Activation by 2-arachidonoylglycerol of platelet p38MAPK/cPLA 2 pathway

Journal of Cellular Biochemistry

Volumn 112, Issue 10, 2011, Pages 2794-2802

  Signorello, Maria Grazia ^a   Giacobbe, Enrica ^a   Leoncini, Giuliana ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

2 arachidonoylglycerol; arachidonic acid; human platelets; p38MAPK; phospholipase A 2

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; 5,8,11,14 ICOSATETRAYNOIC ACID; APYRASE; ARACHIDONIC ACID; ARGINYLGLYCYLASPARTYLSERINE; CALCIUM; CYTOSOLIC PHOSPHOLIPASE A2; INDOMETACIN; MITOGEN ACTIVATED PROTEIN KINASE P38; OXYGEN RADICAL; REACTIVE OXYGEN METABOLITE; RIMONABANT; THROMBOXANE B2;

ARTICLE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; NORMAL HUMAN; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

APYRASE; ARACHIDONIC ACID; ARACHIDONIC ACIDS; BLOOD PLATELETS; GLYCERIDES; HUMANS; IMIDAZOLES; INDOMETHACIN; OLIGOPEPTIDES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOLIPASES A2, CYTOSOLIC; PHOSPHORYLATION; PIPERIDINES; PYRAZOLES; PYRIDINES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 80053182170     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.23194     Document Type: Article

References (35)

