Alteration in body composition in the portacaval anastamosis rat is mediated by increased expression of myostatin

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 301, Issue 4, 2011, Pages

  Dasarathy, Srinivasan ^a,b   Muc, Sean ^b   Runkana, Ashok ^b   Mullen, Kevin Daniel ^a   Kaminsky Russ, Kristine ^a   McCullough, Arthur Joseph ^a,b  

^a METROHEALTH MEDICAL CENTER   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

AMP kinase; Carcass analysis; Fat mass; Fatty acid oxidation; Lipogenesis; Total body electrical conductivity

Indexed keywords

ADENYLATE KINASE; MYOSTATIN; TRIACYLGLYCEROL;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; CARCASS; CONTROLLED STUDY; ELECTRIC CONDUCTIVITY; EPIDIDYMIS FAT; GENE EXPRESSION; LIVER CIRRHOSIS; MALE; NONHUMAN; PORTOSYSTEMIC ANASTOMOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SHAM PROCEDURE; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE, WHITE; ANIMALS; BODY COMPOSITION; FATTY ACIDS; FOLLISTATIN; MALE; MYOSTATIN; OXIDATION-REDUCTION; PORTACAVAL SHUNT, SURGICAL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 80053192995     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00161.2011     Document Type: Article

References (43)

1. Alberino F, Gatta A, Amodio P, Merkel C, Di PL, Boffo G, Caregaro L. Nutrition and survival in patients with liver cirrhosis. Nutrition 17: 445-450, 2001.
2. Artaza JN, Bhasin S, Magee TR, Reisz-Porszasz S, Shen R, Groome NP, Meerasahib MF, Gonzalez-Cadavid NF. Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells. Endocrinology 146: 3547-3557, 2005.
3. Assal JP, Levrat R, Cahn T, Renold AE. Metabolic consequences of portacaval shunting in the rat. Effects on weight, food intake, intestinal absorption and hepatic morphology. Z Gesamte Exp Med 154: 87-100, 1971.
4. Balagopal P, George D, Yarandi H, Funanage V, Bayne E. Reversal of obesity-related hypoadiponectinemia by lifestyle intervention: a controlled, randomized study in obese adolescents. J Clin Endocrinol Metab 90: 6192-6197, 2005.
5. Battistini N, Virgili F, Bedogni G, Gambella GR, Bini A. In vivo total body water assessment by total body electrical conductivity in rats suffering perturbations of water compartment equilibrium. Br J Nutr 70: 433-438, 1993.
6. Benabdallah BF, Bouchentouf M, Rousseau J, Bigey P, Michaud A, Chapdelaine P, Scherman D, Tremblay JP. Inhibiting myostatin with follistatin improves the success of myoblast transplantation in dystrophic mice. Cell Transplant 17: 337-350, 2008.
7. Chen Y, Ye J, Cao L, Zhang Y, Xia W, Zhu D. Myostatin regulates glucose metabolism via the AMP-activated protein kinase pathway in skeletal muscle cells. Int J Biochem Cell Biol 42: 2072-2081, 2010.
8. Clark RG, Tarttelin MF. Some effects of ovariectomy and estrogen replacement on body composition in the rat. Physiol Behav 28: 963-969, 1982.
9. Coughlin CC, Finck BN, Eagon JC, Halpin VJ, Magkos F, Mohammed BS, Klein S. Effect of marked weight loss on adiponectin gene expression and plasma concentrations. Obesity (Silver Spring) 15: 640-645, 2007.
10. Coy DL, Srivastava A, Gottstein J, Butterworth RF, Blei AT. Postoperative course after portacaval anastomosis in rats is determined by the portacaval pressure gradient. Am J Physiol Gastrointest Liver Physiol 261: G1072-G1078, 1991.
11. Dasarathy S, Dodig M, Muc SM, Kalhan SC, McCullough AJ. Skeletal muscle atrophy is associated with an increased expression of myostatin and impaired satellite cell function in the portacaval anastamosis rat. Am J Physiol Gastrointest Liver Physiol 287: G1124-G1130, 2004.
12. Dasarathy S, McCullough AJ, Muc S, Schneyer A, Bennett CD, Dodig M, Kalhan SC. Sarcopenia associated with portosystemic shunting is reversed by follistatin. J Hepatol 54: 915-921, 2010.
13. Dasarathy S, Muc S, Hisamuddin K, Edmison JM, Dodig M, Mc- Cullough AJ, Kalhan SC. Altered expression of genes regulating skeletal muscle mass in the portacaval anastomosis rat. Am J Physiol Gastrointest Liver Physiol 292: G1105-G1113, 2007.
14. Dasarathy S, Mullen KD, Conjeevaram HS, Kaminsky-Russ K, Wills LA, McCullough AJ. Preservation of portal pressure improves growth and metabolic profile in the male portacaval-shunted rat. Dig Dis Sci 47: 1936-1942, 2002.
15. Dasarathy S, Mullen KD, Dodig M, Donofrio B, McCullough AJ. Inhibition of aromatase improves nutritional status following portacaval anastomosis in male rats. J Hepatol 45: 214-220, 2006.
16. Feldman BJ, Streeper RS, Farese RV Jr, Yamamoto KR. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc Natl Acad Sci U S A 103: 15675-15680, 2006.
17. Figueiredo FA, Perez RM, Freitas MM, Kondo M. Comparison of three methods of nutritional assessment in liver cirrhosis: subjective global assessment, traditional nutritional parameters, and body composition analysis. J Gastroenterol 41: 476-482, 2006.
