Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 38, 2011, Pages 15960-15965

  Wang, Xin Xiang ^a,b   Li, Yili ^a,b   Yin, Yiyuan ^a,c   Mo, Min ^a   Wang, Qian ^a,b   Gao, Wei ^a   Wang, Lili ^d   Mariuzza, Roy A ^a,b  

^a UNIVERSITY OF MARYLAND   (United States)

^b Bldg 142   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

^d NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; HLA DP ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN; HLA DR1 ANTIGEN; MONOMER; MUTANT PROTEIN; TETRAMER;

ANTIGEN BINDING; ANTIGEN RECOGNITION; ANTIGEN STRUCTURE; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL MATURATION; CRYSTAL STRUCTURE; GENE ISOLATION; GENE LIBRARY; GENE MUTATION; GENETIC POLYMORPHISM; IN VITRO STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II; MOLECULAR CLONING; MUTAGENESIS; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN DOMAIN; T LYMPHOCYTE ACTIVATION; WILD TYPE; YEAST;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD4; BINDING SITES; BINDING, COMPETITIVE; CELL LINE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; HIV ENVELOPE PROTEIN GP120; HLA-DR1 ANTIGEN; HUMANS; MODELS, MOLECULAR; MUTATION; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SPODOPTERA; SURFACE PLASMON RESONANCE; YEASTS;

EID: 80053152162     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1109438108     Document Type: Article

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