α+-thalassemia protects African children from severe malaria

Blood

Volumn 104, Issue 7, 2004, Pages 2003-2006

  Mockenhaupt, Frank P ^a   Ehrhardt, Stephan ^b   Gellert, Sabine ^b   Otchwemah, Rowland N ^b   Dietz, Ekkehart ^b   Anemana, Sylvester D ^b   Bienzle, Ulrich ^b  

^a Institute of Tropical Medicine   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AFRICA; ALPHA THALASSEMIA; ARTICLE; CASE CONTROL STUDY; CHILD; CONTROLLED STUDY; ENDEMIC DISEASE; GHANA; HUMAN; MAJOR CLINICAL STUDY; MALARIA; PARASITEMIA; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL;

EID: 4644337767     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-11-4090     Document Type: Article

References (21)

1. WHO. Severe falciparum malaria. Trans R Soc Trap Med Hyg. 2000;94(suppl 1)1-90.
2. Aidoo M, Terlouw DJ, Kolczak MS. et al. Protective effects of the sickle cell gene against malaria morbidity and mortality. Lancet. 2002;359:1311-1312.
3. Lell B, May J, Schmidt-Ott RJ, et al. The role of red blood cell polymorphisms in resistance and susceptibility to malaria. Clin Infect Dis. 1999;28:794-799.
4. Guggenmoos-Holzmann I, Bienzle U, Luzzatto L. Plasmodium falciparum malaria and human red cells, II: red cell genetic traits and resistance against malaria. Int J Epidemiol. 1981;10:16-22.
5. Haldane JBS. The rate of mutation of human genes. Hereditas 1949;35(suppl 1):267-272.
6. Flint J, Hill AV, Bowden DK, et al. High frequencies of alpha-thalassaemia are the result of natural selection by malaria. Nature. 1986;321:744-750.
7. +- Thalassemia protects children against disease caused by other infections as well as malaria. Proc Natl Acad Sci USA. 1997;94:14736-14741.
8. Modiano G, Morpurgo G, Terrenato L, et al. Protection against malaria morbidity: near-fixation of the α-thalassemia gene in a Nepalese population. Am J Hum Genet. 1991;48:390-397.
9. Mockenhaupt FP, Bienzle U, May J, et al. Plasmodium falciparum infection: influence on hemoglobin levels in alpha-thalassemia and microcytosis. J Infect Dis. 1999;180:925-928.
10. Allen SJ, Rowe P, Allsopp CE, et al. A prospective study of the influence of alpha thalassaemia on morbidity from malaria and immune responses to defined Plasmodium falciparum antigens in Gambian children. Trans R Soc Trop Med Hyg. 1993;87:282-285.
11. Mockenhaupt FP, Ehrhardt S, Burkhardt J, et al. Manifestation and outcome of severe malaria in children in northern Ghana. Am J Trop Med Hyg. 2004;71:XXX-XXX.
12. Djimde A, Doumbo OK, Cortese JF, et al. A molecular marker of chloroquine-resistant falciparum malaria. N Engl J Med. 2001;344:257-262.
13. Liu YT, Old JM, Miles K, Fisher CA, Weatherall DJ, Clegg JB. Rapid detection of alpha-thalassaemia deletions and alpha-globin gene triplication by multiplex polymerase chain reactions. Br J Haematol. 2000;108:295-299.
14. Allison AC. Polymorphism and natural selection in human populations. Cold Spring Harb Symp Quant Biol. 1964;29:137-149.
15. Williams TN, Maitland K, Bennett S, et al. High incidence of malaria in alpha-thalassaemic children. Nature. 1996;383:522-525.
16. Mockenhaupt FP, Ehrhardt S, Otchwemah R, et al. Limited influence of haemoglobin variants on Plasmodium falciparum msp1 and msp2 alleles in symptomatic malaria. Trans R Soc Trop Med Hyg. 2004;98:302-310.
17. Carlson J, Nash GB, Gabutti V, al-Yaman F, Wahlgren M. Natural protection against severe Plasmodium falciparum malaria due to impaired rosette formation. Blood. 1994;84:3909-3914.
18. Luzzi GA, Torii M, Aikawa M, Pasvol G. Unrestricted growth of Plasmodium falciparum in microcytic erythrocytes in iron deficiency and thalassaemia. Br J Haematol. 1990;74:519-524.
19. Senok AC, Li K, Nelson EA, Arumanayagam M, Li CK. Flow cytometric assessment of oxidant stress in age-fractionated thalassaemic trait erythrocytes and its relationship to in vitro growth of Plasmodium falciparum. Parasitology. 1998;116:1-6.
20. Pattanapanyasat K, Yongvanitchit K, Tongtawe P, et al. Impairment of Plasmodium falciparum growth in thalassemic red blood cells: further evidence by using biotin labeling and flow cytometry. Blood. 1999;93:3116-3119.
21. Luzzi GA, Merry AH, Newbold CI, Marsh K, Pasvol G, Weatherall DJ. Surface antigen expression on Plasmodium falciparum-infected erythrocytes is modified in α- and β-thalassemia. J Exp Med. 1991;173:785-791.