Potential risks associated with the use of herbal anti-obesity products

Drug Safety

Volumn 32, Issue 6, 2009, Pages 453-456

  Chan, Thomas Y K ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAQUINONE; ANTIARRHYTHMIC AGENT; ANTIOBESITY AGENT; ARISTOLOCHIC ACID; BISACODYL; CAFFEINE; CARDIAC GLYCOSIDE; CASCARA SAGRADA; CORTICOSTEROID; DIURETIC AGENT; EPHEDRA EXTRACT; EPHEDRINE; FENFLURAMINE; HERBACEOUS AGENT; LAXATIVE; N NITROSOFENFLURAMINE; NONSTEROID ANTIINFLAMMATORY AGENT; PHENOLPHTHALEIN; SIBUTRAMINE; THYROID EXTRACT; UNCLASSIFIED DRUG;

ALOE; ARISTOLOCHIA; ARTICLE; BODY WEIGHT; CANCER RISK; COLORECTAL CANCER; DETOXIFICATION; DIET SUPPLEMENTATION; DRUG FATALITY; DRUG LABELING; DRUG MARKETING; DRUG OVERDOSE; DRUG SAFETY; DRUG WITHDRAWAL; EPHEDRA SINICA; GUARANA; HEALTH CARE PERSONNEL; HEART INFARCTION; HEART PALPITATION; HERB DRUG INTERACTION; HERBAL MEDICINE; HUMAN; HYPERTENSION; HYPOKALEMIA; KIDNEY FAILURE; LIVER FAILURE; LIVER TOXICITY; MENTAL DISEASE; NEPHROTOXICITY; OBESITY; PATIENT EDUCATION; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RHUBARB; RISK BENEFIT ANALYSIS; SEIZURE; SENNA; STEPHANIA TETRANDRA; STROKE; TACHYCARDIA; THYROTOXICOSIS; VALVULAR HEART DISEASE; WEIGHT CONTROL;

ANTI-OBESITY AGENTS; DRUG CONTAMINATION; HERB-DRUG INTERACTIONS; HUMANS; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL;

EID: 66249108263     PISSN: 01145916     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002018-200932060-00002     Document Type: Article

References (36)

