메뉴 건너뛰기




Volumn 5, Issue 5, 2011, Pages 227-240

The facts behind niacin

Author keywords

cardiovascular risk; cholesterol; lipid lowering therapy; niacin

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ACETYLSALICYLIC ACID; AGENTS AFFECTING LIPID METABOLISM; BILE ACID SEQUESTRANT; CHOLESTEROL ESTER TRANSFER PROTEIN; CHOLESTEROL ESTER TRANSFER PROTEIN INHIBITOR; CLOFIBRATE; COLESTIPOL; EZETIMIBE; FIBRIC ACID DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LAROPIPRANT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; NICOTINIC ACID; PLACEBO; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 INHIBITOR; SIMVASTATIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 80053065826     PISSN: 17539447     EISSN: 17539455     Source Type: Journal    
DOI: 10.1177/1753944711419197     Document Type: Review
Times cited : (26)

References (62)
  • 1
    • 79952446880 scopus 로고    scopus 로고
    • The role of niacin in raising high-density lipoprotein cholesterol to reduce cardiovascular events in patients with atherosclerotic cardiovascular disease and optimally treated low-density lipoprotein cholesterol: baseline characteristics of study participants. The Atherothrombosis Intervention in Metabolic Syndrome with low HDL / high triglycerides: impact on Global Health outcomes (AIM-HIGH) Trial
    • Aim-High Investigators
    • Aim-High Investigators. (2011) The role of niacin in raising high-density lipoprotein cholesterol to reduce cardiovascular events in patients with atherosclerotic cardiovascular disease and optimally treated low-density lipoprotein cholesterol: baseline characteristics of study participants. The Atherothrombosis Intervention in Metabolic Syndrome with low HDL / high triglycerides: impact on Global Health outcomes (AIM-HIGH) Trial. Am Heart J 161: 538–543.
    • (2011) Am Heart J , vol.161 , pp. 538-543
  • 2
  • 3
    • 0000808276 scopus 로고
    • Influence of nicotinic acid on serum cholesterol in man
    • Altschul R. Hoffer A. Stephen J.D. (1955) Influence of nicotinic acid on serum cholesterol in man. Arch Biochem Biophys 54: 558–559.
    • (1955) Arch Biochem Biophys , vol.54 , pp. 558-559
    • Altschul, R.1    Hoffer, A.2    Stephen, J.D.3
  • 4
    • 78449267756 scopus 로고    scopus 로고
    • Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: a double-blind randomised trial
    • Armitage J. Bowman L. Wallendszus K. Bulbulia R. Rahimi K. Haynes R. et al (2010) Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: a double-blind randomised trial. Lancet 376: 1658–1669.
    • (2010) Lancet , vol.376 , pp. 1658-1669
    • Armitage, J.1    Bowman, L.2    Wallendszus, K.3    Bulbulia, R.4    Rahimi, K.5    Haynes, R.6
  • 5
    • 78449281377 scopus 로고    scopus 로고
    • Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials
    • Baigent C. Blackwell L. Emberson J. Holland L.E. Reith C. Bhala N. et al (2010) Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 376: 1670–1681.
    • (2010) Lancet , vol.376 , pp. 1670-1681
    • Baigent, C.1    Blackwell, L.2    Emberson, J.3    Holland, L.E.4    Reith, C.5    Bhala, N.6
  • 6
    • 84948007950 scopus 로고
    • beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts
    • Blankenhorn D.H. Nessim S.A. Johnson R.L. Sanmarco M.E. Azen S.P. Cashin-Hemphill L. (1987) beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts. JAMA 257: 3233–3240.
    • (1987) JAMA , vol.257 , pp. 3233-3240
    • Blankenhorn, D.H.1    Nessim, S.A.2    Johnson, R.L.3    Sanmarco, M.E.4    Azen, S.P.5    Cashin-Hemphill, L.6
  • 7
    • 33748996495 scopus 로고    scopus 로고
    • Niaspan in the management of dyslipidaemia: the evidence
    • Brown B.G. (2006) Niaspan in the management of dyslipidaemia: the evidence. Eur Heart J Suppl 8: F60–F67.
