Effect of +-thalassaemia on episodes of fever due to malaria and other causes: A community-based cohort study in Tanzania

Malaria Journal

Volumn 10, Issue , 2011, Pages

  Veenemans, Jacobien ^a,e   Jansen, Esther J S ^a   Baidjoe, Amrish Y ^a   Mbugi, Erasto V ^b   Demir, Aye Y ^c   Kraaijenhagen, Rob J ^c   Savelkoul, Huub F J ^a   Verhoef, Hans ^a,d  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^c MEANDER MEDICAL CENTER   (Netherlands)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^e AMPHIA HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; C REACTIVE PROTEIN; HEMOGLOBIN;

AGE; ALPHA THALASSEMIA; BODY HEIGHT; DISEASE ASSOCIATION; DISEASE SEVERITY; FEVER; FOLLOW UP; GENOTYPE; HEMOGLOBIN BLOOD LEVEL; HETEROZYGOTE; HOMOZYGOTE; HUMAN; INCIDENCE; OUTCOME ASSESSMENT; PLASMODIUM FALCIPARUM; PLASMODIUM MALARIAE INFECTION; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; REVIEW; SCORING SYSTEM; TANZANIA; ARTICLE; COHORT ANALYSIS; FEMALE; INFANT; MALARIA; MALE; PATHOLOGY; PRESCHOOL CHILD; PYREXIA IDIOPATHICA; STATISTICAL MODEL;

AGE FACTORS; ALPHA-THALASSEMIA; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; FEVER OF UNKNOWN ORIGIN; HUMANS; INCIDENCE; INFANT; MALARIA; MALE; MODELS, STATISTICAL; PROSPECTIVE STUDIES; TANZANIA;

EID: 80053176046     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-10-280     Document Type: Review

References (33)

