Acute hepatitis induced by an Aloe vera preparation: A case report

World Journal of Gastroenterology

Volumn 11, Issue 2, 2005, Pages 303-304

  Rabe, Christian ^a,c   Musch, Annemarie ^a   Schirmacher, Peter ^b   Kruis, Wolfgang ^a   Hoffman, Robert ^a  

^a Evangelisches Krankenhaus Kalk   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

Acute diseases; Aloe vera; Hepatitis

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALOE VERA EXTRACT; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; GAMMA GLUTAMYLTRANSFERASE; LACTATE DEHYDROGENASE; NON PRESCRIPTION DRUG; ZINC;

ABDOMINAL DISCOMFORT; ACUTE HEPATITIS; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CASE REPORT; DRUG WITHDRAWAL; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HUMAN; HYPERBILIRUBINEMIA; JAUNDICE; LACTATE DEHYDROGENASE BLOOD LEVEL; PRURITUS; TOXIC HEPATITIS;

EID: 12344287967     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v11.i2.303     Document Type: Article

References (17)

1. Logarto Parra A, Yhebra RS, Sardinas IG, Buela LI. Comparative study of the assay of Artemia salina L. and the estimate of the medium lethal dose (LD50 value) in mice, to determine oral acute toxicity of plant extracts. Phytomedicine 2001; 8: 395-400
2. Swanson LN. Therapeutic value of Aloe Vera. US Pharmacist 1995: 26-35
3. Fischer JM. Medical use of aloe products. US Pharmacist 1982; 7: 37-45
4. Syed TA, Ahmad SA, Holt AH, Ahmad SH, Afzal M. Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled, double-blind study. Trop Med Int Health 1996; 1: 505-509
5. Ikeno Y, Hubbard GB, Lee S, Yu BP, Herlihy JT. The influence of long-term Aloe vera ingestion on age-related disease in male Fischer 344 rats. Phytother Res 2002; 16: 712-718
6. Chung JH, Cheong JC, Lee JY, Roh HK, Cha YN. Acceleration of the alcohol oxidation rate in rats with aloin, a quinone derivative of Aloe. Biochem Pharmacol 1996; 52: 1461-1468
7. Avila H, Rivero J, Herrera F, Fraile G. Cytotoxicity of a low molecular weight fraction from Aloe vera (Aloe barbadensis Miller) gel. Toxicon 1997; 35: 1423-1430
8. Mueller SO, Stopper H, Dekant W. Biotransformation of the anthraquinones emodin and chrysophanol by cytochrome P450 enzymes. Bioactivation to genotoxic metabolites. Drug Metab Dispos 1998; 26: 540-546
9. Morrow DM, Rapaport MJ, Strick RA. Hypersensitivity to aloe. Arch Dermatol 1980; 116: 1064-1065
10. Hart LA, van Enckevort PH, van Dijk H, Zaat R, de Silva KT, Labadie RP. Two functionally and chemically distinct immunomodulatory compounds in the gel of Aloe vera. J Ethnopharmacol 1988; 23: 61-71
11. Corsi MM, Bertelli AA, Gaja G, Fulgenzi A, Ferrero ME. The therapeutic potential of Aloe Vera in tumor-bearing rats. Int J Tissue React 1998; 20: 115-118
12. Singh RP, Dhanalakshmi S, Rao AR. Chemomodulatory action of Aloe vera on the profiles of enzymes associated with carcinogen metabolism and antioxidant status regulation in mice. Phytomedicine 2000; 7: 209-219
13. Shamaan NA, Kadir KA, Rahmat A, Ngah WZ. Vitamin C and aloe vera supplementation protects from chemical hepatocarcinogenesis in the rat. Nutrition 1998; 14: 846-852
14. Kim HS, Kacew S, Lee BM. In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor). Carcinogenesis 1999; 20: 1637-1640
15. Arosio B, Gagliano N, Fusaro LM, Parmeggiani L, Tagliabue J, Galetti P, De Castri D, Moscheni C, Annoni G. Aloe-Emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride. Pharmacol Toxicol 2000; 87: 229-233
16. Yagi A, Kabash A, Okamura N, Haraguchi H, Moustafa SM, Khalifa TI. Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera. Planta Med 2002; 68 957-960
17. Yagi A, Kabash A, Mizuno K, Moustafa SM, Khalifa TI, Tsuji H. Radical scavenging glycoprotein inhibiting cyclooxygenase-2 and thromboxane A2 synthase from aloe vera gel. Planta Med 2003; 69 269-271