Impact of extractables/leachables from filters on stability of protein formulations

Journal of Pharmaceutical Sciences

Volumn 100, Issue 11, 2011, Pages 4617-4630

  Huang, Min ^a   Horwitz, Teresa S ^b   Zweiben, Cindy ^a   Singh, Satish K ^a  

^a PFIZER INC   (United States)

^b Saint Louis University School of Science and Engineering   (United States)

Author keywords

Extractables; Filter membrane; Filtration; Leachables; Protein aggregation; Protein formulation; Proteins; Stability; Surfactants

Indexed keywords

CHEMICAL COMPOUND; IMMUNOGLOBULIN G2; MIXED CELLULOSE ESTER; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY IMMUNOGLOBULIN G2; NYLON; POLYCARBONATE; POLYETHERSULFONE; POLYSORBATE 80; POLYVINYLIDENE FLUORIDE; SURFACTANT; UNCLASSIFIED DRUG;

ACIDITY; AQUEOUS SOLUTION; ARTICLE; BIOFILTRATION; CONTROLLED STUDY; HIGH THROUGHPUT SCREENING; MEMBRANE FILTER; OXIDATION; PREFORMULATION; PROTEIN AGGREGATION; PROTEIN STABILITY; SURFACE TENSION; TEMPERATURE STRESS;

EID: 80053292218     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22670     Document Type: Article

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