1. +-thalassemia protects against anemia associated with asymptomatic malaria: evidence from community-based surveys in Kenya and Tanzania. Veenemans J, Andang'o PEA, Mbugi EV, Kraaijenhagen RJ, Mwaniki DL, Mockenhaupt FP, Roewer S, Olomi RM, Shao JF, Van der Meer JWM, Savelkoul HFJ, Verhoef H, J Infect Dis 2008 198 401 408 10.1086/589884 18582194
2. Alpha+-thalassemia protects children against disease caused by other infections as well as malaria. Allen SJ, O'Donnell A, Alexander ND, Alpers MP, Peto TEA, Clegg JB, Weatherall DJ, Proc Natl Acad Sci USA 1997 94 14736 14741 10.1073/pnas.94.26.14736 9405682 (Pubitemid 28041443)
3. Alpha+-thalassemia protects African children from severe malaria. Mockenhaupt FP, Ehrhardt S, Gellert S, Otchwemah RN, Dietz E, Anemana SD, Bienzle U, Blood 2004 104 2003 2006 10.1182/blood-2003-11-4090 15198952 (Pubitemid 39297850)
4. Hemoglobin variants and disease manifestations in severe falciparum malaria. May J, Evans JA, Timmann C, Ehmen C, Busch W, Thye T, Agbenyega T, Horstmann RD, JAMA 2007 297 2220 2226 10.1001/jama.297.20.2220 17519411 (Pubitemid 47010879)
5. Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya. Williams TN, Wambua S, Uyoga S, Macharia A, Mwacharo JK, Newton CRJC, Maitland K, Blood 2005 106 368 371 10.1182/blood-2005-01-0313 15769889 (Pubitemid 40967215)
6. The effect of +-thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya. Wambua S, Mwangi TW, Kortok M, Uyoga SM, Macharia AW, Mwacharo JK, Weatherall DJ, Snow RW, Marsh K, Williams TN, PLoS Med 2006 3 158 10.1371/journal.pmed.0030158 16605300 (Pubitemid 43807033)
7. High incidence of malaria in alpha-thalassaemic children. Williams TN, Maitland K, Bennett S, Ganczakowski M, Peto TEA, Newbold CI, Bowden DK, Weatherall DJ, Clegg JB, Nature 1996 383 522 525 10.1038/383522a0 8849722 (Pubitemid 26346177)
8. +-thalassaemia on morbidity from malaria and immune responses to defined Plasmodium falciparum antigens in Gambian children. Allen SJ, Rowe P, Allsopp CEM, Riley EM, Jakobsen PH, Hill AVS, Greenwood BM, Trans R Soc Trop Med Hyg 1993 87 282 285 10.1016/0035-9203(93)90129-E 8236392
9. Negative epistasis between the malaria-protective effects of +-thalassemia and the sickle cell trait. Williams TN, Mwangi TW, Wambua S, Peto TEA, Weatherall DJ, Gupta S, Recker M, Penman BS, Uyoga S, Macharia A, Mwacharo JK, Snow RW, Marsh K, Nat Genet 2005 37 1253 1257 10.1038/ng1660 16227994 (Pubitemid 41568709)
10. Reduced risk of uncomplicated malaria episodes in children with alpha-thalassemia in Northeastern Tanzania. Enevold A, Lusingu JP, Mmbando B, Alifrangis M, Lemnge MM, Bygbjerg IC, Theander TG, Vestergaard LS, Am J Trop Med Hyg 2008 78 714 720 18458302 (Pubitemid 351845125)
11. Malaria and anaemia at different altitudes in the Muheza district of Tanzania: childhood morbidity in relation to level of exposure to infection. Ellman R, Maxwell C, Finch R, Shayo D, Ann Trop Med Parasitol 1998 92 741 753 10.1080/00034989858989 9924532 (Pubitemid 29355488)
12. Immunocapture diagnostic assays for malaria using Plasmodium lactate dehydrogenase (pLDH). Piper R, Lebras J, Wentworth L, Hunt-Cooke A, Houzé S, Chiodini P, Makler M, Am J Trop Med Hyg 1999 60 109 118 9988333 (Pubitemid 29066014)
13. Rapid detection of alpha-thalassaemia deletions and alpha-globin gene triplication by multiplex polymerase chain reactions. Liu YT, Old JM, Miles K, Fisher CA, Weatherall DJ, Clegg JB, Br J Haematol 2000 108 295 299 10.1046/j.1365-2141.2000.01870.x 10691858 (Pubitemid 30143644)
14. Human red blood cell polymorphisms and malaria. Williams TN, Curr Opin Microbiol 2006 9 388 94 10.1016/j.mib.2006.06.009 16815736 (Pubitemid 44108720)
15. Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2. Dondorp AM, Desakorn V, Pongtavornpinyo W, Sahassananda D, Silamut K, Chotivanich K, Newton PN, Pitisuttithum P, Smithyman AM, White NJ, Day NPJ, PLoS Med 2005 2 788 795
16. Statistics with confidence: confidence intervals and statistical guidelines. Altman DG, Machin D, Bryant TN, Gardner MJ, eds, London, UK: BMJ Books 2000
17. http://www.cdc.gov/epiinfo Accessed 30 August 2011
18. Do high levels of c-reactive protein in tanzanian children indicate malaria morbidity? Hurt N, Smith T, Teuscher T, Tanner M, Clin Diagn Lab Immunol 1994 1 437 444 8556482 (Pubitemid 2111074)
19. Evaluation of C-reactive protein and haptoglobin as malaria episode markers in an area of high transmission in Africa. Hurt N, Smith T, Tanner M, Mwankusye S, Bordmann G, Weiss NA, Teuscher T, Trans R Soc Trop Med Hyg 1994 88 182 186 10.1016/0035-9203(94)90287-9 8036666 (Pubitemid 24139681)
20. What is clinical malaria? Finding case definitions for field research in highly endemic areas. Schellenberg JRM, Smith T, Alonso PL, Hayes RJ, Parasitol Today 1994 10 439 442 10.1016/0169-4758(94)90179-1 15275531 (Pubitemid 24321978)
21. Attributable fraction estimates and case definitions for malaria in endemic areas. Smith T, Schellenberg JA, Hayes R, Stat Med 1994 13 2345 2358 10.1002/sim.4780132206 7855468 (Pubitemid 24354857)
22. Malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria. O'Meara WP, Hall BF, McKenzie FE, Malaria J 2007 6 36 10.1186/1475-2875-6-36 (Pubitemid 46595080)
23. Measures of clinical malaria in field trials of interventions against Plasmodium falciparum. Smith TA, Malar J 2007 6 53 10.1186/1475-2875-6-53 17475000 (Pubitemid 46786623)
24. When is "malaria" malaria? The different burdens of malaria infection, malaria disease, and malaria-like illnesses. Koram KA, Molyneux ME, Am J Trop Med Hyg 2007 77 Suppl 6 1 5 18165468
25. What does a single determination of malaria parasite density mean? A longitudinal survey in Mali. Delley V, Bouvier P, Breslow N, Doumbo O, Sagara I, Diakite M, Mauris A, Dolo A, Rougemont A, Trop Med Int Health 2000 5 404 412 10.1046/j.1365-3156.2000.00566.x 10929139 (Pubitemid 30469974)
26. The increased susceptibility of young red cells to invasion by the malarial parasite Plasmodium falciparum. Pasvol G, Weatherall DJ, Wilson RJ, Br J Haematol 1980 45 285 95 10.1111/j.1365-2141.1980.tb07148.x 7002199 (Pubitemid 10120179)
27. The interaction of malaria parasites with red blood cells. Pasvol G, Wilson RJ, Br Med Bull 1982 38 133 40 7052193 (Pubitemid 12008182)
28. The thalassaemia syndromes. Weatherall DJ, Clegg JB, Oxford, UK: Blackwell Science 4 2001
29. +-thalassemia. Krugner F, Zaccariotto TR, Rosim ET, Costa FF, Grotto HZ, Sonati MF, Am J Hematol 2006 81 68 70 10.1002/ajh.20487 16369954 (Pubitemid 43077217)
30. Protection by alpha-thalassaemia against Plasmodium falciparum malaria: modified surface antigen expression rather than impaired growth or cytoadherence. Luzzi GA, Merry AH, Newbold CI, Marsh K, Pasvol G, Immunol Lett 1991 30 233 240 10.1016/0165-2478(91)90031-5 1757109
31. Red cell deformability, splenic function and anemia in thalassemia. Dondorp AM, Chotivanich KT, Fucharoen S, Silamut K, Vreeken J, Kager PA, White NJ, Brit J Haem 1999 105 505 508 10.1111/j.1365-2141.1999.01367.x (Pubitemid 29232178)
32. Relation between severe malaria morbidity in children and level of Plasmodium falciparum transmission in Africa. Snow RW, Omumbo JA, Lowe B, Molyneux CS, Obiero J-O, Palmer A, Weber MW, Pinder M, Nahlen B, Obonyo C, Newbold C, Gupta S, Marsh K, Lancet 1997 349 1650 1654 10.1016/S0140-6736(97) 02038-2 9186382 (Pubitemid 27234806)
33. +- thalassaemia contributes to protection against severe malarial anaemia. Fowkes FJI, Allen SJ, Allen A, Alpers MP, Weatherall DJ, Day KP, PLoS Med 2008 5 494 501