메뉴 건너뛰기




Volumn 256, Issue 2, 2011, Pages 136-145

A non-invasive approach to study lifetime exposure and bioaccumulation of PCBs in protected marine mammals: PBPK modeling in harbor porpoises

Author keywords

Harbor porpoises; Metabolism; PBPK models; PCBs; Time trends

Indexed keywords

POLYCHLORINATED BIPHENYL 101; POLYCHLORINATED BIPHENYL 118; POLYCHLORINATED BIPHENYL 149; POLYCHLORINATED BIPHENYL 170; POLYCHLORINATED BIPHENYL 180; POLYCHLORINATED BIPHENYL 99; POLYCHLORINATED BIPHENYL DERIVATIVE; UNCLASSIFIED DRUG;

EID: 80053131882     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.07.020     Document Type: Article
Times cited : (16)

References (63)
  • 3
    • 0033029143 scopus 로고    scopus 로고
    • Factors affecting organochlorine contaminant concentrations in milk and blood of northern fur seal (Callorhinus ursinus) dams and pups from St. George Island, Alaska
    • Beckmen K.B., Ylitalo G.M., Towell R.G., Krahn M.M., O'Hara T.M., Blake J.E. Factors affecting organochlorine contaminant concentrations in milk and blood of northern fur seal (Callorhinus ursinus) dams and pups from St. George Island, Alaska. Sci. Total Environ. 1999, 231:183-200.
    • (1999) Sci. Total Environ. , vol.231 , pp. 183-200
    • Beckmen, K.B.1    Ylitalo, G.M.2    Towell, R.G.3    Krahn, M.M.4    O'Hara, T.M.5    Blake, J.E.6
  • 5
    • 77954423708 scopus 로고    scopus 로고
    • Organochlorine residues in South American sea lions, Otaria flavescens (Shaw, 1800): bioaccumulation and time trends
    • Borrell A., Garcia-Solà A., Aguilar A., Garcia N.A., Crespo E.A. Organochlorine residues in South American sea lions, Otaria flavescens (Shaw, 1800): bioaccumulation and time trends. Bull. Environ. Contam. Toxicol. 2010, 84:731-737.
    • (2010) Bull. Environ. Contam. Toxicol. , vol.84 , pp. 731-737
    • Borrell, A.1    Garcia-Solà, A.2    Aguilar, A.3    Garcia, N.A.4    Crespo, E.A.5
  • 8
    • 37549042390 scopus 로고    scopus 로고
    • Development and specification of physiologically based pharmacokinetic models for use in risk assessment
    • Clewell R.A., Clewell H.J. Development and specification of physiologically based pharmacokinetic models for use in risk assessment. Regul. Toxicol. Pharmacol. 2008, 50:129-143.
    • (2008) Regul. Toxicol. Pharmacol. , vol.50 , pp. 129-143
    • Clewell, R.A.1    Clewell, H.J.2
  • 10
    • 0036804012 scopus 로고    scopus 로고
    • Determination of organohalogenated contaminants in liver of harbour porpoises (Phocoena phocoena) stranded on the Belgian North Sea coast
    • Covaci A., Van de Vijver K., De Coen W., Das K., Bouquegneau J.M., Blust R., Schepens P. Determination of organohalogenated contaminants in liver of harbour porpoises (Phocoena phocoena) stranded on the Belgian North Sea coast. Mar. Pollut. Bull. 2002, 44:1157-1169.
    • (2002) Mar. Pollut. Bull. , vol.44 , pp. 1157-1169
    • Covaci, A.1    Van de Vijver, K.2    De Coen, W.3    Das, K.4    Bouquegneau, J.M.5    Blust, R.6    Schepens, P.7
  • 11
    • 0037418106 scopus 로고    scopus 로고
    • Dynamics of PCB transfer from mother to pup during lactation in UK grey seals Halichoerus grypus: differences in PCB profile between compartments of transfer and changes during the lactation period
    • Debier C., Pomeroy P.P., Dupont C., Joiris C., Comblin V., Le Boulengé E., Larondelle Y., Thomé J.P. Dynamics of PCB transfer from mother to pup during lactation in UK grey seals Halichoerus grypus: differences in PCB profile between compartments of transfer and changes during the lactation period. Mar. Ecol. Prog. Ser. 2003, 247:249-256.
