Disabled-2 and Axin are concurrently colocalized and underexpressed in lung cancers

Human Pathology

Volumn 42, Issue 10, 2011, Pages 1491-1498

  Xu, Hong Tao ^a   Yang, Lian He ^a   Li, Qing Chang ^a   Liu, Shu Li ^a   Liu, Di ^a   Xie, Xue Mei ^a   Wang, En Hua ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Axin; Disabled 2; DNA methyltransferase 1; Lung cancer

Indexed keywords

AXIN; DISABLED 2 PROTEIN; DNA METHYLTRANSFERASE 1; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CANCER TISSUE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG SQUAMOUS CELL CARCINOMA; LYMPH NODE METASTASIS; MALE; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TUMOR DIFFERENTIATION; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CELL NUCLEUS; CYTOPLASM; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; FEMALE; HUMANS; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; REPRESSOR PROTEINS; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 80053217317     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2011.01.004     Document Type: Article

References (35)

1. Lustig B., and Behrens J. The Wnt signaling pathway and its role in tumor development J Cancer Res Clin Oncol 129 2003 199 221 (Pubitemid 36713796)
2. Prunier C., Hocevar B.A., and Howe P.H. Wnt signaling: physiology and pathology Growth Factors 22 2004 141 150 (Pubitemid 39377906)
3. Kimelman D., and Xu W. Beta-catenin destruction complex: insights and questions from a structural perspective Oncogene 25 2006 7482 7491 (Pubitemid 44885747)
4. Van Aken E., De Wever O., Correia da Rocha A.S., and Mareel M. Defective E-cadherin/catenin complexes in human cancer Virchows Arch 439 2001 725 751 (Pubitemid 33141317)
5. Xu H.T., Wang L., and Lin D. Abnormal beta-catenin and reduced Axin expression are associated with poor differentiation and progression in non-small cell lung cancer Am J Clin Pathol 125 2006 534 541
6. Chetty R., Serra S., and Salahshor S. Expression of Wnt-signaling pathway proteins in intraductal papillary mucinous neoplasms of the pancreas: a tissue microarray analysis Hum Pathol 37 2006 212 217 (Pubitemid 43099842)
7. Peng H., Zhong X.Y., Liu K.P., and Li S.M. Expression and significance of adenomatous polyposis coli, beta-catenin, E-cadherin and cyclin D1 in esophageal squamous cell carcinoma assessed by tissue microarray Ai Zheng 28 2009 38 41
8. Luo W., and Lin S.C. Axin: a master scaffold for multiple signaling pathways Neurosignals 13 2004 99 113 (Pubitemid 38456651)
9. Jones W.M., and Bejsovec A. Wingless signaling: an Axin to grind Curr Biol 13 2003 R479 481
10. Salahshor S., and Woodgett J.R. The links between Axin and carcinogenesis J Clin Pathol 58 2005 225 236 (Pubitemid 40380314)
11. Xu H.T., Wei Q., and Liu Y. Overexpression of Axin downregulates TCF-4 and inhibits the development of lung cancer Ann Surg Oncol 14 2007 3251 3259 (Pubitemid 47594295)
12. Nakajima M., Fukuchi M., Miyazaki T., Masuda N., Kato H., and Kuwano H. Reduced expression of Axin correlates with tumour progression of oesophageal squamous cell carcinoma Br J Cancer 88 2003 1734 1739 (Pubitemid 36760418)
13. Yang L.H., Xu H.T., and Han Y. Axin downregulates TCF-4 transcription via beta-catenin, but not p53, and inhibits the proliferation and invasion of lung cancer cells Mol Cancer 9 2010 25
14. Jiang Y., Prunier C., and Howe P.H. The inhibitory effects of Disabled-2 (Dab2) on Wnt signaling are mediated through Axin Oncogene 27 2008 1865 1875 (Pubitemid 351430823)
