Pan-PPAR agonists based on the resveratrol scaffold: Biological evaluation and docking studies

ChemMedChem

Volumn 5, Issue 12, 2010, Pages 1977-1982

  Li, Wei ^a,b   He, Xinhua ^a   Shi, Weiguo ^a   Jia, Haoyan ^a   Zhong, Bohua ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b INSTITUTE OF MICROBIOLOGY   (China)

Author keywords

Metabolic diseases; Molecular modeling; Pan PPAR agonists; Receptors; Resveratrol

Indexed keywords

3,4' DIMETHOXYRESVERATROL; BROMOHEXADECANOIC ACID; FENOFIBRATE; FENOFIBRIC ACID; GW 409544; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; RESVERATROL; ROSIGLITAZONE; STILBENE; UNCLASSIFIED DRUG;

ALLOXAN DIABETES MELLITUS; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CARBOHYDRATE METABOLISM; DISEASE PREDISPOSITION; DRUG BINDING; DRUG EFFECT; ENZYME ACTIVATION; FATTY ACID OXIDATION; GLUCOSE HOMEOSTASIS; HUMAN; INSULIN SENSITIVITY; LIPID STORAGE; METABOLIC SYNDROME X; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; DIABETES MELLITUS, EXPERIMENTAL; DIETARY FATS; DISEASE MODELS, ANIMAL; HUMANS; MICE; PENTANOIC ACIDS; PPAR ALPHA; PPAR DELTA; PPAR GAMMA; PROTEIN STRUCTURE, TERTIARY; STILBENES;

EID: 78651501250     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000360     Document Type: Article

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