Defining the anatomical localisation of subsets of the murine mononuclear phagocyte system using integrin alpha X (Itgax, CD11c) and colony stimulating factor 1 receptor (Csf1r, CD115) expression fails to discriminate dendritic cells from macrophages

Immunobiology

Volumn 216, Issue 11, 2011, Pages 1228-1237

  Bradford, Barry M ^a   Sester, David P ^a   Hume, David A ^a   Mabbott, Neil A ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Colony stimulating factor 1 receptor; Dendritic cell; Inate immunity; Integrin alpha X; Macrophage; Mononuclear phagocyte hematopoeisis

Indexed keywords

COLONY STIMULATING FACTOR 1 RECEPTOR; COLONY STIMULATING FACTOR RECEPTOR; GLYCOPROTEIN P 15095; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL LINEAGE; CELL POPULATION; CELL SUBPOPULATION; CONTROLLED STUDY; DENDRITIC CELL; GERMINAL CENTER; HEMATOPOIETIC CELL; LAMINA PROPRIA; LUNG PARENCHYMA; LYMPHOID ORGAN; MACROPHAGE; MONOCYTE; MONONUCLEAR PHAGOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTIGENS, CD11C; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL LINEAGE; DENDRITIC CELLS; GENE EXPRESSION; IMMUNITY, INNATE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; INTESTINES; LUNG; LYMPH NODES; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MICE; MICE, TRANSGENIC; MONOCYTES; MUCOUS MEMBRANE; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR;

EID: 80053277573     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2011.08.006     Document Type: Article

References (59)

