The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties: Implication for S100A4 protein

Biochemical and Biophysical Research Communications

Volumn 413, Issue 2, 2011, Pages 325-329

  Bruyère, Emilie ^a,b   Jonckheere, Nicolas ^a,b   Frénois, Frédéric ^a,b   Mariette, Christophe ^a,b,c   Van Seuningen, Isabelle ^a,b  

^a JEAN PIERRE AUBERT RESEARCH CENTER   (France)

^b UNIV LILLE   (France)

^c LILLE UNIVERSITY HOSPITAL   (France)

Author keywords

Adenocarcinoma; Esophagus; MUC4; Mucin; S100A4

Indexed keywords

CALVASCULIN; MUCIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE MARKER; ESOPHAGUS CANCER; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR GROWTH; TUMOR VOLUME; TUMOR XENOGRAFT;

ADENOCARCINOMA; ANIMALS; CELL LINE, TUMOR; CELL MEMBRANE; CELL MOVEMENT; CELL PROLIFERATION; ESOPHAGEAL NEOPLASMS; HUMANS; MICE; MICE, SCID; MUCIN-4; NEOPLASM INVASIVENESS; RNA, SMALL INTERFERING; S100 PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS;

EID: 80053116316     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.08.095     Document Type: Article

References (32)

1. Carraway K.L., Ramsauer V.P., Haq B., Carothers Carraway C.A. Cell signaling through membrane mucins. BioEssays 2002, 25:66-71.
2. Jonckheere N., Van Seuningen I. The ever growing family of membrane-bound mucins. The Epithelial Mucins: Structure/Function. Roles in Cancer and Inflammatory Diseases 2008, 17-38. Research Signpost, Kerala, India. I. Van Seuningen (Ed.).
3. Jonckheere N., Van Seuningen I. The membrane-bound mucins: from cell signalling to transcriptional regulation and expression in epithelial cancers. Biochimie 2010, 92:1-11.
4. Kufe D.W. Mucins in cancer: function, prognosis and therapy. Nat. Rev. Cancer 2009, 9:874-885.
5. Hollingsworth M.A., Swanson B.J. Mucins in cancer: protection and control of the cell surface. Nat. Rev. Cancer 2004, 4:45-60.
6. Chaturvedi P., Singh A.P., Batra S.K. Structure, evolution, and biology of the MUC4 mucin. FASEB J. 2008, 22:966-981.
7. Jonckheere N., Van Seuningen I. The membrane-bound mucins: how large O-glycoproteins play key roles in epithelial cancers and hold promise as biological tools for gene-based and immunotherapies. Crit. Rev. Oncog. 2008, 14:177-196.
8. Arul G.S., Moorghen M., Myerscough N., Alderson D.A., Spicer R.D., Corfield A.P. Mucin gene expression in Barrett's oesophagus: an in situ hybridisation and immunohistochemical study. Gut 2000, 47:753-761.
9. Guillem P., Billeret V., Buisine M.P., Flejou J.F., Lecomte-Houcke M., Degand P., Aubert J.P., Triboulet J.P., Porchet N. Mucin gene expression and cell differentiation in human normal, premalignant and malignant esophagus. Int. J. Cancer 2000, 88:856-861.
10. Holmes R.S., Vaughan T.L. Epidemiology and pathogenesis of esophageal cancer. Semin. Radiat. Oncol. 2007, 17:2-9.
11. Mariette C., Piessen G., Briez N., Gronnier C., Triboulet J.P. Oesophagogastric junction adenocarcinoma: which therapeutic approach?. Lancet Oncol. 2011, 12:296-305.
12. Kauer W.K., Peters J.H., DeMeester T.R., Feussner H., Ireland A.P., Stein H.J., Siewert R.J. Composition and concentration of bile acid reflux into the esophagus of patients with gastroesophageal reflux disease. Surgery 1997, 122:874-881.
13. Wild C.P., Hardie L.J. Reflux, Barrett's oesophagus and adenocarcinoma: burning questions. Nat. Rev. Cancer 2003, 3:676-684.
14. Fein M., Maroske J., Fuchs K.H. Importance of duodenogastric reflux in gastro-oesophageal reflux disease. Br. J. Surg. 2006, 93:1475-1482.
15. Colleypriest B.J., Ward S.G., Tosh D. How does inflammation cause Barrett's metaplasia?. Curr. Opin. Pharmacol. 2009, 9:721-726.
16. Prach A.T., MacDonald T.A., Hopwood D.A., Johnston D.A. Increasing incidence of Barrett's oesophagus: education, enthusiasm, or epidemiology?. Lancet 1997, 350:933.
17. Mariette C., Perrais M., Leteurtre E., Jonckheere N., Hemon B., Pigny P., Batra S., Aubert J.P., Triboulet J.P., Van Seuningen I. Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway. Biochem. J. 2004, 377:701-708.