    • (2003) Mar. Ecol. Prog. Ser. , vol.247 , pp. 249-256
    • Debier, C.1    Pomeroy, P.P.2    Dupont, C.3    Joiris, C.4    Comblin, V.5    Le Boulengé, E.6    Larondelle, Y.7    Thomé, J.P.8
  • 12
    • 5044248840 scopus 로고    scopus 로고
    • Seasonal and temporal trends in polychlorinated biphenyls and organochlorine pesticides in East Greenland polar bears (Ursus maritimus), 1990-2001
    • Dietz R., Riget F.F., Sonne C., Letcher R., Born E.W., Muir D.C.G. Seasonal and temporal trends in polychlorinated biphenyls and organochlorine pesticides in East Greenland polar bears (Ursus maritimus), 1990-2001. Sci. Total Environ. 2004, 331:107-124.
    • (2004) Sci. Total Environ. , vol.331 , pp. 107-124
    • Dietz, R.1    Riget, F.F.2    Sonne, C.3    Letcher, R.4    Born, E.W.5    Muir, D.C.G.6
  • 13
    • 0032037129 scopus 로고    scopus 로고
    • Blood-brain barrier disruption for the treatment of malignant brain tumors: the national program
    • Doolittle N.D., Petrillo A., Bell S., Cummings P., Eriksen S. Blood-brain barrier disruption for the treatment of malignant brain tumors: the national program. J. Neurosci. Nurs. 1998, 30:81-90.
    • (1998) J. Neurosci. Nurs. , vol.30 , pp. 81-90
    • Doolittle, N.D.1    Petrillo, A.2    Bell, S.3    Cummings, P.4    Eriksen, S.5
  • 14
    • 77649341210 scopus 로고    scopus 로고
    • Comparative sensitivity of harbour and grey seals to several environmental contaminants using in vitro exposure
    • Dufresne M.M., Frouin H., Pillet S., Lesage V., De Guise S., Fournier M. Comparative sensitivity of harbour and grey seals to several environmental contaminants using in vitro exposure. Mar. Pollut. Bull. 2010, 60:344-349.
    • (2010) Mar. Pollut. Bull. , vol.60 , pp. 344-349
    • Dufresne, M.M.1    Frouin, H.2    Pillet, S.3    Lesage, V.4    De Guise, S.5    Fournier, M.6
  • 16
    • 0032742582 scopus 로고    scopus 로고
    • Lifetime pharmacokinetic model for hydrophobic contaminants in marine mammals
    • Hickie B.E., Mackay D., de Koning J. Lifetime pharmacokinetic model for hydrophobic contaminants in marine mammals. Environ. Toxicol. Chem. 1999, 18:2622-2633.
    • (1999) Environ. Toxicol. Chem. , vol.18 , pp. 2622-2633
    • Hickie, B.E.1    Mackay, D.2    de Koning, J.3
  • 17
    • 34447558488 scopus 로고    scopus 로고
    • Molecular characterization of cytochrome P450 1A1, 1A2, and 1B1, and effects of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners on their hepatic expression in Baikal seal (Pusa sibirica)
    • Hirakawa S., Iwata H., Takeshita Y., Kim E.Y., Sakamoto T., Okajima Y., Amano M., Miyazaki N., Petrov E.A., Tanabe S. Molecular characterization of cytochrome P450 1A1, 1A2, and 1B1, and effects of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners on their hepatic expression in Baikal seal (Pusa sibirica). Toxicol. Sci. 2007, 97:318-335.
    • (2007) Toxicol. Sci. , vol.97 , pp. 318-335
    • Hirakawa, S.1    Iwata, H.2    Takeshita, Y.3    Kim, E.Y.4    Sakamoto, T.5    Okajima, Y.6    Amano, M.7    Miyazaki, N.8    Petrov, E.A.9    Tanabe, S.10
  • 18
    • 3242668652 scopus 로고    scopus 로고
    • Polybrominated diphenyl ethers and organochlorines in archived Northern fur seal samples from the Pacific coast of Japan, 1972-1998
    • Kajiwara N., Ueno D., Takahashi A., Baba N., Tanabe S. Polybrominated diphenyl ethers and organochlorines in archived Northern fur seal samples from the Pacific coast of Japan, 1972-1998. Environ. Sci. Technol. 2004, 38:3804-3809.
    • (2004) Environ. Sci. Technol. , vol.38 , pp. 3804-3809
    • Kajiwara, N.1    Ueno, D.2    Takahashi, A.3    Baba, N.4    Tanabe, S.5
  • 19
    • 33847347398 scopus 로고    scopus 로고
    • Phylogenetic, ecological, and ontogenetic factors influencing the biochemical structure of the blubber of Odontocetes
    • Koopman H.N. Phylogenetic, ecological, and ontogenetic factors influencing the biochemical structure of the blubber of Odontocetes. Mar. Biol. 2007, 151:277-291.
