Autoimmunity against cardiac troponin i in ischaemia reperfusion injury

European Journal of Heart Failure

Volumn 13, Issue 10, 2011, Pages 1052-1059

  Volz, H Christian ^a   Buss, Sebastian J ^a   Li, Jin ^a   Göser, Stefan ^a   Andrassy, Martin ^a   Öttl, Renate ^a   Pfitzer, Gabriele ^b   Katus, Hugo A ^a   Kaya, Ziya ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Autoimmunity; Cardiac troponin; Ischaemia; Myocardial infarction; Reperfusion injury

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR5; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10; INTERLEUKIN 2; LYMPHOTAXIN; MACROPHAGE INFLAMMATORY PROTEIN 1; RANTES; T CELL ACTIVATION GENE 3 PROTEIN; TROPONIN I; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY TITER; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; CORONARY ARTERY LIGATION; CYTOKINE PRODUCTION; ECHOCARDIOGRAPHY; FEMALE; HEART INFARCTION; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REVASCULARIZATION; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY;

ANIMALS; AUTOIMMUNITY; DISEASE MODELS, ANIMAL; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; MICE; MYOCARDIAL INFARCTION; REAL-TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; RNA, MESSENGER; TROPONIN I;

EID: 80053270028     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1093/eurjhf/hfr098     Document Type: Article

References (24)

1. Okazaki T, Tanaka Y, Nishio R, Mitsuiye T, Mizoguchi A, Wang J, Ishida M, Hiai H, Matsumori A, Minato N, Honjo T. Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice. Nat Med 2003; 12:1477-1483
2. Goser S, Andrassy M, Buss SJ, Leuschner F, Volz CH, Ottl R, Zittrich S, Blaudeck N, Hardt SE, Pfitzer G, Rose NR, Katus HA, Kaya Z. Cardiac troponin I but not cardiac troponin T induces severe autoimmune inflammation in the myocardium. Circulation 2006;16:1693-1702.
3. Kloner RA, Jennings RB. Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: part 1. Circulation 2001;24:2981-2989.
4. Frangogiannis NG. The role of the chemokines in myocardial ischemia and reperfusion. Curr Vasc Pharmacol 2004;2:163-174.
5. Fleming SD. Natural antibodies, autoantibodies and complement activation in tissue injury. Autoimmunity 2006;5:379-386.
6. Linfert D, Chowdhry T, Rabb H. Lymphocytes and ischemia-reperfusion injury. Transplant Rev (Orlando) 2009;1:1-10.
7. Andrassy M, Volz HC, Igwe JC, Funke B, Eichberger SN, Kaya Z, Buss S, Autschbach F, Pleger ST, Lukic IK, Bea F, Hardt SE, Humpert PM, Bianchi ME, Mairbaurl H, Nawroth PP, Remppis A, Katus HA, Bierhaus A. High-mobility group box-1 in ischemia-reperfusion injury of the heart. Circulation 2008;25:3216-3226.
8. Michael LH, Ballantyne CM, Zachariah JP, Gould KE, Pocius JS, Taffet GE, Hartley CJ, Pham TT, Daniel SL, Funk E, Entman ML. Myocardial infarction and remodelling in mice: effect of reperfusion. Am J Physiol 1999;2(Pt 2):H660-H668.
9. Hardt SE, Geng YJ, Montagne O, Asai K, Hong C, Yang GP, Bishop SP, Kim SJ, Vatner DE, Seidman CE, Seidman JG, Homcy CJ, Vatner SF. Accelerated cardiomyopathy in mice with overexpression of cardiac G(s)alpha and a missense mutation in the alpha-myosin heavy chain. Circulation 2002;5:614-620.
10. Piot C, Croisille P, Staat P, Thibault H, Rioufol G, Mewton N, Elbelghiti R, Cung TT, Bonnefoy E, Angoulvant D, Macia C, Raczka F, Sportouch C, Gahide G, Finet G, Andre-Fouet X, Revel D, Kirkorian G, Monassier JP, Derumeaux G, Ovize M. Effect of cyclosporine on reperfusion injury in acute myocardial infarction. N Engl J Med 2008;5:473-481.
11. Xue Y, Clopton P, Peacock WF, Maisel AS. Serial changes in high-sensitive troponin I predict outcome in patients with decompensated heart failure. Eur J Heart Fail 2011;1:37-42.
12. Leuschner F, Li J, Goser S, Reinhardt L, Ottl R, Bride P, Zehelein J, Pfitzer G, Remppis A, Giannitsis E, Katus HA, Kaya Z. Absence of auto-antibodies against cardiac troponin I predicts improvement of left ventricular function after acute myocardial infarction. Eur Heart J 2008;16:1949-1955.
13. Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med 2007;11: 1121-1135.
14. Jager A, Kuchroo VK. Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation. Scand J Immunol 2010;3:173-184.
15. Yang Z, Zingarelli B, Szabo C. Crucial role of endogenous interleukin-10 production in myocardial ischemia/reperfusion injury. Circulation 2000;9: 1019-1026.
16. Ayaz-Guner S, Zhang J, Li L, Walker JW, Ge Y. In vivo phosphorylation site mapping in mouse cardiac troponin I by high resolution top-down electron capture dissociation mass spectrometry: Ser22/23 are the only sites basally phosphorylated. Biochemistry 2009;34:8161-8170.
17. Zhang J, Dong X, Hacker TA, Ge Y. Deciphering modifications in swine cardiac troponin I by top-down high-resolution tandem mass spectrometry. J Am Soc Mass Spectrom 2010;6:940-948.
18. Dungen HD, Platzeck M, Vollert J, Searle J, Muller C, Reiche J, Mehrhof F, Muller R, Mockel M. Autoantibodies against cardiac troponin I in patients with congestive heart failure. Eur J Heart Fail 2010;7:668-675.
19. Felix SB, Staudt A, Dorffel WV, Stangl V, Merkel K, Pohl M, Docke WD, Morgera S, Neumayer HH, Wernecke KD, Wallukat G, Stangl K, Baumann G. Hemodynamic effects of immunoadsorption and subsequent immunoglobulin substitution in dilated cardiomyopathy: three-month results from a randomized study. J Am Coll Cardiol 2000;6:1590-1598.
20. Dorffel WV, Felix SB, Wallukat G, Brehme S, Bestvater K, Hofmann T, Kleber FX, Baumann G, Reinke P. Short-term hemodynamic effects of immunoadsorption in dilated cardiomyopathy. Circulation 1997;8:1994-1997.
21. Heymans S, Hirsch E, Anker SD, Aukrust P, Balligand JL, Cohen-Tervaert JW, Drexler H, Filippatos G, Felix SB, Gullestad L, Hilfiker-Kleiner D, Janssens S, Latini R, Neubauer G, Paulus WJ, Pieske B, Ponikowski P, Schroen B, Schultheiss HP, Tschope C, Van Bilsen M, Zannad F, McMurray J, Shah AM. Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 2009;2:119-129.
22. Jones SP, Trocha SD, Lefer DJ. Cardioprotective actions of endogenous IL-10 are independent of iNOS. Am J Physiol Heart Circ Physiol 2001;1:H48-H52.
23. Giugliano GR, Giugliano RP, Gibson CM, Kuntz RE. Meta-analysis of corticosteroid treatment in acute myocardial infarction. Am J Cardiol 2003;9:1055-1059.
24. Gomez L, Li B, Mewton N, Sanchez I, Piot C, Elbaz M, Ovize M. Inhibition of mitochondrial permeability transition pore opening: translation to patients. Cardiovasc Res 2009;2:226-233.