18. Fisher B, Lee S, Fedor EJ, Levine M. Intestinal absorption and nitrogen balance following portacaval shunt. Ann Surg 167: 41-46, 1968.
19. Fujita S, Dreyer HC, Drummond MJ, Glynn EL, Cadenas JG, Yoshizawa F, Volpi E, Rasmussen BB. Nutrient signalling in the regulation of human muscle protein synthesis. J Physiol 582: 813-823, 2007.
20. Guo T, Jou W, Chanturiya T, Portas J, Gavrilova O, McPherron AC. Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity. PLos One 4: e4937, 2009.
21. Hamrick MW, Pennington C, Webb CN, Isales CM. Resistance to body fat gain in "double-muscled" mice fed a high-fat diet. Int J Obes (Lond) 30: 868-870, 2006.
22. Kim HS, Liang L, Dean RG, Hausman DB, Hartzell DL, Baile CA. Inhibition of preadipocyte differentiation by myostatin treatment in 3T3-L1 cultures. Biochem Biophys Res Commun 281: 902-906, 2001.
23. Lauterburg B, Bircher J. Defective renal handling of water in the rat with a portacaval shunt. Eur J Clin Invest 6: 439-444, 1976.
24. Lee SJ, Lee YS, Zimmers TA, Soleimani A, Matzuk MM, Tsuchida K, Cohn RD, Barton ER. Regulation of muscle mass by follistatin and activins. Mol Endocrinol 24: 1998-2008, 2010.
25. Lin J, Arnold HB, la-Fera MA, Azain MJ, Hartzell DL, Baile CA. Myostatin knockout in mice increases myogenesis and decreases adipogenesis. Biochem Biophys Res Commun 291: 701-706, 2002.
26. Machida S, Booth FW. Insulin-like growth factor 1 and muscle growth: implication for satellite cell proliferation. Proc Nutr Soc 63: 337-340, 2004.
27. Muller MJ, Bottcher J, Selberg O, Weselmann S, Boker KH, Schwarze M, von zur MA, Manns MP. Hypermetabolism in clinically stable patients with liver cirrhosis. Am J Clin Nutr 69: 1194-1201, 1999.
28. Nakatani M, Kokubo M, Ohsawa Y, Sunada Y, Tsuchida K. Follistatin- derived peptide expression in muscle decreases adipose tissue mass and prevents hepatic steatosis. Am J Physiol Endocrinol Metab 300: E543-E553, 2011.
29. Nishida M, Funahashi T, Shimomura I. Pathophysiological significance of adiponectin. Med Mol Morphol 40: 55-67, 2007.
30. Pantzar N, Bergqvist PB, Bugge M, Olaison G, Lundin S, Jeppsson B, Westrom B, Bengtsson F. Small intestinal absorption of polyethylene glycol 400 to 1,000 in the portacaval shunted rat. Hepatology 21: 1167-1173, 1995.
31. Pector JC, Winand J, Verbeustel S, Hebbelinck M, Christophe J. Effects of portacaval diversion on lipid metabolism in rat adipose tissue. Am J Physiol Endocrinol Metab Gastrointest Physiol 234: E759-E783, 1978.
32. Penicaud L, Cousin B, Leloup C, Lorsignol A, Casteilla L. The autonomic nervous system, adipose tissue plasticity, and energy balance. Nutrition 16: 903-908, 2000.
33. Pitts GC, Ushakov AS, Pace N, Smith AH, Rahlmann DF, Smirnova TA. Effects of weightlessness on body composition in the rat. Am J Physiol Regul Integr Comp Physiol 244: R332-R337, 1983.
34. Plauth M, Schutz ET. Cachexia in liver cirrhosis. Int J Cardiol 85: 83-87, 2002.
35. Rebbapragada A, Benchabane H, Wrana JL, Celeste AJ, Attisano L. Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Mol Cell Biol 23: 7230-7242, 2003.
36. Reisz-Porszasz S, Bhasin S, Artaza JN, Shen R, Sinha-Hikim I, Hogue A, Fielder TJ, Gonzalez-Cadavid NF. Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin. Am J Physiol Endocrinol Metab 285: E876-E888, 2003.
37. Robin JP, Heitz A, Le MY, Lignon J. Physical limitations of the TOBEC method: accuracy and long-term stability. Physiol Behav 75: 105-118, 2002.
38. Rodgers BD, Garikipati DK. Clinical, agricultural, and evolutionary biology of myostatin: a comparative review. Endocr Rev 29: 513-534, 2008.
39. Squibb RL, Aguirre A, Braham JE, Scrimshaw NS, Brigeforth E. Effect of age, sex and feeding regimen on fat digestibility in individual rats as determined by a rapid extraction procedure. J Nutr 64: 625-634, 1958.
40. Swarbrick MM, Havel PJ. Physiological, pharmacological, and nutritional regulation of circulating adiponectin concentrations in humans. Metab Syndr Relat Disord 6: 87-102, 2008.
41. Thornton-Jones ZD, Kennett GA, Benwell KR, Revell DF, Misra A, Sellwood DM, Vickers SP, Clifton PG. The cannabinoid CB1 receptor inverse agonist, rimonabant, modifies body weight and adiponectin function in diet-induced obese rats as a consequence of reduced food intake. Pharmacol Biochem Behav 84: 353-359, 2006.
42. Wicklmayr M, Rett K, Schwiegelshohn B, Wolfram G, Hailer S, Dietze G. Inhibition of muscular amino acid release by lipid infusion in man. Eur J Clin Invest 17: 301-305, 1987.
43. Zimmers TA, Davies MV, Koniaris LG, Haynes P, Esquela AF, Tomkinson KN, McPherron AC, Wolfman NM, Lee SJ. Induction of cachexia in mice by systemically administered myostatin. Science 296: 1486-1488, 2002.