Pyrazolo[1,5-a]pyrimidines, triazolo[1,5-a]pyrimidines and their tricyclic derivatives as corticotropin-releasing factor 1 (CRF 1) receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 20, 2011, Pages 5955-5966

  Saito, Tetsuji ^a   Obitsu, Tetsuo ^a   Minamoto, Chiaki ^a   Sugiura, Tsuneyuki ^a   Matsumura, Naoya ^a   Ueno, Sonoko ^a   Kishi, Akihiro ^a   Katsumata, Seishi ^a   Nakai, Hisao ^a   Toda, Masaaki ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Antagonist; Corticotrophin releasing factor 1 receptor

Indexed keywords

6 BUTYL N5 (2 CHLORO 4 METHOXYPHENYL) N7,N7 DIPROPYLPYRAZOLO[1,5 A]PYRIMIDINE 5,7 DIAMINE; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; IMIDAZO[1,5 A]PYRIMIDINE DERIVATIVE; N5 (2 CHLORO 4 METHOXYPHENYL) 6 (1 ETHYLPROPYL) N7,N7 DIPROPYL[1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE 5,7 DIAMINE; N5 (2 CHLORO 4 METHOXYPHENYL) 6 CYCLOPENTYL N7,N7 DIPROPYLPYRAZOLO[1,5 A]PYRIMIDINE 5,7 DIAMINE; N5 (2 CHLORO 4 METHOXYPHENYL) 6 ETHYL N7,N7 DIPROPYLPYRAZOLO[1,5 A]PYRIMIDINE 5,7 DIAMINE; N5 (2 CHLORO 4 METHOXYPHENYL) 6 METHOXY N7,N7 DIPROPYLPYRAZOLO[1,5 A]PYRIMIDINE 5,7 DIAMINE; N5 (2 CHLORO 4 METHOXYPHENYL) 6 METHYL N7,N7 DIPROPYLPYRAZOLO[1,5 A]PYRIMIDINE 5,7 DIAMINE; N5 (2 CHLORO 4 METHOXYPHENYL) ISOPROPYL N7,N7 DIPROPYLPYRAZOLO[1,5 A]PYRIMIDINE 5,7 DIAMINE; N5 (2 CHLORO 4 METHOXYPHENYL) N5 (2 METHOXYMETHYL) N7,N7 DIPROPYLPYRAZOLO[1,5, A]PYRIMIDINE 5,7 DIAMINE; N5 (2 CHLORO 4 METHOXYPHENYL) N5 (2 METHYL 2 PROPENYL) N7,N7 DIPROPYLPYRAZOLO[1,5, A]PYRIMIDINE 5,7 DIAMINE; N5 (2 CHLORO 4 METHOXYPHENYL) N5 (CYCLOPROPYLMETHYL) N7,N7 DIPROPYLPYRAZOLO[1,5, A]PYRIMIDINE 5,7 DIAMINE; N5 (2 CHLORO 4 METHOXYPHENYL) N5 (METHOXYMETHYL) N7,N7 DIPROPYLPYRAZOLO[1,5, A]PYRIMIDINE 5,7 DIAMINE; N5 (2 CHLORO 4 METHOXYPHENYL) N5 ETHYL N7,N7 DIPROPYLPYRAZOLO[1,5, A]PYRIMIDINE 5,7 DIAMINE; N5 (2 CHLORO 4 METHOXYPHENYL) N5 METHYL N7,N7 DIPROPYLPYRAZOLO[1,5, A]PYRIMIDINE 5,7 DIAMINE; N5 (2 CHLORO 4 METHOXYPHENYL) N5,N7,N7 TRIPROPYLPYRAZOLO[1,5, A]PYRIMIDINE 5,7 DIAMINE; N5 (2 CHLORO 4 METHOXYPHENYL) N7 (1 ETHYLPROPYL) 6 METHYL[1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE 5,7 DIAMINE; N5 (2 CHLORO 4 METHOXYPHENYL) N7 (1 ETHYLPROPYL) 6 METHYLPYRAZOLO[1,5 A]PYRIMIDINE 5,7 DIAMINE; N5 (2 CHLORO 4 METHOXYPHENYL) N7 (1 ETHYLPROPYL) N5 METHYL[1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE 5,7 DIAMINE; N5 (2 CHLORO 4 METHOXYPHENYL) N7 (1 ETHYLPROPYL) PYRAZOLO[1,5 A]PYRIMIDINE 5,7 DIAMINE; N5 (2 CHLORO 4 METHOXYPHENYL) N7,N7 DIPROPYLPYRAZOLO[1,5 A]PYRIMIDINE 5,7 DIAMINE; N5 (2 CHLORO 4 METHOXYPHENYL) N7,N7,6 N PROPYLPYRAZOLO[1,5 A]PYRIMIDINE 5,7 DIAMINE; N5 ALLYL N5 (2 CHLORO 4 METHOXYPHENYL) N7,N7 DIPROPYLPYRAZOLO[1,5, A]PYRIMIDINE 5,7 DIAMINE; N7 (2 CHLORO 4 METHOXYPHENYL) 6 METHYL N5,N5 DIPROPYLIMIDAZO[1,2, A]PYRIMIDINE 5,7 DIAMINE; PYRAZOLO[1,5 A][1,3,5] TRIAZINE DERIVATIVE; PYRAZOLO[1,5 A]PYRIMIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TRIAZINE DERIVATIVE; TRIAZOLO[1,5 A]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; MAZE TEST; NONHUMAN; RAT;

ANIMALS; HUMANS; KINETICS; MALE; PROTEIN BINDING; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 80053242747     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.08.055     Document Type: Article

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