Efficacy of D0870 treatment of experimental Candida vaginitis

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 7, 1997, Pages 1455-1459

  Fidel Jr , Paul L ^a   Cutright, Jessica L ^b   Sobel, Jack D ^b  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,4 DIFLUOROPHENYL) 1 [3 [2 [4 (2,2,3,3 TETRAFLUOROPROPOXY)PHENYL]VINYL] 1,2,4 TRIAZOL 1 YL] 3 (1,2,4 TRIAZOL 1 YL) 2 PROPANOL; FLUCONAZOLE;

ANIMAL MODEL; ANTIBIOTIC SENSITIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CANDIDA GLABRATA; DRUG EFFICACY; FEMALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; VAGINA CANDIDIASIS; VAGINITIS;

EID: 0343472052     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.7.1455     Document Type: Article

References (39)

1. Arilla, M. C., J. L. Carbonero, J. Schneider, P. Regulez, G. Quindos, J. Ponton, and R. Cisterna. 1992. Vulvovaginal candidiasis refractory to treatment with fluconazole. Eur. J. Obstet. Gynecol. Reprod. Biol. 44:77-80.
2. Bart-Delabesse, E., P. Boiron, A. Carlotti, and B. Dupont. 1993. Candida albicans genotyping in studies with patients with AIDS developing resistance to fluconazole. J. Clin. Microbiol. 31:2933-2937.
3. Case, C. P., A. P. MacGowan, N. M. Brown, D. S. Reeves, P. Whithead, and D. Felmingham. 1991. Prophylactic oral fluconazole and Candida fungaemia. Lancet 337:790. (Letter.)
4. Clemons, K. V., L. H. Hanson, and D. A. Stevens. 1993. Activities of the triazole D0870 in vitro and against murine blastomycosis. Antimicrob. Agents Chemother. 37:1177-1179.
5. Clemons, K. V., and D. A. Stevens. 1994. Utility of the triazole D0870 in the treatment of experimental systemic coccidioidomycosis. J. Med. Vet. Mycol. 32:323-326.
6. Clemons, K. V., and D. A. Stevens. 1995. Efficacy of the triazole D0870 in a murine model of systemic histoplasmosis. Antimicrob. Agents Chemother. 39:778-780.
7. Clift, R. A. 1984. Candidiasis in the transplant patient. Am. J. Med. 77(Suppl. 4D):34-38.
8. Correa, A. L., G. Velez, M. Albert, M. Luther, M. G. Rinaldi, and J. R. Graybill. 1995. Comparison of D0870 and fluconazole in the treatment of murine cryptococcal meningitis. J. Med. Vet. Mycol. 33:367-374.
9. Dunn, P. L., and R. J. North. 1991. Resolution of primary murine listeriosis and acquired resistance to lethal secondary infection can be mediated predominantly by Thy-1+ CD4-CD8-cells. J. Infect. Dis. 164:869-877.
10. Edwards, J. R., and S. McGregor. 1992. D0870, a new triazole antifungal agent: activity against Candida albicans in experimental and systemic infections in mice, abstr. 1047, p. 285. In Program and abstracts of the 32rd Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
11. Edwards, J. R., K. Nairn, G. M. Megson, G. L. Shepherd, and G. D. Hughes. 1993. Activity of D0870 against C. albicans and C. neoformans showing reduced susceptibility to fluconazole (FCZ), ahstr. 375, p. 188. In Program and abstracts of the 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
12. Fan-Havard, P., D. Capano, S. M. Smith, A. Mangia, and R. H. K. Eng. 1991. Development of resistance in Candida isolates from patients receiving prolonged antifungal therapy. Antimicrob. Agents Chemother. 35:2302-2305.
13. Fidel, P. L., Jr., M. E. Lynch, and J. D. Sobel. 1993. Candida-specific cell-mediated immunity is demonstrable in mice with experimental vaginal candidiasis. Infect. Immun. 61:1990-1995.
14. Fidel, P. L., Jr., J. L. Cutright, L. Tait, and J. D. Sobel. 1996. A murine model of Candida glabrata vaginitis. J. Infect. Dis. 173:425-431.
15. Fidel, P. L., Jr., M. E. Lynch, and J. D. Sobel. 1993. Candida-specific Th1-type responsiveness in mice with experimental vaginal candidiasis. Infect. Immun. 61:4202-4207.
16. Fleury, F. J. 1981. Adult vaginitis. Clin. Obstet. Gynecol. 24:407-438.
17. Geiger, A. M., B. Foxman, and J. D. Sobel. 1995. Chronic vulvovaginal candidiasis: characteristics of women with Candida albicans, Candida glabrata, and no Candida. Genitourin. Med. 71:304-307.
