Discovery of gemfibrozil analogues that activate PPARα and enhance the expression of gene CPT1A involved in fatty acids catabolism

European Journal of Medicinal Chemistry

Volumn 46, Issue 10, 2011, Pages 5218-5224

  De Filippis, Barbara ^a   Giancristofaro, Antonella ^b   Ammazzalorso, Alessandra ^a   D'Angelo, Alessandra ^a   Fantacuzzi, Marialuigia ^a   Giampietro, Letizia ^a   MacCallini, Cristina ^a   Petruzzelli, Michele ^b   Amoroso, Rosa ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b Consorzio Mario Negri Sud ^*  (Italy)

Author keywords

Analogues of gemfibrozil; Fibrates; Nuclear receptors modulators; PPAR ; Stilbene

Indexed keywords

2 [4 [2 [3 CYCLOHEXYL 1 (4 CYCLOHEXYLBUTYL)UREIDO]ETHYL]PHENYLTHIO] 2 METHYLPROPIONIC ACID; 2,2 DIMETHYL 5 (4 PHENOXYPHENOXY)PENTANOIC ACID; 2,2 DIMETHYL 5 [4 (2 PHENYLVINYL)PHENOXY]PENTANOIC ACID; 2,2 DIMETHYL 5 [4 (PHENYLDIAZENYL)PHENOXY]PENTANOIC ACID; 5 (2 METHOXY 4 ALLYLPHENOXY) 2,2 DIMETHYLPENTANOIC ACID; 5 (4 ALLYL 2 METHOXYPHENOXY)PENTANOIC ACID; 5 (4 BENZOYLPHENOXY) 2,2 DIMETHYLPENTANOIC ACID; 5 (4 BENZOYLPHENOXY)PENTANOIC ACID; 5 [4 ((ANILINOCARBONYL)AMINO)PHENOXY]PENTANOIC ACID; 5 [4 (2 PHENYLVINYL)PHENOXY]PENTANOIC ACID; ALPHA ASARONE; CARNITINE PALMITOYL ACYL COENZYME A TRANSFERASE 1; CHALCONE; COENZYME A TRANSFERASE; FATTY ACID; GEMFIBROZIL; METHYL GROUP; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PHENYL GROUP; STILBENE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DEMETHYLATION; DRUG CONJUGATION; DRUG SCREENING; DRUG SYNTHESIS; FATTY ACID METABOLISM; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; LIPOLYSIS;

CARNITINE O-PALMITOYLTRANSFERASE; FATTY ACIDS; GEMFIBROZIL; HEP G2 CELLS; HUMANS; PPAR ALPHA; UP-REGULATION;

EID: 80053213260     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.08.022     Document Type: Article

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