    • (2006) Eur Heart J Suppl , vol.8 , pp. F60-F67
    • Brown, B.G.1
  • 8
    • 0032568085 scopus 로고    scopus 로고
    • Use of niacin, statins, and resins in patients with combined hyperlipidemia
    • Brown B.G. Zambon A. Poulin D. Rocha A. Maher V.M. Davis J.W. et al (1998) Use of niacin, statins, and resins in patients with combined hyperlipidemia. Am J Cardiol 81: 52B–59B.
    • (1998) Am J Cardiol , vol.81 , pp. 52B-59B
    • Brown, B.G.1    Zambon, A.2    Poulin, D.3    Rocha, A.4    Maher, V.M.5    Davis, J.W.6
  • 9
    • 0035969564 scopus 로고    scopus 로고
    • Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease
    • Brown B.G. Zhao X.Q. Chait A. Fisher L.D. Cheung M.C. Morse J.S. et al (2001) Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 345: 1583–1592.
    • (2001) N Engl J Med , vol.345 , pp. 1583-1592
    • Brown, B.G.1    Zhao, X.Q.2    Chait, A.3    Fisher, L.D.4    Cheung, M.C.5    Morse, J.S.6
  • 10
    • 0025183769 scopus 로고
    • Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B
    • Brown G. Albers J.J. Fisher L.D. Schaefer S.M. Lin J.T. Kaplan C. et al (1990) Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B. N Engl J Med 323: 1289–1298.
    • (1990) N Engl J Med , vol.323 , pp. 1289-1298
    • Brown, G.1    Albers, J.J.2    Fisher, L.D.3    Schaefer, S.M.4    Lin, J.T.5    Kaplan, C.6
  • 12
    • 11144355354 scopus 로고    scopus 로고
    • Intensive versus moderate lipid lowering with statins after acute coronary syndromes
    • Cannon C.P. Braunwald E. McCabe C.H. Rader D.J. Rouleau J.L. Belder R. et al (2004) Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med 350: 1495–1504.
    • (2004) N Engl J Med , vol.350 , pp. 1495-1504
    • Cannon, C.P.1    Braunwald, E.2    McCabe, C.H.3    Rader, D.J.4    Rouleau, J.L.5    Belder, R.6
  • 13
    • 0032542302 scopus 로고    scopus 로고
    • Efficacy and safety of an extended-release niacin (niaspan): a long-term study
    • discussion 85U–86U
    • Capuzzi D.M. Guyton J.R. Morgan J.M. Goldberg A.C. Kreisberg R.A. Brusco O.A. et al (1998) Efficacy and safety of an extended-release niacin (niaspan): a long-term study. Am J Cardiol 82: 74U–81U, discussion 85U–86U.
    • (1998) Am J Cardiol , vol.82 , pp. 74U-81U
    • Capuzzi, D.M.1    Guyton, J.R.2    Morgan, J.M.3    Goldberg, A.C.4    Kreisberg, R.A.5    Brusco, O.A.6
  • 14
    • 0024466520 scopus 로고
    • pronounced lowering of serum levels of lipoprotein Lp(a) in hyperlipidaemic subjects treated with nicotinic acid
    • Carlson L.A. Hamsten A. Asplund A. (1989) pronounced lowering of serum levels of lipoprotein Lp(a) in hyperlipidaemic subjects treated with nicotinic acid. J Intern Med 226: 271–276.
    • (1989) J Intern Med , vol.226 , pp. 271-276
    • Carlson, L.A.1    Hamsten, A.2    Asplund, A.3
  • 15
    • 0023910325 scopus 로고
    • Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid
    • Carlson L.A. Rosenhamer G. (1988) Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid. Acta Med Scand 223: 405–418.
    • (1988) Acta Med Scand , vol.223 , pp. 405-418
    • Carlson, L.A.1    Rosenhamer, G.2
  • 17
    • 0016630250 scopus 로고
    • Clofibrate and niacin in coronary heart disease
    • Coronary Drug Project Research Group
    • Coronary Drug Project Research Group. (1975) Clofibrate and niacin in coronary heart disease. JAMA 231: 360–381.