    • (2007) Mar. Biol. , vol.151 , pp. 277-291
    • Koopman, H.N.1
  • 20
    • 77649340578 scopus 로고    scopus 로고
    • Chlorobiphenyls in the blubber of harbour porpoises (Phocoena phocoena) from the UK: Levels and trends 1991-2005
    • Law R.J., Bersuder P., Barry J., Deaville R., Reid R.J., Jepson P.D. Chlorobiphenyls in the blubber of harbour porpoises (Phocoena phocoena) from the UK: Levels and trends 1991-2005. Mar. Pollut. Bull. 2010, 60:470-473.
    • (2010) Mar. Pollut. Bull. , vol.60 , pp. 470-473
    • Law, R.J.1    Bersuder, P.2    Barry, J.3    Deaville, R.4    Reid, R.J.5    Jepson, P.D.6
  • 21
    • 34447100100 scopus 로고    scopus 로고
    • Temporal trends (1987-2002) of persistent, bioaccumulative and toxic (PBT) chemicals in beluga whales (Delphinapterus leucas) from the St. Lawrence Estuary, Canada
    • Lebeuf M., Noël M., Trottier S., Measures L. Temporal trends (1987-2002) of persistent, bioaccumulative and toxic (PBT) chemicals in beluga whales (Delphinapterus leucas) from the St. Lawrence Estuary, Canada. Sci. Total Environ. 2007, 383:216-231.
    • (2007) Sci. Total Environ. , vol.383 , pp. 216-231
    • Lebeuf, M.1    Noël, M.2    Trottier, S.3    Measures, L.4
  • 22
    • 0036149778 scopus 로고    scopus 로고
    • Comparison of pharmacokinetic interactions and physiologically based pharmacokinetic modeling of PCB 153 and PCB 126 in nonpregnant mice, lactating mice, and suckling pups
    • Lee S.K., Ou Y.C., Yang R.S.H. Comparison of pharmacokinetic interactions and physiologically based pharmacokinetic modeling of PCB 153 and PCB 126 in nonpregnant mice, lactating mice, and suckling pups. Toxicol. Sci. 2002, 65:26-34.
    • (2002) Toxicol. Sci. , vol.65 , pp. 26-34
    • Lee, S.K.1    Ou, Y.C.2    Yang, R.S.H.3
  • 23
    • 0032101564 scopus 로고    scopus 로고
    • Biotranformation versus bioaccumulation: sources of methyl sulfone PCB and 4,4'-DDE metabolites in the polar bear food chain
    • Letcher R.J., Norstrom R.J., Muir D.C.G. Biotranformation versus bioaccumulation: sources of methyl sulfone PCB and 4,4'-DDE metabolites in the polar bear food chain. Environ. Sci. Technol. 1998, 32:1656-1661.
    • (1998) Environ. Sci. Technol. , vol.32 , pp. 1656-1661
    • Letcher, R.J.1    Norstrom, R.J.2    Muir, D.C.G.3
  • 24
    • 0242515904 scopus 로고    scopus 로고
    • Hepatic microsomal cytochrome P450 enzyme activity in relation to in vitro metabolism/inhibition of polychlorinated biphenyls and testosterone in Baltic grey seal (Halichoerus grypus)
    • Li H., Boon J.P., Lewis W.E., van den Berg M., Nyman M., Letcher R.J. Hepatic microsomal cytochrome P450 enzyme activity in relation to in vitro metabolism/inhibition of polychlorinated biphenyls and testosterone in Baltic grey seal (Halichoerus grypus). Environ. Toxicol. Chem. 2003, 22:636-644.
    • (2003) Environ. Toxicol. Chem. , vol.22 , pp. 636-644
    • Li, H.1    Boon, J.P.2    Lewis, W.E.3    van den Berg, M.4    Nyman, M.5    Letcher, R.J.6
  • 26
    • 0028971257 scopus 로고
    • Recalcitrant organochlorine compounds in captive bottlenose dolphins (Tursiops truncatus): biomagnification or bioaccumulation?
    • Marsili L., Gaggi C., Bortolotto A., Stanzani L., Franchi A., Renzoni A., Bacci E. Recalcitrant organochlorine compounds in captive bottlenose dolphins (Tursiops truncatus): biomagnification or bioaccumulation?. Chemosphere 1995, 31:3919-3932.
