Preventing release in the acidic environment of the stomach via occlusion in ordered mesoporous silica enhances the absorption of poorly soluble weakly acidic drugs

Journal of Pharmaceutical Sciences

Volumn 100, Issue 11, 2011, Pages 4864-4876

  van Speybroeck, Michiel ^a   Mellaerts, Randy ^b   Thi, Thao Do ^a   Martens, Johan A ^b   Van Humbeeck, Jan ^b   Annaert, Pieter ^a   Van den Mooter, Guy ^a   Augustijns, Patrick ^a  

^a DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Absorption; Bioavailability; Glibenclamide; Indomethacin; Ordered mesoporous silica; SBA 15; Solubility; dissolution; Supersaturation

Indexed keywords

GLIBENCLAMIDE; INDOMETACIN; SILICON DIOXIDE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; IN VITRO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRECIPITATION; RAT; STOMACH JUICE; STOMACH PH; SURFACE PROPERTY; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 80053242729     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22703     Document Type: Article

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