Spinal antinociceptive effects of AA501, a novel chimeric peptide with opioid receptor agonist and tachykinin receptor antagonist moieties

European Journal of Pharmacology

Volumn 488, Issue 1-3, 2004, Pages 91-99

  Bonney, Iwona Maszczynska ^a,b,c   Foran, Stacy E ^a,b   Marchand, James E ^a,b   Lipkowski, Andrzej W ^a,c   Carr, Daniel B ^a  

^a TUFTS MEDICAL CENTER   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

Author keywords

(Rat); Antinociception; Neuropathic pain; Novel chimeric peptide; Opioids; Substance P

Indexed keywords

AA 501; ANTINOCICEPTIVE AGENT; CHIMERIC PROTEIN; FORMALDEHYDE; N' (TYROSYL DEXTRO ALANYLGLYCYLPHENYLALANINE) N'' BENZYLOXYCARBONYLTRYPTOPHAN; OPIATE AGONIST; SUBSTANCE P ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; NEUROPATHIC PAIN; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TAIL FLICK TEST;

ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; CATHETERIZATION; DRUG TOLERANCE; FORMALDEHYDE; INDOLES; INJECTIONS, SPINAL; MALE; OLIGOPEPTIDES; PAIN MEASUREMENT; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; RECEPTORS, NEUROKININ-1; RECEPTORS, OPIOID; RECEPTORS, OPIOID, MU; RECEPTORS, TACHYKININ; RECOMBINANT FUSION PROTEINS;

EID: 1642398888     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.02.023     Document Type: Article

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