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Volumn 1, Issue 6, 2010, Pages 499-505

Reversal of age-dependent nuclear morphology by inhibition of prenylation does not affect lifespan in Caenorhabditis elegans

Author keywords

Farnesyl transferase inhibitor; Lamin; Motility; Nuclear structure; Nucleau envelope

Indexed keywords

GLIOTOXIN; LAMIN A; MANUMYCIN; PROTEIN FARNESYLTRANSFERASE INHIBITOR;

EID: 78549283099     PISSN: 19491034     EISSN: 19491042     Source Type: Journal    
DOI: 10.4161/nucl.1.6.13223     Document Type: Article
Times cited : (16)

References (39)
  • 1
    • 0031686054 scopus 로고    scopus 로고
    • Nuclear lamins: Their structure, assembly and interactions
    • Stuurman N, Heins S, Aebi U. Nuclear lamins: their structure, assembly and interactions. J Struct Biol 1998; 122:42-66.
    • (1998) J Struct Biol , vol.122 , pp. 42-66
    • Stuurman, N.1    Heins, S.2    Aebi, U.3
  • 7
    • 33846484332 scopus 로고    scopus 로고
    • Human progeroid syndromes, aging and cancer: New genetic and epigenetic insights into old questions
    • Ramírez CL, Cadiñanos J, Varela I, Freije JM, López- Otín C. Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions. Cell Mol Life Sci 2007; 64:155-70.
    • (2007) Cell Mol Life Sci , vol.64 , pp. 155-170
    • Ramírez, C.L.1    Cadiñanos, J.2    Varela, I.3    Freije, J.M.4    López-Otín, C.5
  • 10
    • 17644373758 scopus 로고    scopus 로고
    • Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome
    • Scaffidi P, Misteli T. Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nat Med 2005; 11:440-5.
    • (2005) Nat Med , vol.11 , pp. 440-445
    • Scaffidi, P.1    Misteli, T.2
  • 11
    • 33645060977 scopus 로고    scopus 로고
    • A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria
    • Fong LG, Frost D, M M, Qiao X, Yang SH, Coffinier C, Young SG. A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria. Science 2006; 311:1621-3.
    • (2006) Science , vol.311 , pp. 1621-1623
    • Fong, L.G.1    Frost, D.M.M.2    Qiao, X.3    Yang, S.H.4    Coffinier, C.5    Young, S.G.6
  • 13
    • 33746715642 scopus 로고    scopus 로고
    • A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation
    • Yang SH, Meta M, Qiao X, Frost D, Bauch J, Coffinier C, et al. A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation. J Clin Invest 2006; 116:2115-21.
    • (2006) J Clin Invest , vol.116 , pp. 2115-2121
    • Yang, S.H.1    Meta, M.2    Qiao, X.3    Frost, D.4    Bauch, J.5    Coffinier, C.6
  • 14
    • 46849106102 scopus 로고    scopus 로고
    • Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging
    • Varela I, Pereira S, Ugalde AP, Navarro CL, Suárez MF, Cau P, et al. Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging. Nat Med 2008; 14:767-72.
    • (2008) Nat Med , vol.14 , pp. 767-772
    • Varela, I.1    Pereira, S.2    Ugalde, A.P.3    Navarro, C.L.4    Suárez, M.F.5    Cau, P.6
  • 15
    • 34247356070 scopus 로고    scopus 로고
    • A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells
    • Cao K, Capell BC, Erdos MR, Djabali K, Collins FS. A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells. Proc Natl Acad Sci USA 2007; 104:3939-54.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 3939-3954
    • Cao, K.1    Capell, B.C.2    Erdos, M.R.3    Djabali, K.4    Collins, F.S.5
  • 16
    • 41649101975 scopus 로고    scopus 로고
    • The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin
    • McClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS, Djabali K. The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin. PLoS One 2007; 2:1269.
    • (2007) PLoS One , vol.2 , pp. 1269
    • McClintock, D.1    Ratner, D.2    Lokuge, M.3    Owens, D.M.4    Gordon, L.B.5    Collins, F.S.6    Djabali, K.7
  • 17
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • Brenner S. The genetics of Caenorhabditis elegans. Genetics 1974; 77:71-94.
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 20
    • 70349493024 scopus 로고    scopus 로고
    • Gliotoxin reverses age-dependent nuclear morphology phenotypes, ameliorates motility, but fails to affect lifespan of adult Caenorhabditis elegans
    • Bar DZ, Neufeld E, Feinstein N, Gruenbaum Y. Gliotoxin reverses age-dependent nuclear morphology phenotypes, ameliorates motility, but fails to affect lifespan of adult Caenorhabditis elegans. Cell Motil Cytoskeleton 2009; 66:791-7.
    • (2009) Cell Motil Cytoskeleton , vol.66 , pp. 791-797
    • Bar, D.Z.1    Neufeld, E.2    Feinstein, N.3    Gruenbaum, Y.4
  • 21
    • 34547927824 scopus 로고    scopus 로고
    • Barrier to autointegration factor blocks premature cell fusion and maintains adult muscle integrity in C. elegans
    • Margalit A, Neufeld E, Feinstein N, Wilson KL, Podbilewicz B, Gruenbaum Y. Barrier to autointegration factor blocks premature cell fusion and maintains adult muscle integrity in C. elegans. J Cell Biol 2007; 178:661-73.
    • (2007) J Cell Biol , vol.178 , pp. 661-673
    • Margalit, A.1    Neufeld, E.2    Feinstein, N.3    Wilson, K.L.4    Podbilewicz, B.5    Gruenbaum, Y.6