18. Piessen G., Jonckheere N., Vincent A., Hemon B., Ducourouble M.P., Copin M.C., Mariette C., Van Seuningen I. Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1alpha. Biochem. J. 2007, 402:81-91.
19. Singh A.P., Senapati S., Ponnusamy M.P., Jain M., Lele S.M., Davis J.S., Remmenga S., Batra S.K. Clinical potential of mucins in diagnosis, prognosis, and therapy of ovarian cancer. Lancet Oncol. 2008, 9:1076-1085.
20. Gilman A.G., Simon M.I., Bourne H.R., Harris B.A., Long R., Ross E.M., Stull J.T., Taussig R., Arkin A.P., Cobb M.H., Cyster J.G., Devreotes P.N., Ferrell J.E., Fruman D., Gold M., Weiss A., Berridge M.J., Cantley L.C., Catterall W.A., Coughlin S.R., Olson E.N., Smith T.F., Brugge J.S., Botstein D., Dixon J.E., Hunter T., Lefkowitz R.J., Pawson A.J., Sternberg P.W., Varmus H., Subramaniam S., Sinkovits R.S., Li J., Mock D., Ning Y., Saunders B., Sternweis P.C., Hilgemann D., Scheuermann R.H., DeCamp D., Hsueh R., Lin K.M., Ni Y., Seaman W.E., Simpson P.C., O'Connell T.D., Roach T., Choi S., Eversole-Cire P., Fraser I., Mumby M.C., Zhao Y., Brekken D., Shu H., Meyer T., Chandy G., Heo W.D., Liou J., O'Rourke N., Verghese M., Mumby S.M., Han H., Brown H.A., Forrester J.S., Ivanova P., Milne S.B., Casey P.J., Harden T.K., Doyle J., Gray M.L., Michnick S., Schmidt M.A., Toner M., Tsien R.Y., Natarajan M., Ranganathan R., Sambrano G.R. Overview of the alliance for cellular signaling. Nature 2002, 420:703-706.
21. van der Sluis M., Melis M.H., Jonckheere N., Ducourouble M.P., Buller H.A., Renes I., Einerhand A.W., Van Seuningen I. The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells. Biochem. Biophys. Res. Commun. 2004, 325:952-960.
22. Jonckheere N., Perrais M., Mariette C., Batra S.K., Aubert J.P., Pigny P., Van Seuningen I. A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-beta in pancreatic carcinogenesis. Oncogene 2004, 23:5729-5738.
23. Fauquette V., Perrais M., Cerulis S., Jonckheere N., Ducourouble M.P., Aubert J.P., Pigny P., Van Seuningen I. The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells. Biochem. J. 2005, 386:35-45.
24. Chaturvedi P., Singh A.P., Moniaux N., Senapati S., Chakraborty S., Meza J.L., Batra S.K. MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins. Mol. Cancer Res.: MCR 2007, 5:309-320.
25. Ponnusamy M.P., Lakshmanan I., Jain M., Das S., Chakraborty S., Dey P., Batra S.K. MUC4 mucin-induced epithelial to mesenchymal transition: a novel mechanism for metastasis of human ovarian cancer cells. Oncogene 2010, 29:5741-5754.
26. Piessen G., Wacrenier A., Briez N., Triboulet J.P., Van Seuningen I., Mariette C. Clinical impact of MUC1 and MUC4 expression in Barrett-associated oesophageal adenocarcinoma. J. Clin. Pathol. 2009, 62:1144-1146.
27. Sherbet G.V., Lakshmi M.S. S100A4 (MTS1) calcium binding protein in cancer growth, invasion and metastasis. Anticancer Res. 1998, 18:2415-2421.
28. Li Z.H., Bresnick A.R. The S100A4 metastasis factor regulates cellular motility via a direct interaction with myosin-IIA. Cancer Res. 2006, 66:5173-5180.
29. Sherbet G.V. Metastasis promoter S100A4 is a potentially valuable molecular target for cancer therapy. Cancer Lett. 2009, 280:15-30.
30. H.Y. Zhang, X.Z. Zheng, X.H. Wang, X.Y. Xuan, F. Wang, S.S. Li, S100A4 mediated cell invasion and metastasis of esophageal squamous cell carcinoma via the regulation of MMP-2 and E-cadherin activity, Mol. Biol. Rep. (2011).
31. Lee O.J., Hong S.M., Razvi M.H., Peng D., Powell S.M., Smoklin M., Moskaluk C.A., El-Rifai W. Expression of calcium-binding proteins S100A2 and S100A4 in Barrett's adenocarcinomas. Neoplasia 2006, 8:843-850.
32. Tabata T., Tsukamoto N., Fooladi A.A., Yamanaka S., Furukawa T., Ishida M., Sato D., Gu Z., Nagase H., Egawa S., Sunamura M., Horii A. RNA interference targeting against S100A4 suppresses cell growth and motility and induces apoptosis in human pancreatic cancer cells. Biochem. Biophys. Res. Commun. 2009, 390:475-480.