    • (1975) JAMA , vol.231 , pp. 360-381
  • 18
    • 78649717560 scopus 로고    scopus 로고
    • Does carotid intima-media thickness regression predict reduction of cardiovascular events? A meta-analysis of 41 randomized trials
    • Costanzo P. Perrone-Filardi P. Vassallo E. Paolillo S. Cesarano P. Brevetti G. et al (2010) Does carotid intima-media thickness regression predict reduction of cardiovascular events? A meta-analysis of 41 randomized trials. J Am Coll Cardiol 56: 2006–2020.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 2006-2020
    • Costanzo, P.1    Perrone-Filardi, P.2    Vassallo, E.3    Paolillo, S.4    Cesarano, P.5    Brevetti, G.6
  • 19
    • 0032572086 scopus 로고    scopus 로고
    • Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TEXCAPS. Air Force / Texas Coronary Atherosclerosis Prevention Study
    • Downs J.R. Clearfield M. Weis S. Whitney E. Shapiro D.R. Beere P.A. et al (1998) Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TEXCAPS. Air Force / Texas Coronary Atherosclerosis Prevention Study. JAMA 279: 1615–1622.
    • (1998) JAMA , vol.279 , pp. 1615-1622
    • Downs, J.R.1    Clearfield, M.2    Weis, S.3    Whitney, E.4    Shapiro, D.R.5    Beere, P.A.6
  • 20
    • 78651350647 scopus 로고    scopus 로고
    • PCSK9: An emerging target for treatment of hypercholesterolemia
    • Duff C.J. Hooper N.M. (2011) PCSK9: An emerging target for treatment of hypercholesterolemia. Expert Opin Ther Targets 15: 157–168.
    • (2011) Expert Opin Ther Targets , vol.15 , pp. 157-168
    • Duff, C.J.1    Hooper, N.M.2
  • 21
    • 16644369497 scopus 로고    scopus 로고
    • Niacin noncompetitively inhibits DGAT 2 but not DGAT 1 activity in Hepg 2 cells
    • Ganji S.H. Tavintharan S. Zhu D. Xing Y. Kamanna V.S. Kashyap M.L. (2004) Niacin noncompetitively inhibits DGAT 2 but not DGAT 1 activity in Hepg 2 cells. J Lipid Res 45: 1835–1845.
    • (2004) J Lipid Res , vol.45 , pp. 1835-1845
    • Ganji, S.H.1    Tavintharan, S.2    Zhu, D.3    Xing, Y.4    Kamanna, V.S.5    Kashyap, M.L.6
  • 22
    • 70350360003 scopus 로고    scopus 로고
    • 2009 Canadian Cardiovascular Society / Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendations
    • Genest J. McPherson R. Frohlich J. Anderson T. Campbell N. Carpentier A. et al (2009) 2009 Canadian Cardiovascular Society / Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendations. Can J Cardiol 25: 567–579.
    • (2009) Can J Cardiol , vol.25 , pp. 567-579
    • Genest, J.1    McPherson, R.2    Frohlich, J.3    Anderson, T.4    Campbell, N.5    Carpentier, A.6
  • 23
    • 0029149881 scopus 로고
    • The prevalence of side effects with regular and sustained-release nicotinic acid
    • Gibbons L.W. Gonzalez V. Gordon N. Grundy S. (1995) The prevalence of side effects with regular and sustained-release nicotinic acid. Am J Med 99: 378–385.
    • (1995) Am J Med , vol.99 , pp. 378-385
    • Gibbons, L.W.1    Gonzalez, V.2    Gordon, N.3    Grundy, S.4
  • 24
    • 35148892823 scopus 로고    scopus 로고
    • European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts)
    • Graham I. Atar D. Borch-Johnsen K. Boysen G. Burell G. Cifkova R. et al (2007) European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur Heart J 28: 2375–2414.
