Heteroaryl-substituted 4-(1H-pyrazol-1-yl)-5,6-dihydro-1H-pyrrolo-[2,3-d] pyrimidine derivatives as potent and selective corticotropin-releasing factor receptor-1 antagonists

ChemMedChem

Volumn 3, Issue 2, 2008, Pages 226-229

  Sabbatini, Fabio Maria ^a   Di Fabio, Romano ^a   St Denis, Yves ^a   Capelli, Anna Maria ^a   Castiglioni, Emiliano ^a   Contini, Stefania ^a   Donati, Daniele ^a   Fazzolari, Elettra ^a   Gentile, Gabriella ^a   Micheli, Fabrizio ^a   Pavone, Francesca ^a   Rinaldi, Marilisa ^a   Pasquarello, Alessandra ^a   Zampori, Maria Grazia ^a,c   Di Felice, Pina ^a   Zarantonello, Paola ^a   Arban, Roberto ^a   Perini, Benedetta ^a   Vitulli, Giovanni ^a,b   Benedetti, Roberto ^a   Oliosi, Beatrice ^a   Worby, Angela ^a,b   more..

^a GSK   (Italy)

^b GLAXOSMITHKLINE   (United Kingdom)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Anxiety; Corticotropin releasing factor; CRF1 antagonists; Depression

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR; CRF RECEPTOR TYPE 1; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANIMAL; ANXIETY; ARTICLE; CHEMICAL MODEL; DEPRESSION; DRUG ANTAGONISM; DRUG DESIGN; METABOLISM; PATHOLOGY; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS; WISTAR RAT;

ANIMALS; ANXIETY; CORTICOTROPIN-RELEASING HORMONE; DEPRESSION; DRUG DESIGN; MODELS, CHEMICAL; PYRAZOLES; PYRIMIDINES; RATS; RATS, WISTAR; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 47649108367     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200700230     Document Type: Article

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