1. Baldassarri S, Bertoni A, Bagarotti A, Sarasso C, Zanfa M, Catani MV, Avigliano L, Maccarrone M, Torti M, Sinigaglia F,. 2008. The endocannabinoid 2-arachidonoylglycerol activates human platelets through non-CB1/CB2 receptors. J Thromb Haemost 6: 1772-1779.
2. Born GVR,. 1962. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 194: 927-929.
3. Borsch-Haubold AG, Kramer RM, Watson SP,. 1995. Cytosolic phospholipase A2 is phosphorylated in collagen- and thrombin-stimulated human platelets independent of protein kinase C and mitogen-activated protein kinase. J Biol Chem 270: 25885-25892.
4. 2 by 38-kDa mitogen-activated protein kinase in collagen-stimulated human platelets. Eur J Biochem 245: 751-759. (Pubitemid 27223910)
5. 2 in agonist-stimulated human platelets and HeLa cells. J Biol Chem 273: 4449-4458. (Pubitemid 28103183)
6. Borsch-Haubold AG, Pasquet S, Watson SP,. 1998. Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. SB 203580 also inhibits thromboxane synthase. J Biol Chem 273: 28766-28772. (Pubitemid 28507565)
7. Brandt R, Keston AS,. 1965. Synthesis of diacetyldichlorofluorescin: A stable reagent for fluorimetric analysis. Anal Biochem 11: 6-9.
8. Canobbio I, Reineri S, Sinigaglia F, Balduini C, Torti M,. 2004. A role for p38 MAP kinase in platelet activation by von Willebrand factor. Thromb Haemost 91: 102-110. (Pubitemid 38111227)
9. Catani MV, Fezza F, Baldassarri S, Gasperi V, Bertoni A, Pasquariello N, Finazzi-Agrò A, Sinigaglia F, Avigliano L, Maccarrone M,. 2009. Expression of the endocannabinoid system in the bi-potential HEL cell line: Commitment to the megakaryoblastic lineage by 2-arachidonoylglycerol. J Mol Med 87: 65-74.
10. Catani MV, Gasperi V, Catanzaro G, Baldassarri S, Bertoni A, Sinigaglia F, Avigliano L, Maccarrone M,. 2010. Human platelets express authentic CB(1) and CB(2) receptors. Curr Neurovasc Res 7: 311-318.
11. Clark JD, Lin LL, Kriz RW, Ramesha CS, Sultzman LA, Lin AY, Milona N, Knopf JL,. 1991. A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP. Cell 65: 1043-1051. (Pubitemid 121001692)
12. Di Marzo V, Bisogno T, Sugiura T, Melck D, De Petrocellis L,. 1998. The novel endogenous cannabinoid 2-arachidonoylglycerol is inactivated by neuronal- and basophil-like cells: Connections with anandamide. Biochem J 331: 15-19. (Pubitemid 28163951)
13. Di Marzo V, Bisogno T, De Petrocellis L, Melck D, Orlando P, Wagner JA, Kunos G,. 1999. Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages. Eur J Biochem 264: 258-267. (Pubitemid 29385890)
14. Hackeng CM, Relou IA, Pladet MW, Gorter G, van Rijn HJ, Akkerman JW,. 1999. Early platelet activation by low density lipoprotein via p38 MAP kinase. Thromb Haemost 82: 1749-1756.
15. Kobayashi Y, Arai S, Waku K, Sugiura T,. 2001. Activation by 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, of p42/44 mitogen-activated protein kinase in HL-60 cells. J Biochem 129: 665-669. (Pubitemid 32499776)
16. Kramer RM, Roberts EF, Strifler BA, Johnstone EM,. 1995. Thrombin induces activation of p38 MAP kinase in human platelets. J Biol Chem 270: 27395-27398.
17. 2. J Biol Chem 271: 27723-27729. (Pubitemid 26367343)
18. 2 (cPLA2). FEBS Lett 410: 49-53. (Pubitemid 27283382)
19. Keown OP, Winterburn TJ, Wainwright CL, Macrury SM, Neilson I, Barrett F, Leslie SJ, Megson IL,. 2010. 2-arachidonyl glycerol activates platelets via conversion to arachidonic acid and not by direct activation of cannabinoid receptors. Br J Clin Pharmacol 70: 180-188.
20. 2 is coupled to hormonally regulated release of arachidonic acid. Proc Natl Acad Sci USA 89: 6147-6151.
21. Maccarrone M, Bari M, Menichelli A, Giuliani E, Del Principe D, Finazzi-Agrò A,. 2001. Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor. Eur J Biochem 268: 819-825. (Pubitemid 32862642)
22. Mach F, Montecucco F, Steffens S,. 2009. Effect of blockage of the endocannabinoid system by CB(1) antagonism on cardiovascular risk. Pharmacol Rep 61: 13-21.
23. Maresca M, Colao C, Leoncini G,. 1992. Generation of hydrogen peroxide in resting and activated platelets. Cell Biochem Funct 10: 79-85.
24. Nalefski EA, Sultzman LA, Martin DM, Kriz RW, Towler PS, Knopf JL, Clark JD,. 1994. Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent lipid-binding domain and a Ca(2+)-independent catalytic domain. J Biol Chem 269: 18239-18249.
25. 2. J Biol Chem 27: 1596-1604. (Pubitemid 28133685)
26. Petrosino S, Ligresti A, Di Marzo V,. 2009. Endocannabinoid chemical biology: A tool for the development of novel therapies. Curr Opin Chem Biol 13: 309-320.
27. Randall MD,. 2007. Endocannabinoids and the haematological system. Br J Pharmacol 152: 671-675. (Pubitemid 350034975)
28. Saklatvala J, Rawlinson L, Waller RJ, Sarsfield S, Lee JC, Morton LF, Barnes MJ, Farndale RW,. 1996. Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue. J Biol Chem 271: 6586-6589. (Pubitemid 26104083)
29. Salzet M, Breton C, Bisogno T, Di Marzo V,. 2000. Comparative biology of the endocannabinoid system possible role in the immune response. Eur J Biochem 267: 4917-4927. (Pubitemid 30641288)
30. Schäfer A, Pfrang J, Neumüller J, Fiedler S, Ertl G, Bauersachs J,. 2008. The cannabinoid receptor-1 antagonist rimonabant inhibits platelet activation and reduces pro-inflammatory chemokines and leukocytes in Zucker rats. Br J Pharmacol 154: 1047-1054. (Pubitemid 351915060)
31. 2 to the nuclear envelope and endoplasmic reticulum. J Biol Chem 270: 30749-30754. (Pubitemid 26005142)
32. Six DA, Dennis EA,. 2003. Essential Ca(2+)-independent role of the group IVA cytosolic phospholipase A(2) C2 domain for interfacial activity. J Biol Chem 278: 23842-23850. (Pubitemid 36830210)
33. Sugiura T, Kodaka T, Nakane S, Kishimoto S, Kondo S, Waku K,. 1998. Detection of an endogenous cannabimimetic molecule, 2-arachidonoylglycerol, and cannabinoid CB1 receptor mRNA in human vascular cells: Is 2-arachidonoylglycerol a possible vasomodulator? Biochem Biophys Res Commun 243: 838-843. (Pubitemid 28414169)
34. Sugiura T, Waku K,. 2002. Cannabinoid receptors and their endogenous ligands. J Biochem 132: 7-12. (Pubitemid 34832264)
35. Sugiura T, Kishimoto S, Oka S, Gokoh M,. 2006. Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. Prog Lipid Res 45: 405-446.