    • (1995) Chemosphere , vol.31 , pp. 3919-3932
    • Marsili, L.1    Gaggi, C.2    Bortolotto, A.3    Stanzani, L.4    Franchi, A.5    Renzoni, A.6    Bacci, E.7
  • 27
    • 33745683896 scopus 로고    scopus 로고
    • Estimated cancer risk of dioxins to humans using a bioassay and physiologically based pharmacokinetic model
    • Maruyama W., Aoki Y. Estimated cancer risk of dioxins to humans using a bioassay and physiologically based pharmacokinetic model. Toxicol. Appl. Pharmacol. 2006, 214:188-198.
    • (2006) Toxicol. Appl. Pharmacol. , vol.214 , pp. 188-198
    • Maruyama, W.1    Aoki, Y.2
  • 28
    • 33645237592 scopus 로고    scopus 로고
    • Biotransformation of polybrominated diphenyl ethers and polychlorinated biphenyls in beluga whale (Delphinapterus leucas) and rat mammalian model using an in vitro hepatic microsomal assay
    • McKinney M.A., De Guise S., Martineau D., Béland P., Arukwe A., Letcher R.J. Biotransformation of polybrominated diphenyl ethers and polychlorinated biphenyls in beluga whale (Delphinapterus leucas) and rat mammalian model using an in vitro hepatic microsomal assay. Aquat. Toxicol. 2006, 77:87-97.
    • (2006) Aquat. Toxicol. , vol.77 , pp. 87-97
    • McKinney, M.A.1    De Guise, S.2    Martineau, D.3    Béland, P.4    Arukwe, A.5    Letcher, R.J.6
  • 29
    • 14844283785 scopus 로고    scopus 로고
    • Assessment of cytochrome P450 1A in harbour seals (Phoca vitulina) using a minimally-invasive biopsy approach
    • Miller K.A., Assunção M.G.L., Dangerfield N.J., Bandiera S.M., Ross P.S. Assessment of cytochrome P450 1A in harbour seals (Phoca vitulina) using a minimally-invasive biopsy approach. Mar. Environ. Res. 2005, 60:153-169.
    • (2005) Mar. Environ. Res. , vol.60 , pp. 153-169
    • Miller, K.A.1    Assunção, M.G.L.2    Dangerfield, N.J.3    Bandiera, S.M.4    Ross, P.S.5
  • 30
    • 33847013740 scopus 로고    scopus 로고
    • Contaminant-associated disruption of vitamin A and its receptor (retinoic acid receptor ?) in free-ranging harbour seals (Phoca vitulina)
    • Mos L., Tabuchi M., Dangerfield N., Jeffries S.J., Koop B.F., Ross P.S. Contaminant-associated disruption of vitamin A and its receptor (retinoic acid receptor ?) in free-ranging harbour seals (Phoca vitulina). Aquat. Toxicol. 2007, 81:319-328.
    • (2007) Aquat. Toxicol. , vol.81 , pp. 319-328
    • Mos, L.1    Tabuchi, M.2    Dangerfield, N.3    Jeffries, S.J.4    Koop, B.F.5    Ross, P.S.6
  • 31
    • 0000549618 scopus 로고
    • Lipid class and fatty acid composition of brain lipids from Atlantic herring (Clupea harengus) at different stages of development
    • Mourente G., Tocher D.R. Lipid class and fatty acid composition of brain lipids from Atlantic herring (Clupea harengus) at different stages of development. Mar. Biol. 1992, 112:553-558.
    • (1992) Mar. Biol. , vol.112 , pp. 553-558
    • Mourente, G.1    Tocher, D.R.2
  • 32
    • 0031172737 scopus 로고    scopus 로고
    • Using structural information to create physiologically based pharmacokinetic models for all polychlorinated biphenyls. I. Tisue:blood partition coefficients
    • Parham F.M., Kohn M.C., Matthews H.B., DeRosa C., Portier C.J. Using structural information to create physiologically based pharmacokinetic models for all polychlorinated biphenyls. I. Tisue:blood partition coefficients. Toxicol. Appl. Pharmacol. 1997, 144:340-347.
    • (1997) Toxicol. Appl. Pharmacol. , vol.144 , pp. 340-347
    • Parham, F.M.1    Kohn, M.C.2    Matthews, H.B.3    DeRosa, C.4    Portier, C.J.5
  • 33
    • 58149356242 scopus 로고    scopus 로고
    • Population physiologically based pharmacokinetic modeling for the human lactational transfer of PCB-153 with consideration of worldwide human biomonitoring results
    • Redding L.E., Sohn M.D., McKone T.E., Chen J.W., Wang S.L., Hsieh D.P.H., Yang R.S.H. Population physiologically based pharmacokinetic modeling for the human lactational transfer of PCB-153 with consideration of worldwide human biomonitoring results. Environ. Health Perspect. 2008, 116:1629-1634.