1. Prentice AM. The emerging epidemic of obesity in developing countries. Int J Epidemiol 2006; 35: 93-9
2. Sharpe PA, Granner ML, Conway JM, et al. Availability of weight-loss supplements: results of an audit of retail outlets in a southeastern city. J Am Diet Assoc 2006; 106: 2045-51
3. Blanck HM, Serdula MK, Gillespie C, et al. Use of non-prescription dietary supplements for weight loss is common among Americans. J Am Diet Assoc 2007; 107: 441-7
4. Heber D. Herbal preparations for obesity: are they useful? Primary Care 2003; 30: 441-63
5. Pittler MH, Schmidt K, Ernst E. Adverse events of herbal food supplements for body weight reduction: systematic review. Obesity Rev 2005; 6: 93-111
6. Chitturi S, Farrell GC. Hepatotoxic slimming aids and other herbal hepatotoxins. J Gastroenterol Hepatol 2008; 23: 366-73
7. National Heart, Lung, and Blood Institute and North American Association for the Study of Obesity. NHLBI obesity education initiative: practical guide to the identification, evaluation and treatment of overweight and obesity in adults. Bethesda (MD): National Institutes of Health, 2000. NIH publication number 98-4084
8. Poon WT, Mak TWL, Chan AYW. Slimming agent-related adversities in Hong Kong. Poisoning Comm 2007; 2 (2): 1-2 [online]. Available from URL: http://www.chp.gov.hk/files/ pdf/grp-poison-en-20070430.pdf [Accessed 2009 Mar 12]
9. Arlt VM, Stiborova M, Schmeiser HH. Aristolochic acid as a probable human cancer hazard in herbal remedies: a review. Mutagenesis 2002; 17: 265-77
10. Debelle FD, Vanherweghem JL, Nortier JL. Aristolochic acid nephropathy: a worldwide problem. Kidney Int 2008; 74: 158-69
11. Wong A, Chan C. Review of adverse events related to Chinese medicines in Hong Kong, July 2004-June 2005. Public Health Epidemiol Bull 2005; 14: 45-51
12. Vanherweghem JL, Depierreux M, Tielemans C, et al. Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet 1993; 341: 387-91
13. Wen YJ, Su T, Tang JW, et al. Cytotoxicity of phenan-threnes extracted from Aristolochia contorta in human proximal tubular epithelial cell line. Nephron Exp Nephrol 2006; 103: e95-102
14. Ioset J-R, Raoelison GE, Hostettmann K. Detection of aristolochic acid in Chinese phytomedicines and dietary supplements used as slimming regimens. Food Chem Toxicol 2003; 41: 29-36
15. Gold LS, Slone TH. Aristolochic acid, an herbal carcinogen, sold on the web after FDA alert [letter]. N Engl J Med 2003; 349: 1576-7
16. Martena MJ, van der Wielen JC, van de Laak LF, et al. Enforcement of the ban on aristolochic acids in Chinese traditional herbal preparations on the Dutch market. Anal Bioanal Chem 2007; 389: 263-75
17. Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000; 343: 1833-8
18. Maglione M, Miotto K, Iguchi M, et al. Psychiatric effects of ephedra use: an analysis of Food and Drug Administration reports of adverse events. Am J Psychiatr 2005; 162: 189-91
19. Li FK, Lai CK, Poon WT, et al. Aggravation of non-steroidal anti-inflammatory drug-induced hepatitis and acute renal failure by slimming drug containing anthra-quinones. Nephrol Dial Transplant 2004; 19: 1916-7
20. Kwan TH, Tong MK, Leung KT, et al. Acute renal failure associated with prolonged intake of slimming pills containing anthraquines. Hong Kong Med J 2006; 12: 394-7
21. Yuen MF, Tam S, Fung J, et al. Traditional Chinese medicine causing hepatotoxicity in patients with chronic hepatitis B infection: a 1-year prospective study. Aliment Pharmacol Ther 2006; 24: 1179-86
22. van Gorkom BA, de Vries EG, Karrenbeld A, et al. An-thranoid laxatives and their potential carcinogenic effects. Aliment Pharmacol Ther 1999; 13: 443-52
23. Hong Kong Consumer Council. A detailed analysis on proprietary cleansing and slimming products. Choice Mag 2001; 301: 12-23
24. European Medicines Agency. Assessment report for rhubarb (Rhei radix). London: EMA, 2008 [online]. Available from URL: http://www.emea.europa.eu/pdfs/ human/ hmpc/rhei-radix/1 8962607en.pdf [Accessed 2009 Mar 12]
25. Keisler BD, Hosey RG. Ergogenic aids: an update on ephedra. Curr Sports Med Rep 2005; 4: 231-5
26. Podrid PJ. Proarrhythmia, a serious complication of anti-arrhythmic drugs. Curr Cardiol Rep 1999; 1: 289-96
27. Roden DM. Drug-induced prolongation of the QT interval. N Engl J Med 2004; 350: 1013-22
28. Wang J, Chen B, Yao S. Analysis of six synthetic adulterants in herbal weight-reducing dietary supplements by LC electro-spray ionization-MS. Food Addit Contam 2008; 25: 822-30
29. Metcalfe K, Corns C, Fahie-Wilson M, et al. Chinese medicines for slimming still cause health problems [letter]. BMJ 2002; 324: 679
30. Chang K, Mak TWL, Kwong L, et al. Valvular heart disease caused by Chinese proprietary slimming medicine adulterated with fenfluramine. Hong Kong J Paediatr 2005; 10: 55-8
31. Dunnick JK, Hailey JR. Phenolphthalein exposure causes multiple carcinogenic effects in experimental model systems. Cancer Res 1996; 56: 4922-6
32. Nakadai A, Inagaki H, Minami M, et al. Determination of the optical purity of N-nitrosofenfluramine found in the Chinese slimming diet. Yakugaku Zasshi 2003; 123: 805-9
33. Adachi M, Saito H, Kobayashi H, et al. Hepatic injury in 12 patients taking the herbal weight loss aids Chaso or On-shido. Ann Intern Med 2003; 139: 488-92
34. Ohye H, Fukata S, Kanoh M, et al. Thyrotoxicosis caused by weight-reducting herbal medicines. Arch Intern Med 2005; 165: 831-4
35. Poon WT, Ng SW, Lai CK, et al. Factitious thyrotoxicosis and herbal dietary supplement for weight reduction. Clin Toxicol 2008; 46: 290-2
36. Anonymous. Thyroid extracts as slimming aids: danger! [editorial]. Prescrire Int 2006; 15: 183