Increasing αvβ3 selectivity of the anti-angiogenic drug cilengitide by N-methylation

Angewandte Chemie - International Edition

Volumn 50, Issue 40, 2011, Pages 9496-9500

  Mas Moruno, Carlos ^a   Beck, Johannes G ^a   Doedens, Lucas ^a   Frank, Andreas O ^a   Marinelli, Luciana ^c   Cosconati, Sandro ^c   Novellino, Ettore ^c   Kessler, Horst ^a,b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

conformational studies; cyclic peptides; integrin; N methylation; receptor selectivity

Indexed keywords

AMIDE BOND; CONFORMATIONAL STUDY; CYCLIC PEPTIDES; INTEGRINS; N-METHYLATION; STRUCTURAL CHANGE;

AMIDES; METHYLATION; PEPTIDES;

ALKYLATION;

ALPHAVBETA5 INTEGRIN; ANGIOGENESIS INHIBITOR; CILENGITIDE; CYCLOPEPTIDE; SNAKE VENOM; VITRONECTIN RECEPTOR;

ARTICLE; CHEMISTRY; METABOLISM; METHYLATION; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; PEPTIDE LIBRARY; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

ANGIOGENESIS INHIBITORS; INTEGRIN ALPHAVBETA3; METHYLATION; MOLECULAR DYNAMICS SIMULATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE LIBRARY; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; RECEPTORS, VITRONECTIN; SNAKE VENOMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80053161003     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201102971     Document Type: Article

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