α+-thalassemia protects against anemia associated with asymptomatic malaria: Evidence from community-based surveys in Tanzania and Kenya

Journal of Infectious Diseases

Volumn 198, Issue 3, 2008, Pages 401-408

  Veenemans, Jacobien ^a   Andang'O, Pauline E A ^a   Mbugi, Erasto V ^a   Kraaijenhagen, Rob J ^b   Mwaniki, David L ^e   Mockenhaupt, Frank P ^d   Roewer, Susanne ^d   Olomi, Raimos M ^f   Shao, John F ^f   Van Der Meer, Jos W M ^c   Savelkoul, Huub F J ^a   Verhoef, Hans ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b MEANDER MEDICAL CENTER   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e Kenyan Institute of Medical Research   (Kenya)

^f KILIMANJARO CHRISTIAN MEDICAL CENTRE   (Tanzania)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLOBIN; C REACTIVE PROTEIN; HEMOGLOBIN;

AGE; ALPHA THALASSEMIA; ANEMIA; ARTICLE; CONFIDENCE INTERVAL; DISEASE ASSOCIATION; GENOTYPE; HEALTH SURVEY; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; INFLAMMATION; IRON DEFICIENCY; KENYA; MALARIA; PLASMODIUM FALCIPARUM; PRESCHOOL CHILD; PRIORITY JOURNAL; TANZANIA;

ALPHA-THALASSEMIA; ANEMIA; ANIMALS; CHILD; CHILD, PRESCHOOL; GLOBINS; HEMOGLOBINS; HUMANS; IMMUNITY, INNATE; INFANT; KENYA; MALARIA; TANZANIA;

EID: 48749097988     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/589884     Document Type: Article

References (37)

1. Weatherall DJ, Clegg JB. The thalassaemia syndromes. 4th ed. Oxford: Blackwell Science, 2001.
2. +-thalassaemia to anaemia in a Nigerian population exposed to intense malaria transmission. Trop Med Int Health 1999; 4:302-7.
3. + thalassaemias from early childhood to maturity. Br J Haematol 1996; 95:266-72.
4. + thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya. Blood 2005; 106:368-71.
5. +- Thalassemia protects children against disease caused by other infections as well as malaria. Proc Natl Acad Sci USA 1997; 94:14736-41.
6. May J, Evans JA, Timmann C, et al. Hemoglobin variants and disease manifestations in severe falciparum malaria. JAMA 2007; 297:2220-6.
7. +- Thalassemia protects African children from severe malaria. Blood 2004; 104:2003-6.
8. +- thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya. PLoS Med 2006; 3:e158.
9. +-thalassemia and the sickle cell trait. Nat Genet 2005; 37:1253-7.
10. Williams TN, Maitland K, Bennett S, et al. High incidence of malaria in alpha-thalassaemic children. Nature 1996; 383:522-5.
11. Williams TN. Red blood cell defects and malaria. Mol Biochem Parasitol 2006; 149:121-7.
12. Pasvol G. Does α+-thalassemia protect against malaria? Plos Med 2006; 3:e235.
13. Ekvall H, Arese P, Turrini F, et al. Acute haemolysis in childhood falciparum malaria. Trans R Soc Trop Med Hyg 2001; 95:611-7.
14. Ekvall H. Malaria and anemia. Curr Opin Hematol 2003;10:108-14.
15. Casals-Pascual C, Roberts DJ. Severe malarial anaemia. Curr Mol Med 2006; 6:155-68.
16. Koram KA, Owusu-Agyei S, Utz G, et al. Severe anemia in young children after high and low malaria transmission seasons in the Kassena-nankana district of northern Ghana. Am J Trop Med Hyg 2000; 62:670-4.
17. Ong'chega JM, Keller CC, Were T, et al. Parasitemia, anemia and malarial anemia in infants and young children in a rural holoendemic P. falciparum transmission area. Am J Trop Med Hyg 2006; 74:376-85.
18. Mockenhaupt FP. Manifestation and outcome of severe malaria in children in northern Ghana. Am J Trop Med Hyg 2004; 71:167-72.
19. Biemba G, Dolmans D, Thuma PE, Weiss G, Gordeuk VD. Severe anemia in Zambian children with Plasmodium falciparum malaria. Trop Med Int Health 2000; 5:9-16.
20. Oppenheimer SJ, Hill AV, Gibson FD, Macfarlane SB, Moody JB, Pringle J. The interaction of alpha thalassaemia with malaria. Trans R Soc Trop Med Hyg 1987; 81:322-6.
21. Mockenhaupt FP, Bienzle U, May J, et al. Plasmodium falciparum infection: influence on hemoglobin levels in alpha-thalassemia and microcytosis. J Infect Dis 1999; 180:925-8.
22. Mockenhaupt FP, Rong B, Gunther M, et al. Anaemia in pregnant Ghanaian women: importance of malaria, iron deficiency, and haemoglobinopathies. Trans R Soc Trop Med Hyg 2000; 94:477-83.
23. Andang'o PE, Osendarp SJ, Ayah R, et al. Efficacy of iron-fortified whole maize flour on iron status of schoolchildren in Kenya: a randomised controlled trial. Lancet 2007; 369:1799-1806.
24. Makler MT, Piper RC, Milhous WK. Lactate dehydrogenase and the diagnosis of malaria. Parasitol Today 1998; 14:376-7.
25. Piper R, Lebras J, Wentworth L, et al. Immunocapture diagnostic assays for malaria using Plasmodium lactate dehydrogenase (pLDH). Am J Trop Med Hyg 1999; 60:109-18.
26. Liu YT, Old JM, Miles K, Fisher CA, Weatherall DJ, Clegg JB. Rapid detection of alpha-thalassaemia deletions and alpha-globin gene triplication by multiplex polymerase chain reactions. Br J Haematol 2000; 108:295-9.
27. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999; 340:448-54.
28. World Health Organization. Iron deficiency anaemia assessment, prevention and control: a guide for programme managers. Geneva: World Health Organization, 2001.
29. +-thalassemic women. Am J Trop Med Hyg 2001; 64:6-8.
30. Urban BC, Shafi MJ, Cordery DV, et al. Frequencies of peripheral blood myeloid cells in healthy Kenyan children with α+ thalassemia and the sickle cell trait. Am J Trop Med Hyg 2006;74:578-84.
31. Cockburn IA, Mackinnon MJ, O'Donnell A, et al. A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria. Proc Natl Acad Sci USA 2004; 101:272-7.
32. Hurt N, Smith T, Teuscher T, Tanner M. Do high levels of C-reactive protein in Tanzanian children indicate malaria morbidity? Clin Diagn Lab Immunol 1994; 1:437-44.
33. Nemeth E, Ganz T. Regulation of iron metabolism by hepcidin. Annu Rev Nutr 2006; 26:323-43.
34. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005; 352:1011-23.
35. Kurtzhals JAL, Helleberg M, Goka BQ, Akanmori BD. Severe malaria in West African children. Lancet 2003; 361:1393.
36. Camacho LH, Gordeuk VR, Wilairatana P, Pootrakul P, Brittenham GM, Looareesuwan S. The course of anemia after the treatment of acute, falciparum malaria. Ann Trop Med Parasitol 1998; 92:525-37.
37. Helleberg M, Bamenla QG, Bartholomew DA, George OA, Rodriques O, Kurtzhals JAL. Bone marrow suppression and severe anaemia associated with persistent Plasmodium falciparum infection in African children with microscopically undetectable parasitemia. Malar J 2005; 4:56.