  • 23
    • 48249123448 scopus 로고    scopus 로고
    • The Parallel Worm Tracker: A platform for measuring average speed and drug-induced paralysis in nematodes
    • Ramot D, Johnson BE, Berry TLJ, Carnell L, Goodman MB. The Parallel Worm Tracker: a platform for measuring average speed and drug-induced paralysis in nematodes. PLoS One 2008; 3:2208.
    • (2008) PLoS One , vol.3 , pp. 2208
    • Ramot, D.1    Johnson, B.E.2    Berry, T.L.J.3    Carnell, L.4    Goodman, M.B.5
  • 24
    • 0037228016 scopus 로고    scopus 로고
    • A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
    • Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 2003; 33:40-8.
    • (2003) Nat Genet , vol.33 , pp. 40-48
    • Lee, S.S.1    Lee, R.Y.2    Fraser, A.G.3    Kamath, R.S.4    Ahringer, J.5    Ruvkun, G.6
  • 25
    • 0028898579 scopus 로고
    • Ras farnesyltransferase inhibitors suppress the phenotype resulting from an activated ras mutation in Caenorhabditis elegans
    • Hara M, Han M. Ras farnesyltransferase inhibitors suppress the phenotype resulting from an activated ras mutation in Caenorhabditis elegans. Proc Natl Acad Sci USA 1995; 92:3333-7.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3333-3337
    • Hara, M.1    Han, M.2
  • 28
    • 30844434561 scopus 로고    scopus 로고
    • Zmpste24, misshapen cell nuclei and progeria-New evidence suggesting that protein farnesylation could be important for disease pathogenesis
    • Young SG, Fong LG, Michaelis S, Prelamin A, Zmpste24, misshapen cell nuclei and progeria-New evidence suggesting that protein farnesylation could be important for disease pathogenesis. J Lipid Res 2005; 46:2531-58.
    • (2005) J Lipid Res , vol.46 , pp. 2531-2558
    • Young, S.G.1    Fong, L.G.2    Michaelis, S.3    Prelamin, A.4
  • 29
    • 33748993124 scopus 로고    scopus 로고
    • Molecular bases of progeroid syndromes
    • Navarro CL, Cau P, Lévy N. Molecular bases of progeroid syndromes. Hum Mol Genet 2006; 2:151-61.
    • (2006) Hum Mol Genet , vol.2 , pp. 151-161
    • Navarro, C.L.1    Cau, P.2    Lévy, N.3
  • 31
    • 26444463068 scopus 로고    scopus 로고
    • Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome
    • Mallampalli MP, Huyer G, Bendale P, Gelb MH, Michaelis S. Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci USA 2005; 102:14416-21.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 14416-14421
    • Mallampalli, M.P.1    Huyer, G.2    Bendale, P.3    Gelb, M.H.4    Michaelis, S.5
  • 32
    • 22544440839 scopus 로고    scopus 로고
    • Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation
    • Yang SH, Bergo MO, Toth JI, Qiao X, Hu Y, Sandoval S, et al. Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation. Proc Natl Acad Sci USA 2005; 102:10291-6.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 10291-10296
    • Yang, S.H.1    Bergo, M.O.2    Toth, J.I.3    Qiao, X.4    Hu, Y.5    Sandoval, S.6
  • 33
    • 12344259997 scopus 로고    scopus 로고
    • Intranuclear membrane structure formations by CaaX-containing nuclear proteins
    • Ralle T, Grund C, Franke WW, Stick R. Intranuclear membrane structure formations by CaaX-containing nuclear proteins. J Cell Sci 2004; 117:6095-104.
    • (2004) J Cell Sci , vol.117 , pp. 6095-6104
    • Ralle, T.1    Grund, C.2    Franke, W.W.3    Stick, R.4
  • 34
    • 38949154474 scopus 로고    scopus 로고
    • Filaments made from A- and B-type lamins differ in structure and organization
    • Goldberg MW, Huttenlauch I, Hutchison CJ, Stick R. Filaments made from A- and B-type lamins differ in structure and organization. J Cell Sci 2008; 121:215-225.
    • (2008) J Cell Sci , vol.121 , pp. 215-225
    • Goldberg, M.W.1    Huttenlauch, I.2    Hutchison, C.J.3    Stick, R.4
  • 35
    • 12344326099 scopus 로고    scopus 로고
    • The lamin CxxM motif promotes nuclear membrane growth
    • Prufert K, Vogel A, Krohne G. The lamin CxxM motif promotes nuclear membrane growth. J Cell Sci 2004; 117:6105-16.
    • (2004) J Cell Sci , vol.117 , pp. 6105-6116
    • Prufert, K.1    Vogel, A.2    Krohne, G.3
  • 37
    • 79956088863 scopus 로고    scopus 로고
    • The measurement and analysis of age-related changes in Caenorhabditis elegans
    • Ed. The C. elegans Research Community, WormBook; DOI/101895/wormbook11371
    • Collins JJ, Huang C, Hughe S, Kornfeld K. The measurement and analysis of age-related changes in Caenorhabditis elegans. WormBook, Ed. The C. elegans Research Community, WormBook; DOI/101895/ wormbook11371, http://wwwwormbookorg2008.
    • WormBook
    • Collins, J.J.1    Huang, C.2    Hughe, S.3    Kornfeld, K.4
  • 39
    • 33845998966 scopus 로고    scopus 로고
    • Prelamin a farnesylation and progeroid syndromes
    • Young SG, Meta M, Yang SH, Fong LG. Prelamin a farnesylation and progeroid syndromes. J Biol Chem 2006; 281:39741-5.
    • (2006) J Biol Chem , vol.281 , pp. 39741-39745
    • Young, S.G.1    Meta, M.2    Yang, S.H.3    Fong, L.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.