Application of the systematic "DAmP" approach to create a partially defective C. albicans mutant

Fungal Genetics and Biology

Volumn 48, Issue 11, 2011, Pages 1056-1061

  Finkel, J S ^a   Yudanin, N ^a   Nett, J E ^b   Andes, D R ^b   Mitchell, A P ^a  

^a CARNEGIE MELLON UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Biofilm; Candida albicans; DAmP; SUN41

Indexed keywords

MEMBRANE PROTEIN; PROTEIN SUN41; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; BIOFILM; CANDIDA ALBICANS; CELL ADHESION; CELL MEMBRANE PERMEABILITY; CELL MIGRATION; CONTROLLED STUDY; DAMP ALLELE; FUNGUS MUTANT; GENE ACTIVITY; GENE FUNCTION; GENE SEQUENCE; GENE TARGETING; GENETIC ANALYSIS; GENETIC CODE; GENETIC COMPLEMENTATION; GENETIC DISORDER; GENETIC MODEL; IN VIVO STUDY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SACCHAROMYCES CEREVISIAE;

CANDIDA ALBICANS; GENE KNOCKDOWN TECHNIQUES; GENES, FUNGAL; MYCOLOGY;

CANDIDA ALBICANS; SACCHAROMYCES CEREVISIAE;

EID: 80053284824     PISSN: 10871845     EISSN: 10960937     Source Type: Journal    
DOI: 10.1016/j.fgb.2011.07.005     Document Type: Article

References (40)

1. Abramoff M.D., Magelhaes P.J., Ram S.J. Image processing with ImageJ. Biophotonics Int. 2004, 11:36-42.
2. Alby K., et al. Homothallic and heterothallic mating in the opportunistic pathogen Candida albicans. Nature 2009, 460:890-893.
3. Andes D., et al. Development and characterization of an in vivo central venous catheter Candida albicans biofilm model. Infect. Immun. 2004, 72:6023-6031.
4. Backen A.C., et al. Evaluation of the CaMAL2 promoter for regulated expression of genes in Candida albicans. Yeast 2000, 16:1121-1129.
5. Bastidas R.J., et al. The protein kinase Tor1 regulates adhesin gene expression in Candida albicans. PLoS Pathog. 2009, 5:e1000294.
6. Blankenship J.R., et al. An extensive circuitry for cell wall regulation in Candida albicans. PLoS Pathog. 2010, 6:e1000752.
7. Brodsky J.L., Schekman R. A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposome. J. Cell Biol. 1993, 123:1355-1363.
8. Bruno V.M., et al. Control of the C. albicans cell wall damage response by transcriptional regulator Cas5. PLoS Pathog. 2006, 2:e21.
9. Care R.S., et al. The MET3 promoter: a new tool for Candida albicans molecular genetics. Mol. Microbiol. 1999, 34:792-798.
10. Cowen L.E., Lindquist S. Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science 2005, 309:2185-2189.
11. Davis D.A., et al. Candida albicans Mds3p, a conserved regulator of pH responses and virulence identified through insertional mutagenesis. Genetics 2002, 162:1573-1581.
12. Devasahayam G., et al. The Ess1 prolyl isomerase is required for growth and morphogenetic switching in Candida albicans. Genetics 2002, 160:37-48.
13. Epp E., et al. Forward genetics in Candida albicans that reveals the Arp2/3 complex is required for hyphal formation, but not endocytosis. Mol. Microbiol. 2010, 75:1182-1198.
14. Fang H.M., Wang Y. RA domain-mediated interaction of Cdc35 with Ras1 is essential for increasing cellular cAMP level for Candida albicans hyphal development. Mol. Microbiol. 2006, 61:484-496.
15. Firon A., et al. The SUN41 and SUN42 genes are essential for cell separation in Candida albicans. Mol. Microbiol. 2007, 66:1256-1275.
16. Fu Y., et al. Gene overexpression/suppression analysis of candidate virulence factors of Candida albicans. Eukaryot. Cell. 2008, 7:483-492.
17. Hiller E., et al. Candida albicans Sun41p, a putative glycosidase, is involved in morphogenesis, cell wall biogenesis, and biofilm formation. Eukaryot. Cell. 2007, 6:2056-2065.
18. Homann O.R., et al. A phenotypic profile of the Candida albicans regulatory network. PLoS Genet. 2009, 5:e1000783.
19. Kennedy M.A., et al. Cloning and sequencing of the Candida albicans C-4 sterol methyl oxidase gene (ERG25) and expression of an ERG25 conditional lethal mutation in Saccharomyces cerevisiae. Lipids 2000, 35:257-262.
20. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
21. Muhlrad D., Parker R. Aberrant mRNAs with extended 3' UTRs are substrates for rapid degradation by mRNA surveillance. RNA 1999, 5:1299-1307.
22. Nakayama H., et al. Tetracycline-regulatable system to tightly control gene expression in the pathogenic fungus Candida albicans. Infect. Immun. 2000, 68:6712-6719.
23. Nett J., et al. Putative role of beta-1, 3 glucans in Candida albicans biofilm resistance. Antimicrob. Agents Chemother. 2007, 51:510-520.
24. Nobile C.J., Mitchell A.P. Regulation of cell-surface genes and biofilm formation by the C. albicans transcription factor Bcr1p. Curr. Biol. 2005, 15:1150-1155.
25. Norice, C.T., 2008. Studies of Candida albicans Sun41 function and regulation. Thesis (Ph.D), Columbia University, New York.
26. Norice C.T., et al. Requirement for Candida albicans Sun41 in biofilm formation and virulence. Eukaryot. Cell. 2007, 6:2046-2055.
27. Oh, J., et al., 2010. Gene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collection. PLoS Pathog. 6.
28. Park Y.N., Morschhauser J. Tetracycline-inducible gene expression and gene deletion in Candida albicans. Eukaryot. Cell. 2005, 4:1328-1342.
29. Pfaller M.A., Diekema D.J. Epidemiology of invasive candidiasis: a persistent public health problem. Clin. Microbiol. Rev. 2007, 20:133-163.
30. Rex J.H., et al. Practice guidelines for the treatment of candidiasis. Infectious Diseases Society of America. Clin. Infect. Dis. 2000, 30:662-678.
31. Roemer T., et al. Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery. Mol. Microbiol. 2003, 50:167-181.
32. Soll D.R., et al. Relationship between switching and mating in Candida albicans. Eukaryot. Cell. 2003, 2:390-397.
33. Spreghini E., et al. Roles of Candida albicans Dfg5p and Dcw1p cell surface proteins in growth and hypha formation. Eukaryot. Cell. 2003, 2:746-755.
34. Towbin H., et al. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 1979, 76:4350-4354.
35. Uhl M.A., et al. Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C. albicans. EMBO J. 2003, 22:2668-2678.
36. Watanabe H., et al. Analysis of chitin at the hyphal tip of Candida albicans using calcofluor white. Biosci. Biotechnol. Biochem. 2005, 69:1798-1801.
37. Xu D., et al. Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans. PLoS Pathog. 2007, 3:e92.
38. Yan Z., et al. Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers. Nat. Methods 2008, 5:719-725.
39. Zacchi L.F., et al. Mds3 regulates morphogenesis in Candida albicans through the TOR pathway. Mol. Cell Biol. 2010, 30:3695-3710.
40. Zhao X., et al. Analysis of the Candida albicans Als2p and Als4p adhesins suggests the potential for compensatory function within the Als family. Microbiology 2005, 151:1619-1630.