    • (2008) Environ. Health Perspect. , vol.116 , pp. 1629-1634
    • Redding, L.E.1    Sohn, M.D.2    McKone, T.E.3    Chen, J.W.4    Wang, S.L.5    Hsieh, D.P.H.6    Yang, R.S.H.7
  • 35
    • 0022925905 scopus 로고
    • Reproductive failure in common seals feeding on fish from polluted coastal waters
    • Reijnders P.J.H. Reproductive failure in common seals feeding on fish from polluted coastal waters. Nature 1986, 324:456-457.
    • (1986) Nature , vol.324 , pp. 456-457
    • Reijnders, P.J.H.1
  • 36
    • 0023762297 scopus 로고
    • Physiologically based pharmacokinetic modeling with methylchloroform: implications for interspecies, high dose/low dose, and dose route extrapolations
    • Reitz R.H., McDougal J.N., Himmelstein M.W., Nolan R.J., Schumann A.M. Physiologically based pharmacokinetic modeling with methylchloroform: implications for interspecies, high dose/low dose, and dose route extrapolations. Toxicol. Appl. Pharmacol. 1988, 95:185-199.
    • (1988) Toxicol. Appl. Pharmacol. , vol.95 , pp. 185-199
    • Reitz, R.H.1    McDougal, J.N.2    Himmelstein, M.W.3    Nolan, R.J.4    Schumann, A.M.5
  • 37
    • 22844453347 scopus 로고    scopus 로고
    • Marine mammals as sentinels in ecological risk assessment
    • Ross P.S. Marine mammals as sentinels in ecological risk assessment. Hum. Ecol. Risk Assess. 2000, 6:1-18.
    • (2000) Hum. Ecol. Risk Assess. , vol.6 , pp. 1-18
    • Ross, P.S.1
  • 39
    • 57449093165 scopus 로고    scopus 로고
    • Biotransformation of PCBs in relation to phase I and phase II xenobiotic-metabolizing enzyme activities in ringed seals (Phoca hispida) from Svalbard and the Baltic Sea
    • Routti H., Letcher R.J., Arukwe A., Van Bavel B., Yoccoz N.G., Chu S., Gabrielsen G.W. Biotransformation of PCBs in relation to phase I and phase II xenobiotic-metabolizing enzyme activities in ringed seals (Phoca hispida) from Svalbard and the Baltic Sea. Environ. Sci. Technol. 2008, 42:8952-8958.
    • (2008) Environ. Sci. Technol. , vol.42 , pp. 8952-8958
    • Routti, H.1    Letcher, R.J.2    Arukwe, A.3    Van Bavel, B.4    Yoccoz, N.G.5    Chu, S.6    Gabrielsen, G.W.7
  • 40
    • 0142246589 scopus 로고    scopus 로고
    • Differential lipid affinity of xenobiotics and natural compounds
    • Sandermann H. Differential lipid affinity of xenobiotics and natural compounds. FEBS Lett. 2003, 554:165-168.
    • (2003) FEBS Lett. , vol.554 , pp. 165-168
    • Sandermann, H.1
  • 42
    • 0022001224 scopus 로고
    • Time trends of organochlorine chemical residues in seven sedentary marine fish species from a Norwegian fjord during the period 1972-1982
    • Skåre J.U., Stenersen J., Kveseth N., Polder A. Time trends of organochlorine chemical residues in seven sedentary marine fish species from a Norwegian fjord during the period 1972-1982. Arch. Environ. Contam. Toxicol. 1985, 14:33-41.
    • (1985) Arch. Environ. Contam. Toxicol. , vol.14 , pp. 33-41
    • Skåre, J.U.1    Stenersen, J.2    Kveseth, N.3    Polder, A.4
  • 43
    • 72049099608 scopus 로고    scopus 로고
    • Reproductive performance in East Greenland polar bears (Ursus maritimus) may be affected by organohalogen contaminants as shown by physiologically-based pharmacokinetic (PBPK) modeling
    • Sonne C., Gustavson K., Rigét F.F., Dietz R., Birkved M., Letcher R.J., Bossi R., Vorkamp K., Born E.W., Petersen G. Reproductive performance in East Greenland polar bears (Ursus maritimus) may be affected by organohalogen contaminants as shown by physiologically-based pharmacokinetic (PBPK) modeling. Chemosphere 2009, 77:1558-1568.
    • (2009) Chemosphere , vol.77 , pp. 1558-1568
    • Sonne, C.1    Gustavson, K.2    Rigét, F.F.3    Dietz, R.4    Birkved, M.5    Letcher, R.J.6    Bossi, R.7    Vorkamp, K.8    Born, E.W.9    Petersen, G.10
  • 44
    • 58149194792 scopus 로고    scopus 로고
    • PCBs in fish from the southern Baltic Sea: levels, bioaccumulation features, and temporal trends during the period from 1997 to 2006
    • Szlinder-Richert J., Barska I., Mazerski J., Usydus Z. PCBs in fish from the southern Baltic Sea: levels, bioaccumulation features, and temporal trends during the period from 1997 to 2006. Mar. Pollut. Bull. 2009, 58:85-92.
    • (2009) Mar. Pollut. Bull. , vol.58 , pp. 85-92
    • Szlinder-Richert, J.1    Barska, I.2    Mazerski, J.3    Usydus, Z.4
  • 46
    • 0037403468 scopus 로고    scopus 로고
    • Temporal trends of persistent organochlorine contamination in Russia: a case study of Baikal and Caspian seal
    • Tanabe S., Niimi S., Binh Minh T., Miyazaki N., Petrov E.A. Temporal trends of persistent organochlorine contamination in Russia: a case study of Baikal and Caspian seal. Arch. Environ. Contam. Toxicol. 2003, 44:533-545.
    • (2003) Arch. Environ. Contam. Toxicol. , vol.44 , pp. 533-545
    • Tanabe, S.1    Niimi, S.2    Binh Minh, T.3    Miyazaki, N.4    Petrov, E.A.5
  • 47
    • 7444220698 scopus 로고    scopus 로고
    • Absorption of decabromodiphenyl ether and other organohalogen chemicals by grey seals (Halichoerus grypus)
    • Thomas G.O., Moss S.E.W., Asplund L., Hall A. Absorption of decabromodiphenyl ether and other organohalogen chemicals by grey seals (Halichoerus grypus). Environ. Pollut. 2005, 133:581-586.
    • (2005) Environ. Pollut. , vol.133 , pp. 581-586
    • Thomas, G.O.1    Moss, S.E.W.2    Asplund, L.3    Hall, A.4
  • 48
    • 0030909485 scopus 로고    scopus 로고
    • Chemical contaminants in harbor porpoise (Phocoena phocoena) from the North Atlantic coast: tissue concentrations and intra-and interorgan distribution
    • Tilbury K.L., Stein J.E., Meador J.P., Krone C.A., Chan S.L. Chemical contaminants in harbor porpoise (Phocoena phocoena) from the North Atlantic coast: tissue concentrations and intra-and interorgan distribution. Chemosphere 1997, 34:2159-2181.
    • (1997) Chemosphere , vol.34 , pp. 2159-2181
    • Tilbury, K.L.1    Stein, J.E.2    Meador, J.P.3    Krone, C.A.4    Chan, S.L.5
  • 50
    • 0035996837 scopus 로고    scopus 로고
    • Isolation of two cytochrome P450 cDNAs, CYP1A1 and CYP1A2, from harp seal (Phoca groenlandica) and grey seal (Halichoerus grypus)
    • Tilley R.E., Kemp G.D., Teramitsu I., Hall A.J. Isolation of two cytochrome P450 cDNAs, CYP1A1 and CYP1A2, from harp seal (Phoca groenlandica) and grey seal (Halichoerus grypus). Comp. Biochem. Physiol. C 2002, 132:181-191.
    • (2002) Comp. Biochem. Physiol. C , vol.132 , pp. 181-191
    • Tilley, R.E.1    Kemp, G.D.2    Teramitsu, I.3    Hall, A.J.4
  • 51
    • 46749139544 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetic modeling of persistent organic pollutants for lifetime exposure assessment: a new tool in breast cancer epidemiologic studies
    • Verner M.A., Charbonneau M., Lopez-Carrillo L., Haddad S. Physiologically based pharmacokinetic modeling of persistent organic pollutants for lifetime exposure assessment: a new tool in breast cancer epidemiologic studies. Environ. Health Perspect. 2008, 116:886-892.