    • (2007) Eur Heart J , vol.28 , pp. 2375-2414
    • Graham, I.1    Atar, D.2    Borch-Johnsen, K.3    Boysen, G.4    Burell, G.5    Cifkova, R.6
  • 25
    • 0019474574 scopus 로고
    • Influence of nicotinic acid on metabolism of cholesterol and triglycerides in man
    • Grundy S.M. Mok H.Y. Zech L. Berman M. (1981) Influence of nicotinic acid on metabolism of cholesterol and triglycerides in man. J Lipid Res 22: 24–36.
    • (1981) J Lipid Res , vol.22 , pp. 24-36
    • Grundy, S.M.1    Mok, H.Y.2    Zech, L.3    Berman, M.4
  • 26
    • 0037158150 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes: results of the Assessment of Diabetes Control and Evaluation of the Efficacy of Niaspan Trial
    • Grundy S.M. Vega G.L. McGovern M.E. Tulloch B.R. Kendall D.M. Fitz-Patrick D. et al (2002) Efficacy, safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes: results of the Assessment of Diabetes Control and Evaluation of the Efficacy of Niaspan Trial. Arch Intern Med 162: 1568–1576.
    • (2002) Arch Intern Med , vol.162 , pp. 1568-1576
    • Grundy, S.M.1    Vega, G.L.2    McGovern, M.E.3    Tulloch, B.R.4    Kendall, D.M.5    Fitz-Patrick, D.6
  • 27
    • 33947118734 scopus 로고    scopus 로고
    • Safety considerations with niacin therapy
    • Guyton J.R. Bays H.E. (2007) Safety considerations with niacin therapy. Am J Cardiol 99: 22C–31C.
    • (2007) Am J Cardiol , vol.99 , pp. 22C-31C
    • Guyton, J.R.1    Bays, H.E.2
  • 28
    • 0034708959 scopus 로고    scopus 로고
    • Extended-release niacin vs gemfibrozil for the treatment of low levels of high-density lipoprotein cholesterol. Niaspan-Gemfibrozil Study Group
    • Guyton J.R. Blazing M.A. Hagar J. Kashyap M.L. Knopp R.H. Mckenney J.M. et al (2000) Extended-release niacin vs gemfibrozil for the treatment of low levels of high-density lipoprotein cholesterol. Niaspan-Gemfibrozil Study Group. Arch Intern Med 160: 1177–1184.
    • (2000) Arch Intern Med , vol.160 , pp. 1177-1184
    • Guyton, J.R.1    Blazing, M.A.2    Hagar, J.3    Kashyap, M.L.4    Knopp, R.H.5    Mckenney, J.M.6
  • 29
    • 0032530770 scopus 로고    scopus 로고
    • Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia
    • Guyton J.R. Goldberg A.C. Kreisberg R.A. Sprecher D.L. Superko H.R. O'Connor C.M. (1998) Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia. Am J Cardiol 82: 737–743.
    • (1998) Am J Cardiol , vol.82 , pp. 737-743
    • Guyton, J.R.1    Goldberg, A.C.2    Kreisberg, R.A.3    Sprecher, D.L.4    Superko, H.R.5    O'Connor, C.M.6
  • 30
    • 0037031061 scopus 로고    scopus 로고
    • MRC / BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial
    • Heart Protection Study Collaborative Group
    • Heart Protection Study Collaborative Group. (2002) MRC / BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360: 7–22.
    • (2002) Lancet , vol.360 , pp. 7-22
  • 31
    • 78049262204 scopus 로고    scopus 로고
    • Critical appraisal of laropiprant and extended-release niacin combination in the management of mixed dyslipidemias and primary hypercholesterolemia
    • Hussein A.A. Nicholls S.J. (2010) Critical appraisal of laropiprant and extended-release niacin combination in the management of mixed dyslipidemias and primary hypercholesterolemia. Ther Clin Risk Manag 6: 183–190.
