktaris S Spyridonidou V Papakosta A Vylliotis A Lazaris D Perrea C Yapijakis E Patsouris 2008 The hamster model of sequential oral oncogenesis Oral Oncol 44 315 324 18061531 10.1016/j.oraloncology.2007.08.015 1:CAS:528:DC%2BD1cXjtl2qsL8%3D
3. Goulart Filho JAV, Weega Nonaka CF, Costa Miguel MCD, Almeida Freitas RD, Galvao HC (2008) Immunoexpression of cyclooxygenase-2 and p53 in oral squamous cell carcinoma. Am J Otolaryngol (Article in Press)
4. RM Nagler H Kerner D Laufer S Ben-Eliezer I Minkov O Ben-Itzhak 2002 Squamous cell carcinoma of the tongue: the prevalence and prognostic roles of p53, bcl-2, c-erbB-2 and apoptotic rate as related to clinical and pathological characteristics in a retrospective study Cancer Lett 186 137 150 12213283 10.1016/S0304-3835(02)00265-3 1:CAS:528:DC%2BD38Xms1yhsr0%3D (Pubitemid 35246199)
5. AF de Aguiar Jr LP Kowalski OP de Almeida 2007 Clinicopathological and immunohistochemical evaluation of oral squamous cell carcinoma in patients with early local recurrence Oral Oncol 43 593 601 17070093 10.1016/j.oraloncology. 2006.07.003 (Pubitemid 46856268)
6. IB Gimenz-Conti M LaBate F Liu E Osterndorff 1996 p53 alterations in chemically induced cheek pouch lesions Mol Carcinog 16 197 202 10.1002/(SICI)1098-2744(199608)16:4<197::AID-MC3>3.0.CO;2-D (Pubitemid 26301040)
7. KW Chang SC Lin S Koos K Pather D Solt 1996 p53 and Ha-ras mutations in chemically induced hamster buccal pouch carcinomas Carcinogenesis 17 595 600 8631150 10.1093/carcin/17.3.595 1:CAS:528:DyaK28XhslGisrY%3D (Pubitemid 26085344)
8. K Kato S Kawashiri K Yoshizawa H Kitahara E Yamamoto 2008 Apoptosis-associated markers and clinical outcome in human oral squamous cell carcinoma J Oral Pathol Med 37 364 371 18410312
9. R Kummoona S Mohammad Sami I Al-Kapptan H Al-Muala 2008 Study of anti-apoptotic gene of oral carcinoma by using bcl-2 oncogene J Oral Pathol Med 37 345 351 18248353
10. J Sing KP Gupta 2008 Inositol hexaphosphate induces apoptosis by coordinative modulation of p53, bcl-2 and sequential activation of caspases in 7,12-dimethylbenz[a]anthracene exposed mouse epidermis J Environ Pathol Toxicol Oncol 27 209 217
11. D Ravi K Ramadas BS Mathew KR Panikkar MK Nair MR Pillai 2001 Apoptosis, angiogenesis and proliferation: trifunctional measure of tumour response to radiotherapy for oral cancer Oral Oncol 37 164 171 11167144 10.1016/S1368- 8375(00)00082-8 1:STN:280:DC%2BD38%2FivVansQ%3D%3D (Pubitemid 32146663)
12. R Mohan HJ Hammers P Bargagna-Mohan XH Zhan CJ Herbstritt A Ruiz L Zhang AD Hanson BP Conner J Rougas VS Pribluda 2004 Withaferin-A is a potent inhibitor of angiogenesis Angiogenesis 7 115 122 15516832 10.1007/s10456-004-1026-3 1:CAS:528:DC%2BD2cXptFegu7w%3D (Pubitemid 39491728)
13. M Winters 2006 Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology Altern Med Rev 11 269 277 17176166
14. SK Bhattacharya KS Satyan S Ghosal 1997 Antioxidant activity of glycocwithanolides from Withania somnifera Indian J Exp Biol 35 236 239 9332168 1:CAS:528:DyaK2sXjs1Ghsb0%3D
15. K Panjamurthy S Manoharan VP Menon MR Nirmal N Senthil 2008 Protective role of Withaferin-A on 7,12-dimethylbenz(a)anthracene-induced genotoxicity in bone marrow of Syrian golden hamsters J Biochem Mol Toxicol 22 251 258 18752311 10.1002/jbt.20235 1:CAS:528:DC%2BD1cXhtV2rsbbN
16. SS Subramanian PD Sethi 1969 Withaferin-A from Withania somnifera coagulants roots Curr Sci India 38 267 268 1:CAS:528:DyaF1MXksVKlur4%3D
17. G Shklar 1999 Development of experimental oral carcinogenesis and its impact on current oral cancer research J Dent Res 78 1768 1772 10598904 10.1177/00220345990780120101 1:STN:280:DC%2BD3c%2FmsF2lsQ%3D%3D
18. K Nakagawa K Yamamura S Maeda M Ichihashi 1994 Bcl-2 expression in epidermal keratinocytic diseases Cancer 74 1720 1724 8082073 10.1002/1097-0142(19940915)74:6<1720::AID-CNCR2820740613>3.0.CO;2-T 1:STN:280:DyaK2czmtlKhuw%3D%3D (Pubitemid 24301825)
19. D Ravi KR Nalinakumari RS Rajaram MK Nair MR Pillai 1996 Expression of programmed cell death regulatory p53 and bcl-2 protiens in oral lesions Cancer Lett 105 139 146 8697436 10.1016/0304-3835(96)04258-9 1:CAS:528: DyaK28XksF2gs7o%3D (Pubitemid 26252585)
20. Y Legros P McIntyre T Soussi 1992 The cDNA cloning and immunological characterization of hamster p53 Gene 112 247 250 1555773 10.1016/0378-1119(92) 90384-2 1:CAS:528:DyaK38Xks1GjsLY%3D
21. G Gasparini N Weidner S Maluta F Pozza P Boracchi M Mezzetti A Testolin P Bevilacqua 1993 Intratumoral microvessel density and p53 protein: correlation with metastasis in head and neck squamous cell carcinoma Int J Cancer 55 739 744 8244569 10.1002/ijc.2910550507 1:STN:280:DyaK2c%2FmsVWmuw%3D%3D (Pubitemid 23354886)
22. M Hollstein D Sidransky B Vogelstein CC Harris 1991 p53 mutations in human cancers Science 253 5015 49 53 1905840 10.1126/science.1905840 1:CAS:528:DyaK3MXks1Gmurg%3D
23. J Kaur A Srivastava R Ralhan 1994 Overexpression of p53 protein in betal and tobacco related human oral dysplasia and squamous cell carcinoma in India Int J Cancer 58 340 345 8050814 10.1002/ijc.2910580305 1:CAS:528: DyaK2cXlslakt7o%3D (Pubitemid 24254640)
24. RC Jordan GC Catzavelos AW Barrett PM Speight 1996 Differential expression of bcl-2 and bax in squamous cell carcinomas of the oral cavity Oral Oncol Eur J Cancer 32B 394 400 10.1016/S0964-1955(96)00033-4 1:STN:280:DyaK2s7ptFaltw%3D%3D (Pubitemid 27023567)
25. K Kannan PN Latha G Shanmugam 1998 Expression of bcl-2 oncoprotein in Indian oral squamous cell carcinomas Oral Oncol 34 373 376 9861342 10.1016/S1368-8375(98)00037-2 1:CAS:528:DyaK1cXmtlCmsr0%3D (Pubitemid 28440298)
26. C Kuropkat TK Venkatesan DD Caldarelli WR Panje J Hutchinson HD Perisler JS Coon JA Werner 2002 Abnormalities of molecular regulators of proliferation and apoptosis in carcinoma of the oral cavity and oropharynx Auris Nasus Larynx 29 165 174 11893452 10.1016/S0385-8146(01)00129-8 (Pubitemid 34230368)
27. T Miyashita S Krajewski M Krajewska HG Wang HK Lin DA Liebermann B Hoffman JC Reed 1994 Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo Oncogene 9 1799 1805 8183579 1:CAS:528:DyaK2cXkslCqurc%3D