    • (2008) Environ. Health Perspect. , vol.116 , pp. 886-892
    • Verner, M.A.1    Charbonneau, M.2    Lopez-Carrillo, L.3    Haddad, S.4
  • 52
    • 8444253259 scopus 로고    scopus 로고
    • Levels and profiles of PCBs and OCPs in marine benthic species from the Belgian North Sea and the Western Scheldt Estuary
    • Voorspoels S., Covaci A., Maervoet J., De Meester I., Schepens P. Levels and profiles of PCBs and OCPs in marine benthic species from the Belgian North Sea and the Western Scheldt Estuary. Mar. Pollut. Bull. 2004, 49:393-404.
    • (2004) Mar. Pollut. Bull. , vol.49 , pp. 393-404
    • Voorspoels, S.1    Covaci, A.2    Maervoet, J.3    De Meester, I.4    Schepens, P.5
  • 53
    • 80053132791 scopus 로고    scopus 로고
    • Chapter 6: Toxicity testing
    • CRC Press, Taylor & Francis Group, USA, C.H. Walker, S.P. Hopkin, R.M. Sibly, D.B. Peakall (Eds.)
    • Walker C.H., Hopkin S.P., Sibly R.M., Peakall D.B. Chapter 6: Toxicity testing. Principles of Ecotoxicology 2006, 87-108. CRC Press, Taylor & Francis Group, USA. Third Edition. C.H. Walker, S.P. Hopkin, R.M. Sibly, D.B. Peakall (Eds.).
    • (2006) Principles of Ecotoxicology , pp. 87-108
    • Walker, C.H.1    Hopkin, S.P.2    Sibly, R.M.3    Peakall, D.B.4
  • 54
    • 57049138772 scopus 로고    scopus 로고
    • Inter-species differences for polychlorinated biphenyls and polybrominated diphenyl ethers in marine top predators from the Southern North Sea: Part 1. Accumulation patterns in harbour seals and harbour porpoises
    • Weijs L., Dirtu A.C., Das K., Gheorghe A., Reijnders P.J.H., Neels H., Blust R., Covaci A. Inter-species differences for polychlorinated biphenyls and polybrominated diphenyl ethers in marine top predators from the Southern North Sea: Part 1. Accumulation patterns in harbour seals and harbour porpoises. Environ. Pollut. 2009, 157:437-444.
    • (2009) Environ. Pollut. , vol.157 , pp. 437-444
    • Weijs, L.1    Dirtu, A.C.2    Das, K.3    Gheorghe, A.4    Reijnders, P.J.H.5    Neels, H.6    Blust, R.7    Covaci, A.8
  • 55
    • 57049179498 scopus 로고    scopus 로고
    • Inter-species differences for polychlorinated biphenyls and polybrominated diphenyl ethers in marine top predators from the Southern North Sea: Part 2. Biomagnification in harbour seals and harbour porpoises
    • Weijs L., Dirtu A.C., Das K., Gheorghe A., Reijnders P.J.H., Neels H., Blust R., Covaci A. Inter-species differences for polychlorinated biphenyls and polybrominated diphenyl ethers in marine top predators from the Southern North Sea: Part 2. Biomagnification in harbour seals and harbour porpoises. Environ. Pollut. 2009, 157:445-451.
    • (2009) Environ. Pollut. , vol.157 , pp. 445-451
    • Weijs, L.1    Dirtu, A.C.2    Das, K.3    Gheorghe, A.4    Reijnders, P.J.H.5    Neels, H.6    Blust, R.7    Covaci, A.8
  • 56
    • 77952952815 scopus 로고    scopus 로고
    • Occurrence of anthropogenic and naturally-produced organohalogenated compounds in tissues of Black Sea harbour porpoises
    • Weijs L., Das K., Neels H., Blust R., Covaci A. Occurrence of anthropogenic and naturally-produced organohalogenated compounds in tissues of Black Sea harbour porpoises. Mar. Pollut. Bull. 2010, 60:725-731.
    • (2010) Mar. Pollut. Bull. , vol.60 , pp. 725-731
    • Weijs, L.1    Das, K.2    Neels, H.3    Blust, R.4    Covaci, A.5
  • 57
    • 77956555217 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetic models for lifetime exposure to PCB 153 in male and female harbour porpoises (Phocoena phocoena): model development and validation
    • Weijs L., Yang R.S.H., Covaci A., Das K., Blust R. Physiologically based pharmacokinetic models for lifetime exposure to PCB 153 in male and female harbour porpoises (Phocoena phocoena): model development and validation. Environ. Sci. Technol. 2010, 44:7023-7030.
    • (2010) Environ. Sci. Technol. , vol.44 , pp. 7023-7030
    • Weijs, L.1    Yang, R.S.H.2    Covaci, A.3    Das, K.4    Blust, R.5
  • 58
    • 78149357015 scopus 로고    scopus 로고
    • Persistent organic pollutants and methoxylated PBDEs in harbour porpoises from the North Sea from 1990 until 2008: young wildlife at risk?