    • (2010) Ther Clin Risk Manag , vol.6 , pp. 183-190
    • Hussein, A.A.1    Nicholls, S.J.2
  • 32
    • 0027963479 scopus 로고
    • Comparative effects of lovastatin and niacin in primary hypercholesterolemia. A prospective trial
    • Illingworth D.R. Stein E.A. Mitchel Y.B. Dujovne C.A. Frost P.H. Knopp R.H. et al (1994) Comparative effects of lovastatin and niacin in primary hypercholesterolemia. A prospective trial. Arch Intern Med 154: 1586–1595.
    • (1994) Arch Intern Med , vol.154 , pp. 1586-1595
    • Illingworth, D.R.1    Stein, E.A.2    Mitchel, Y.B.3    Dujovne, C.A.4    Frost, P.H.5    Knopp, R.H.6
  • 33
    • 0031442321 scopus 로고    scopus 로고
    • Niacin decreases removal of high-density lipoprotein apolipoprotein A-I but not cholesterol ester by Hep G 2 cells. Implication for reverse cholesterol transport
    • Jin F.Y. Kamanna V.S. Kashyap M.L. (1997) Niacin decreases removal of high-density lipoprotein apolipoprotein A-I but not cholesterol ester by Hep G 2 cells. Implication for reverse cholesterol transport. Arterioscler Thromb Vasc Biol 17: 2020–2028.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 2020-2028
    • Jin, F.Y.1    Kamanna, V.S.2    Kashyap, M.L.3
  • 34
    • 0033549840 scopus 로고    scopus 로고
    • Drug treatment of lipid disorders
    • Knopp R.H. (1999) Drug treatment of lipid disorders. N Engl J Med 341: 498–511.
    • (1999) N Engl J Med , vol.341 , pp. 498-511
    • Knopp, R.H.1
  • 35
    • 70350516769 scopus 로고    scopus 로고
    • Effects of high-dose modified-release nicotinic acid on atherosclerosis and vascular function: a randomized, placebo-controlled, magnetic resonance imaging study
    • Lee J.M. Robson M.D. Yu L.M. Shirodaria C.C. Cunnington C. Kylintireas I. et al (2009) Effects of high-dose modified-release nicotinic acid on atherosclerosis and vascular function: a randomized, placebo-controlled, magnetic resonance imaging study. J Am Coll Cardiol 54: 1787–1794.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 1787-1794
    • Lee, J.M.1    Robson, M.D.2    Yu, L.M.3    Shirodaria, C.C.4    Cunnington, C.5    Kylintireas, I.6
  • 36
    • 36549034768 scopus 로고    scopus 로고
    • blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths
    • Lewington S. Whitlock G. Clarke R. Sherliker P. Emberson J. Halsey J. et al (2007) blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet 370: 1829–1839.
    • (2007) Lancet , vol.370 , pp. 1829-1839
    • Lewington, S.1    Whitlock, G.2    Clarke, R.3    Sherliker, P.4    Emberson, J.5    Halsey, J.6
  • 37
    • 84912806724 scopus 로고
    • Lipid Research Clinics Program
    • Lipid Research Clinics Program
    • Lipid Research Clinics Program. (1984) Lipid Research Clinics Program. JAMA 252: 2545–2548.
    • (1984) JAMA , vol.252 , pp. 2545-2548
  • 38
    • 0032487931 scopus 로고    scopus 로고
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
    • Lipid Study Group
    • Lipid Study Group. (1998) Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. N Engl J Med 339: 1349–1357.
    • (1998) N Engl J Med , vol.339 , pp. 1349-1357
  • 39
    • 0023733072 scopus 로고
    • Effect of low-dose niacin on high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol ratio
    • Luria M.H. (1988) Effect of low-dose niacin on high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol ratio. Arch Intern Med 148: 2493–2495.
    • (1988) Arch Intern Med , vol.148 , pp. 2493-2495
    • Luria, M.H.1
  • 40
    • 53149118030 scopus 로고    scopus 로고
    • Lipid-modifying efficacy and tolerability of extended-release niacin / laropiprant in patients with primary hypercholesterolaemia or mixed dyslipidaemia
    • Maccubbin D. