Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 20, 2011, Pages 6135-6142

  Vardanyan, Ruben ^a   Kumirov, Vlad K ^a   Nichol, Gary S ^a   Davis, Peg ^b   Liktor Busa, Erika ^b   Rankin, David ^b   Varga, Eva ^b   Vanderah, Todd ^b   Porreca, Frank ^b   Lai, Josephine ^b   Hruby, Victor J ^a  

^a University of Arizona   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Opioids; Analgesic; Bivalent ligands; Fentanyl; NK1 antagonist

Indexed keywords

2 [2 OXO 2 [(1 PHENETHYLPIPERIDIN 4 YL)(PHENYL)AMINO]ETHOXY]ACETIC ACID; 3,5 BIS(TRIFLUOROMETHYL)BENZYL 3 (1H INDOL 3 YL) 2 [2 [2 OXO 2 [(1 PHENETHYLPIPERIDIN 4 YL)(PHENYL)AMINO]ETHOXY]ACETAMIDO]PROPANOATE; 3,5 BIS(TRIFLUOROMETHYL)BENZYL 3 (1H INDOL 3 YL) 2 [4 OXO 4 [(1 PHENETHYLPIPERIDIN 4 Y)(PHENYL)AMINO]BUTANAMIDO]PROPANOATE; 3,5 BIS(TRIFLUOROMETHYL)BENZYL 3 (1H INDOL 3 YL) 2 [5 OXO 5 [(1 PHENETHYLPIPERIDIN 4 YL)(PHENYL)AMINO]PENTANAMIDO]PROPANOATE; 3,5 BIS(TRIFLUOROMETHYL)BENZYL ESTER TRYPTOPHAN; 4 OXO 4 [(1 PHENETHYLPIPERIDIN 4 YL)(PHENYL)AMINO]BUTANOIC ACID; 5 OXO 5 [(1 PHENETHYLPIPERIDIN 4 YL)(PHENYL)AMINO]PENTANOIC ACID; NEUROKININ 1 RECEPTOR ANTAGONIST; OPIATE AGONIST; UNCLASSIFIED DRUG;

ADDITION REACTION; ANIMAL TISSUE; ARTICLE; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSFORMATION; MALE; MOUSE; NONHUMAN;

ANALGESICS, OPIOID; ANIMALS; BINDING SITES; DRUG DESIGN; GUINEA PIGS; HUMANS; LIGANDS; MALE; MICE; MICE, INBRED ICR; RECEPTORS, NEUROKININ-1;

EID: 80053290724     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.08.027     Document Type: Article

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