18. Graybill, J. R., L. K. Najvar, J. D. Holmberg, and M. F. Luther. 1995. Fluconazole, D0870, and flucytosine treatment of disseminated Candida tropicalis infections in mice. Antimicrob. Agents Chemother. 39:924-929.
19. Humphrey, M. J., S. Jevons, and M. H. Tarbit. 1985. Pharmacokinetic evaluation of UK-49,858, metabolically stable triazole antifungal drug, in animals and humans. Antimicrob. Agents Chemother. 28:648-653.
20. Karabinis, A., C. Hill, B. Leclercq, C. Tancrède, D. Baume, and A. Andremont. 1988. Risk factors for candidemia in cancer patients: a case-control study. J. Clin. Microbiol. 26:429-132.
21. Karyotakis, N. C., M. C. Dignani, R. Hachem, and E. J. Anaissie. 1995. Activities of D0870, a novel triazole, against Candida lusitaniae and Trichosporon beigelii in experimental murine infections. Antimicrob. Agents Chemother. 39:571-573.
22. Klein, R. S., C. A. Harris, C. B. Small et al. 1984. Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome. N. Engl. J. Med. 311:354-357.
23. Lynch, M. E., J. D. Sobel, and P. L. Fidel, Jr. 1996. Role of antifungal drug resistance in the pathogencsis of recurrent vulvovaginal candidasis. J. Med. Vet. Mycol. 34:337-339.
24. Macher, A. M. 1988. The pathology of AIDS. Public Health Rep. 103:246-250.
25. National Committee for Clinical Laboratory Standards. 1995. Reference method for broth dilution antifungal susceptibility testing for yeasts. Proposed standard M27-T. National Committee for Clinical Laboratory Standards, Villanova, Pa.
26. Odds, F. C. 1988. Candida and candidosis, p. 104-110. University Park Press, Baltimore, Md.
27. Pfaller, M. A., M. J. Bale, B. Buschelman, and P. Rhomberg. 1994. Antifungal activity of a new triazole, D0870, compared with four other antifungal agents tested against clinical isolates of Candida and Torulopsis glabrata. Diagn. Microbiol. Infect. Dis. 19:75-80.
28. Redondo-Lopez, V., M. Lynch, C. Schmitt, R. Cook, and J. D. Sobel. 1990. Torulopsis glabrata vaginitis: clinical aspects and susceptibility to antifungal agents. Obstet. Gynecol. 76:651-655.
29. Ruhnke, M., A. Eigler, E. Engelmann, B. Geiseler, and M. Trautmann. 1994. Correlation between antifungal susceptibility testing of Candida isolates from patients with HIV infection and clinical results after treatment with fluconazole. Infection 22:132-136.
30. Saag, M. S., and W. E. Dismukes. 1988. Azole antifungal agents: emphasis on new triazoles. Antimicrob. Agents Chemother. 32:1-8.
31. Sandven, P., A. Bjørneklett, A. Maeland, and the Norwegian Yeast Study Group. 1993. Susceptibility testing of Norwegian Candida albicans strains to fluconazole: emergence of resistance. Antimicrob. Agents Chemother. 37: 2443-2448.
32. Sangeorzan, J. A., S. F. Bradley, X. He, L. T. Zarins, G. L. Ridenour, R. N. Tiballi, and C. A. Kauffman. 1994. Epidemiology of oral candidiasis in HIV infected patients: colonization, infection, treatment, and emergence of fluconazole resistance. Am. J. Med. 97:339-346.
33. Sobel, J. D. 1982. Recurrent Candida vaginitis: a rational approach to therapy. Drug Therapy 12:41-55.
34. Sobel, J. D. 1985. Management of recurrent vulvovaginal candidiasis with intermittent ketoconazole prophylaxis. Obstet. Gynecol. 65:435-440.
35. Sobel, J. D. 1988. Pathogenesis and epidemiology of vulvovaginal candidiasis. Ann. N. Y. Acad. Sci. 544:547-557.
36. Sobel, J. D. 1990. Chemotherapy of fungal diseases, p. 365-383. In J. F. Ryley (ed.). Handbook of experimental pharmacology. Springer-Verlag, Berlin, Germany.
37. Sobel, J. D. Candida vaginitis. In W. Ledger and J. Witkin. (ed.), Vulvovaginal disease, in press. W. B. Saunders Co., New York, N.Y.
38. Sobel, J. D., and J. A. Vazquez. 1996. Symptomatic vulvovaginitis due to fluconazole-resistant Candida albicans in a female who was not infected with human immunodeficiency virus. Clin. Infect. Dis. 22:726-727.
39. Wardle, H. M., D. Law, C. B. Moore, C. Mason, and D. W. Denning. 1995. In vitro activity of D0870 compared with those of other azoles against fluconazole-resistant Candida spp. Antimicrob. Agents Chemother. 39:868-871.