Hepatic microsomal cytochrome P450 enzyme activity in relation to in vitro metabolism/inhibition of polychlorinated biphenyls and testosterone in Baltic grey seal (Halichoerus grypus)

Environmental Toxicology and Chemistry

Volumn 22, Issue 3, 2003, Pages 636-644

  Li, Hongxia ^a   Boon, Jan P ^b   Lewis, Wilma E ^b   Van Den Berg, Martin ^c   Nyman, Madeleine ^d   Letcher, Robert J ^a,b  

^a UNIVERSITY OF WINDSOR   (Canada)

^b ROYAL NETHERLANDS INSTITUTE FOR SEA RESEARCH   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d FINNISH FOREST RESEARCH INSTITUTE   (Finland)

Author keywords

Cytochrome P450 enzymes; In vitro metabolism inhibition Halichoerus grypus; Polychlorinated biphenyls; Testosterone

Indexed keywords

ENZYMES; METABOLISM; POLYCHLORINATED BIPHENYLS;

BIOACCUMULATION;

TOXICITY;

ANDROSTENEDIONE; CHLORAMPHENICOL; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 2B; CYTOCHROME P450 2C11; CYTOCHROME P450 3A; ELLIPTICINE; KETOCONAZOLE; LIVER ENZYME; OXYGENASE; POLYCHLORINATED BIPHENYL DERIVATIVE; TESTOSTERONE; TESTOSTERONE DERIVATIVE;

BIOACCUMULATION; BIOTRANSFORMATION; ENZYME ACTIVITY; PCB; PINNIPED; TOXICITY;

ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BIOTRANSFORMATION; CONCENTRATION RESPONSE; ENZYME ACTIVITY; EXPOSURE; FEMALE; LIVER MICROSOME; METABOLIC INHIBITION; NONHUMAN; PRIORITY JOURNAL; SEAL; STEREOCHEMISTRY; TOXICITY TESTING; TOXICOKINETICS;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; FEMALE; FINLAND; METABOLIC DETOXICATION, DRUG; MICROSOMES, LIVER; POLYCHLORINATED BIPHENYLS; SEALS, EARLESS; TESTOSTERONE; WATER POLLUTANTS, CHEMICAL;

ANIMALIA; GRYPUS; HALICHOERUS GRYPUS; MAMMALIA; PHOCIDAE; PINNIPEDIA; STAPHYLOCOCCUS PHAGE 3A; VERTEBRATA;

EID: 0242515904     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/1551-5028(2003)022<0636:HMCPEA>2.0.CO;2     Document Type: Article

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