Tobacco-specific carcinogen nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl) -1-butanone induces AKT activation in head and neck epithelia

International Journal of Oncology

Volumn 39, Issue 5, 2011, Pages 1193-1198

  Weber, Stephen M ^a   Bornstein, Sophia ^a   Li, Yuexin ^a   Malkoski, Stephen P ^b   Wang, Donna ^c   Rustgi, Anil K ^d   Kulesz Martin, Molly F ^a   Wang, Xiao Jing ^c   Lu, Shi Long ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

AKT; Head and neck epithelia; Head and neck squamous cell carcinoma; NNK; Tobacco

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; ETOPOSIDE; GLYCOGEN SYNTHASE KINASE 3BETA; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN BAD; PROTEIN KINASE B; PROTEIN MDM2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; LARYNX CARCINOMA; MOUSE; MOUTH CARCINOMA; NONHUMAN; PHARYNX CARCINOMA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOKING; SQUAMOUS CELL CARCINOMA; TOBACCO; TONGUE CARCINOMA;

ANIMALS; APOPTOSIS; CARCINOGENS; CARCINOMA, SQUAMOUS CELL; CELL LINE; CELL PROLIFERATION; ENZYME ACTIVATION; HEAD AND NECK NEOPLASMS; HUMANS; MICE; MICE, INBRED C57BL; NITROSAMINES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TOBACCO;

EID: 80053213076     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.1149     Document Type: Article

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