1. Ammon C., Meyer S.P., Schwarzfischer L., Krause S.W., Andreesen R., Kreutz M. Comparative analysis of integrin expression on monocyte-derived macrophages and monocyte-derived dendritic cells. Immunology 2000, 100:364.
2. Annacker O., Coombes J.L., Malmstrom V., Uhlig H.H., Bourne T., Johansson-Lindbom B., Agace W.W., Parker C.M., Powrie F. Essential role for CD103 in the T cell-mediated regulation of experimental colitis. J. Exp. Med. 2005, 202:1051.
3. Ansel K.M., Ngo V.N., Hyman P.L., Luther S.A., Forster R., Sedgwick J.D., Browning J.L., Lipp M., Cyster J.G. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 2000, 406:309.
4. 3CR1 in their response to inflammation. J. Exp. Med. 2009, 206:595.
5. Bar-On L., Jung S. Defining in vivo dendritic cell functions using CD11c-DTR transgenic mice. Methods in Molecular Biology: Dendritic Cell Protocols 2010, vol. 595. Shalin H. Naik, NY, p. 429. 2nd edition.
6. Barchet W., Krug A., Cella M., Newby C., Fischer J.A.A., Dzionek A., Pekosz A., Colonna M. Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways. Eur. J. Immunol. 2005, 35:236.
7. Belz G.T., Smith C.M., Kleinert L., Reading P., Brooks A., Shortman K., Carbone F.R., Heath W.R. Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:8670.
8. Birnberg T., Bar-On L., Sapoznikov A., Caton M.L., Cervantes-Barragán L., Makia D., Krauthgamer R., Brenner O., Ludewig B., Brockschnieder D., Riethmacher D., Reizis B., Jung S. Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome. Immunity 2008, 29:986.
9. Carlsen H.S., Baekkevold E.S., Johansen F.E., Haraldsen G., Brandtzaeg P. B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue. Gut 2002, 51:364.
10. - dendritic cells in the spleen. J. Exp. Med. 2007, 204:1653.
11. Chung Y., Chang J.-H., Kim B.-S., Lee J.-M., Kim H.-Y., Kang C.-Y. Anatomic location defines antigen presentation by dendritic cells to T cells in response to intravenous soluble antigens. Eur. J. Immunol. 2007, 37:1453.
12. Crocker P.R., Gordon S. Properties and distribution of a lectin-like hemagglutinin differentially expressed by murine stromal tissue macrophages. J. Exp. Med. 1986, 164:1862.
13. - dendritic cells with distinct functional properties. J. Immunol. 2008, 181:6178.
14. - dendritic cells cross-prime cytotoxic T cells in vivo. J. Exp. Med. 2000, 192:1685.
15. Denning T.L., Wang Y.-c., Patel S.R., Williams I.R., Pulendran B. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat. Immunol. 2007, 8:1086.
16. Dziennis S., Van Etten R., Pahl H., Morris D., Rothstein T., Blosch C., Perlmutter R., Tenen D. The CD11b promoter directs high-level expression of reporter genes in macrophages in transgenic mice. Blood 1995, 85:319.
17. Edwards A.D., Chaussabel D., Tomlinson S., Schulz O., Sher A., Reis e Sousa C. Relationships among murine CD11chigh dendritic cell subsets as revealed by baseline gene expression patterns. J. Immunol. 2003, 171:47.
18. Fleeton M.N., Contractor N., Leon F., Wetzel J.D., Dermody T.S., Kelsall B.L. Peyer's patch dendritic cells process viral antigen from apoptotic epithelial cells in the intestine of reovirus-infected mice. J. Exp. Med. 2004, 200:235.
19. Garceau V., Smith J., Paton I.R., Davey M., Fares M.A., Sester D.P., Burt D.W., Hume D.A. Pivotal advance: avian colony-stimulating factor 1 (CSF-1), interleukin-34 (IL-34), and CSF-1 receptor genes and gene products. J. Leukoc. Biol. 2010, 87:753.
20. Geissmann F., Manz M.G., Jung S., Sieweke M.H., Merad M., Ley K. Development of monocytes, macrophages, and dendritic cells. Science 2010, 327:656.
21. GeurtsvanKessel C.H., Willart M.A.M., Bergen I.M., van Rijt L.S., Muskens F., Elewaut D., Osterhaus A.D.M.E., Hendriks R., Rimmelzwaan G.F., Lambrecht B.N. Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice. J. Exp. Med. 2009, 206:2339.
22. Gonzalez-Juarrero M., Shim T.S., Kipnis A., Junqueira-Kipnis A.P., Orme I.M. Dynamics of macrophage cell populations during murine pulmonary tuberculosis. J. Immunol. 2003, 171:3128.
23. Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., Williams L.T. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature 1998, 391:799.
24. Henry R.A., Kendall P.L. CXCL13 blockade disrupts B lymphocyte organization in tertiary lymphoid structures without altering B cell receptor bias or preventing diabetes in nonobese diabetic mice. J. Immunol. 2010, 185:1460.
25. Hume D.A. Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity. J. Leukoc. Biol. 2011, 89:525.
26. Hume D.A. Differentiation and heterogeneity in the mononuclear phagocyte system. Mucosal Immunol. 2008, 1:432.
27. Hume D.A. Macrophages as APC and the dendritic cell myth. J. Immunol. 2008, 181:5829.
28. Hume D.A., Robinson A.P., MacPherson G.G., Gordon S. The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs. J. Exp. Med. 1983, 158:1522.
29. Huynh D., Dai X.-M., Nandi S., Lightowler S., Trivett M., Chan C.-K., Bertoncello I., Ramsay R.G., Stanley E.R. Colony stimulating factor-1 dependence of paneth cell development in the mouse small intestine. Gastroenterology 2009, 137:136.
