Biotransformation of (-) -camphor by salmonella typhimurium oy1002/2a6 expressing human cyp2a6 and nadph-p450 reductase

Journal of Oleo Science

Volumn 60, Issue 10, 2011, Pages 545-548

  Nakahashi, Hiroshi ^a   Miyazawa, Mitsuo ^a  

^a KINKI UNIVERSITY   (Japan)

Author keywords

( ) camphor; (1s; 5s) ( ) 5 exo hydroxycamphor; 7s) ( ) 8 hydroxycamphor; Cyp2a; Salmonella typhimurium oy1002 2a6

Indexed keywords

(-) -CAMPHOR; (1S; 5S) - (-) -5-EXO-HYDROXYCAMPHOR; 7S) - (-) -8-HYDROXYCAMPHOR; CYP2A; SALMONELLA TYPHIMURIUM OY1002/2A6;

BIOCONVERSION; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITES;

SALMONELLA;

CAMPHOR; COUMARIN 7 HYDROXYLASE; COUMARIN 7-HYDROXYLASE; RECOMBINANT PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; UNSPECIFIC MONOOXYGENASE;

ARTICLE; BIOCATALYSIS; BIOTRANSFORMATION; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; SALMONELLA TYPHIMURIUM;

ARYL HYDROCARBON HYDROXYLASES; BIOCATALYSIS; BIOTRANSFORMATION; CAMPHOR; HUMANS; MOLECULAR STRUCTURE; NADPH-FERRIHEMOPROTEIN REDUCTASE; RECOMBINANT PROTEINS; SALMONELLA TYPHIMURIUM;

EID: 80053072485     PISSN: 13458957     EISSN: 13473352     Source Type: Journal    
DOI: 10.5650/jos.60.545     Document Type: Article

References (14)

1. Karimia, G.; Iranshahi, M.; Hosseinalizadeh, F.; Riahi, B.; Sahebkar, A. Screening of acetylcholinesterase in-hibitory activity of terpenoid and coumarin derivatives from the genus Ferula. Pharmacologyonline 1, 566-57 (2010).
2. Yu, Q.; Bi, J. X.; Yan, Z.; Yun, Z.; Gang, F.; Xiao, L. Y.; Sin, Y. P. Characterization of aroma active compounds in fruit juice and peel oil of jinchen sweet orange fruit (Citrus sinensi (L.) Osbeck) by GC-MS and GC-O. Molecules 13, 1333-134 (2008).
3. Miyazawa, M.; Shindo, M.; Shimada, T. Biotransforma-tion o (-) -verbenone by human liver microsomes. Biosci. Biotechnol. Biochem. 66, 2458-246 (2002).
4. Miyazawa, M.; Gyoubu, K. Metabolism o (+) -fenchone by CYP2A6 and CYP2B6 in human liver microsomes. Biol. Pharm. Bull. 29, 2354-235 (2006).
5. Miyazawa, M.; Gyoubu, K. Metabolism o (-) -fenchone by CYP2A6 and CYP2B6 in human liver microsomes. Xenobiotica 37, 194-20 (2007).
6. Gyoubu, K.; Miyazawa, M. In vitro metabolism o (-) -camphor using human liver microsomes and CYP2A6. Biol. Pharm. Bull. 30, 230-23 (2007).
7. Miyazawa, M.; Marumoto, S.; Takahashi, T.; Nakahashi, H.; Haigou, R.; Nakanishi K. Metabolism o (+) - an (-) -menthols by CYP2A6 in human liver microsomes. J. Oleo Sci. 60, 127-13 (2011).
8. Tucker, A. O.; Maciarello, M. J. Essential oils of culti-vars of Dalmatian sag (Salvia officinalis L.). J. Es-sential Oil Res. 2, 139-14 (1990).
9. Xing, Z.; Min, Y.; Rui, L.; Jun, Y.; De, A. G. Microbial transformation of curcumin by Rhizopus chinensis. Biocatalysis Biotoransformation 28, 380-38 (2003).
10. Aryal, P.; Yoshikawa, K.; Terashita, T.; Guengerich, F. P.; Shimada, T.; Oda, Y. Development of a new genotoxici-ty test system with Salmonella typhimurium OY1001/1A2 expressing human CYP1A2 and NADPH-P450 reductase. Mutation Res. 442, 113-120 (1999).
11. Aryal, P.; Terashita, T.; Shimada, T.; Oda, Y. Use of ge-netically engineered Salmonella typhimurium OY1002/1A2 strain coexpressing human cytochrome P450 1A2 and NADPH-cytochrome P450 reductase and bacterial O-acetyltransferase in SOS/umu assay. Environmental Mol. Mutagenesis 36, 121-126 (2000).
12. Oda, Y.; Aryal, P.; Terashita, T. Elizabeth, M. J. Gueng-erich, F. P.; Shimada, T. Metabolic activation of hetero-cyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferase. Mutation Res. 492, 81-9 (2001).
13. Miyazawa, M.; Miyamoto, Y. Biotransformation o (1R) - (+) - and (1S) (-) -camphor by the larvae of common cutworm (Spodoptera litura). J. Mol. Catalysis B: Enzymatic 27, 83-8 (2004).
14. Yasuda, K.; Ikushiro, S.; Kamakura, M.; Ohta, M.; Sakaki, T. Metabolism of sesamin by cytochrome P450 in human liver microsomes. Drug metabolism Dispo-sition 3 (12), 2117-212 (2010).