    • Weijs L., van Elk N., Das K., Neels H., Blust R., Covaci A. Persistent organic pollutants and methoxylated PBDEs in harbour porpoises from the North Sea from 1990 until 2008: young wildlife at risk?. Sci. Total Environ. 2010, 409:228-237.
    • (2010) Sci. Total Environ. , vol.409 , pp. 228-237
    • Weijs, L.1    van Elk, N.2    Das, K.3    Neels, H.4    Blust, R.5    Covaci, A.6
  • 59
    • 80053130753 scopus 로고    scopus 로고
    • Computational Toxicology: Physiologically based pharmacokinetic models (PBPK) for lifetime exposure and bioaccumulation of polybrominated diphenyl ethers (PBDEs) in marine mammals
    • (submitted for publication).
    • Weijs, L., Covaci, A., Yang, R.S.H., Das, K., Blust, R. Computational Toxicology: Physiologically based pharmacokinetic models (PBPK) for lifetime exposure and bioaccumulation of polybrominated diphenyl ethers (PBDEs) in marine mammals. Environ. Pol. (submitted for publication).
    • Environ. Pol.
    • Weijs, L.1    Covaci, A.2    Yang, R.S.H.3    Das, K.4    Blust, R.5
  • 60
    • 0033995640 scopus 로고    scopus 로고
    • Organochlorine exposure and bioaccumulation in the endangered Northwest Atlantic right whale (Eubalaena glacialis) population
    • Weisbrod A.V., Shea D., Moore M.J., Stegeman J.J. Organochlorine exposure and bioaccumulation in the endangered Northwest Atlantic right whale (Eubalaena glacialis) population. Environ. Toxicol. Chem. 2000, 19:654-666.
    • (2000) Environ. Toxicol. Chem. , vol.19 , pp. 654-666
    • Weisbrod, A.V.1    Shea, D.2    Moore, M.J.3    Stegeman, J.J.4
  • 61
    • 75149135091 scopus 로고    scopus 로고
    • Catalytic and immunochemical detection of hepatic and extrahepatic microsomal cytochrome P450 1A1 (CYP1A1) in white-sided dolphin (Lagenorhynchus acutus)
    • Wilson J.Y., Moore M.J., Stegeman J.J. Catalytic and immunochemical detection of hepatic and extrahepatic microsomal cytochrome P450 1A1 (CYP1A1) in white-sided dolphin (Lagenorhynchus acutus). Aquat. Toxicol. 2010, 96:216-224.
    • (2010) Aquat. Toxicol. , vol.96 , pp. 216-224
    • Wilson, J.Y.1    Moore, M.J.2    Stegeman, J.J.3
  • 62
    • 0032516329 scopus 로고    scopus 로고
    • Congener specific PCB and polychlorinated camphene (toxaphene) levels in Svalbard ringed seals (Phoca hispida) in relation to sex, age, condition and cytochrome P450 enzyme activity
    • Wolkers J., Burkow I.C., Lydersen C., Dahle S., Monshouwer M., Witkamp R.F. Congener specific PCB and polychlorinated camphene (toxaphene) levels in Svalbard ringed seals (Phoca hispida) in relation to sex, age, condition and cytochrome P450 enzyme activity. Sci. Total Environ. 1998, 216:1-11.
    • (1998) Sci. Total Environ. , vol.216 , pp. 1-11
    • Wolkers, J.1    Burkow, I.C.2    Lydersen, C.3    Dahle, S.4    Monshouwer, M.5    Witkamp, R.F.6
  • 63
    • 77649191643 scopus 로고    scopus 로고
    • Life history as a source of variation for persistent organic pollutant (POP) patterns in a community of common bottlenose dolphins (Tursiops truncatus) resident to Sarasota Bay, FL
    • Yordy J.E., Wells R.S., Balmer B.C., Schwacke L.H., Rowles T.K., Kucklick J.R. Life history as a source of variation for persistent organic pollutant (POP) patterns in a community of common bottlenose dolphins (Tursiops truncatus) resident to Sarasota Bay, FL. Sci. Total Environ. 2010, 408:2163-2172.
    • (2010) Sci. Total Environ. , vol.408 , pp. 2163-2172
    • Yordy, J.E.1    Wells, R.S.2    Balmer, B.C.3    Schwacke, L.H.4    Rowles, T.K.5    Kucklick, J.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.