30. Jang M.H., Sougawa N., Tanaka T., Hirata T., Hiroi T., Tohya K., Guo Z., Umemoto E., Ebisuno Y., Yang B.-G., Seoh J.-Y., Lipp M., Kiyono H., Miyasaka M. CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. J. Immunol. 2006, 176:803.
31. JAX, 2009. Gt(ROSA)26Sortm1Luo, tm2Luo, tm3Luo, tm4ACTB-tdTomato,-EGFP)Luo, Standard PCR http://jaxmice.jax.org/protocolsdb/f%3Fp=116%3A2%3A2783464770572500%3A%3ANO%3A2%3AP2_MASTER_PROTOCOL_ID,P2_JRS_CODE%3A;1;%201143,007576.
32. + T cells by exogenous cell-associated antigens. Immunity 2002, 17:211.
33. Krug A., French A.R., Barchet W., Fischer J.A.A., Dzionek A., Pingel J.T., Orihuela M.M., Akira S., Yokoyama W.M., Colonna M. TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 2004, 21:107.
34. Liu K., Victora G.D., Schwickert T.A., Guermonprez P., Meredith M.M., Yao K., Chu F.-F., Randolph G.J., Rudensky A.Y., Nussenzweig M. In vivo analysis of dendritic cell development and homeostasis. Science 2009, 324:392.
35. Lu C., Takagi J., Springer T.A. Association of the membrane proximal regions of the α and β subunit cytoplasmic domains constrains an integrin in the inactive state. J. Biol. Chem. 2001, 276:14642.
36. MacDonald K.P.A., Palmer J.S., Cronau S., Seppanen E., Olver S., Raffelt N.C., Kuns R., Pettit A.R., Clouston A., Wainwright B., Branstetter D., Smith J., Paxton R.J., Cerretti D.P., Bonham L., Hill G.R., Hume D.A. An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation. Blood 2010, 116:3955.
37. MacDonald K.P.A., Rowe V., Bofinger H.M., Thomas R., Sasmono T., Hume D.A., Hill G.R. The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion. J. Immunol. 2005, 175:1399.
38. McDonald K.G., McDonough J.S., Dieckgraefe B.K., Newberry R.D. Dendritic cells produce CXCL13 and participate in the development of murine small intestine lymphoid tissues. Am. J. Pathol. 2010, 176:2367.
39. McLellan A.D., Kapp M., Eggert A., Linden C., Bommhardt U., Brocker E.-B., Kammerer U., Kampgen E. Anatomic location and T-cell stimulatory functions of mouse dendritic cell subsets defined by CD4 and CD8 expression. Blood 2002, 99:2084.
40. Metlay J.P., Witmer-Pack M.D., Agger R., Crowley M.T., Lawless D., Steinman R.M. The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J. Exp. Med. 1990, 171:1753.
41. Mooney J.E., Rolfe B.E., Osborne G.W., Sester D.P., van Rooijen N., Campbell G.R., Hume D.A., Campbell J.H. Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response. Am. J. Pathol. 2010, 176:369.
42. Muzumdar M.D., Tasic B., Miyamichi K., Li L., Luo L. A global double-fluorescent Cre reporter mouse. Genesis 2007, 45:593.
43. 3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 2005, 307:254.
44. Ohnmacht C., Pullner A., King S.B.S., Drexler I., Meier S., Brocker T., Voehringer D. Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J. Exp. Med. 2009, 206:549.
45. Onai N., Manz M.G., Schmid M.A. Isolation of common dendritic cell progenitors (CDP) from mouse bone marrow. Methods in Molecular Biology: Dendritic Cell Protocols 2010, vol. 595. Shalin H Naik, NY, pp. 195-203. 2nd edition.
46. + plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat. Immunol. 2007, 8:1207.
47. Pavli P., Woodhams C.E., Doe W.F., Hume D.A. Isolation and characterization of antigen-presenting dendritic cells from the mouse intestinal lamina propria. Immunology 1990, 70:40.
48. + dendritic cells. J. Immunol. 2001, 166:5327.
49. Sadhu C., Ting H.J., Lipsky B., Hensley K., Garcia-Martinez L.F., Simon S.I., Staunton D.E. CD11c/CD18: novel ligands and a role in delayed-type hypersensitivity. J. Leukoc. Biol. 2007, 81:1395.
50. +,T cells by plasmacytoid dendritic cells. J. Exp. Med. 2007, 204:1923.
51. Sasmono R.T., Oceandy D., Pollard J.W., Tong W., Pavli P., Wainwright B.J., Ostrowski M.C., Himes S.R., Hume D.A. A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood 2003, 101:1155.
52. +, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J. Exp. Med. 2009, 206:3101.
53. Sengupta A., Liu W.K., Yeung Y.G., Yeung D.C., Frackelton A.R., Stanley E.R. Identification and subcellular localization of proteins that are rapidly phosphorylated in tyrosine in response to colony-stimulating factor 1. Proc. Natl. Acad. Sci. U.S.A. 1988, 85:8062.
54. + dendritic cell subset. Immunol. Rev. 2010, 234:18.
55. Springer T., Galfré G., Secher D.S., Milstein C. Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur. J. Immunol. 1979, 9:301.
56. Stanley E.R. Action of the colony-stimulating factor, CSF-1. Ciba found. Symp. Biochem. Macrophages 1986, 118:29-41.
57. Stanley E.R., Guilbert L.J., Tushinski R.J., Bartelmez S.H. CSF-1 - a mononuclear phagocyte lineage-specific hemopoietic growth factor. J. Cell. Biochem. 1983, 21:151.
58. Veiga-Fernandes H., Coles M.C., Foster K.E., Patel A., Williams A., Natarajan D., Barlow A., Pachnis V., Kioussis D. Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis. Nature 2007, 446:547.
59. Yu P., Wang Y., Chin R.K., Martinez-Pomares L., Gordon S., Kosco-Vibois M.H., Cyster J., Fu Y.-X. B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion. J. Immunol. 2002, 168:5117.