15. Hocevar B.A., Mou F., Rennolds J.L., Morris S.M., Cooper J.A., and Howe P.H. Regulation of the Wnt signaling pathway by Disabled-2 (Dab2) EMBO J 22 2003 3084 3094 (Pubitemid 36758628)
16. Jiang Y., Luo W., and Howe P.H. Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions Oncogene 28 2009 2999 3007
17. He X., Semenov M., Tamai K., and Zeng X. LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way Development 131 2004 1663 1677 (Pubitemid 38559836)
18. Zeng X., Tamai K., and Doble B. A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation Nature 438 2005 873 877 (Pubitemid 41753071)
19. Cliffe A., Hamada F., and Bienz M. A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling Curr Biol 13 2003 960 966 (Pubitemid 36632146)
20. Mok S.C., Chan W.Y., and Wong K.K. DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer Oncogene 16 1998 2381 2387 (Pubitemid 28226885)
21. Yang D.H., Smith E.R., and Cohen C. Molecular events associated with dysplastic morphologic transformation and initiation of ovarian tumorigenicity Cancer 94 2002 2380 2392 (Pubitemid 34457119)
22. Kleeff J., Huang Y., Mok S.C., Zimmermann A., Friess H., and Buchler M.W. Down-regulation of DOC-2 in colorectal cancer points to its role as a tumor suppressor in this malignancy Dis Colon Rectum 45 2002 1242 1248
23. Karam J.A., Shariat S.F., and Huang H.Y. Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder Clin Cancer Res 13 2007 4400 4406 (Pubitemid 47219706)
24. Bagadi S.A., Prasad C.P., Srivastava A., Prashad R., Gupta S.D., and Ralhan R. Frequent loss of Dab2 protein and infrequent promoter hypermethylation in breast cancer Breast Cancer Res Treat 104 2007 277 286 (Pubitemid 47231278)
25. Anupam K., Tusharkant C., Gupta S.D., and Ranju R. Loss of Disabled-2 expression is an early event in esophageal squamous tumorigenesis World J Gastroenterol 12 2006 6041 6045 (Pubitemid 44608486)
26. Tong J.H., Ng D.C., and Chau S.L. Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma BMC Cancer 10 2010 253
27. Yeh K.T., Chang J.G., and Lin T.H. Correlation between protein expression and epigenetic and mutation changes of Wnt pathway-related genes in oral cancer Int J Oncol 23 2003 1001 1007
28. Tsou J.A., Shen L.Y., and Siegmund K.D. Distinct DNA methylation profiles in malignant mesothelioma, lung adenocarcinoma, and non-tumor lung Lung Cancer 47 2005 193 204 (Pubitemid 40082162)
29. Moreno-Bueno G., Hardisson D., and Sanchez C. Abnormalities of the APC/beta-catenin pathway in endometrial cancer Oncogene 21 2002 7981 7990 (Pubitemid 35430609)
30. Pannone G., Bufo P., and Santoro A. WNT pathway in oral cancer: epigenetic inactivation of WNT-inhibitors Oncol Rep 24 2010 1035 1041
31. Hannigan A., Smith P., and Kalna G. Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter J Clin Invest 120 2010 2842 2857
32. Wiechens N., Heinle K., Englmeier L., Schohl A., and Fagotto F. Nucleo-cytoplasmic shuttling of Axin, a negative regulator of the Wnt-beta-catenin Pathway J Biol Chem 279 2004 5263 5267 (Pubitemid 38220546)
33. Tang M., Xu W., Wang Q., Xiao W., and Xu R. Potential of DNMT and its epigenetic regulation for lung cancer therapy Curr Genomics 10 2009 336 352
34. Foran E., Garrity-Park M.M., and Mureau C. Upregulation of DNA methyltransferase-mediated gene silencing, anchorage-independent growth, and migration of colon cancer cells by interleukin-6 Mol Cancer Res 8 2010 471 481
35. Kastl L., Brown I., and Schofield A.C. Altered DNA methylation is associated with docetaxel resistance in human breast cancer cells Int J Oncol 36 2010 1235 1241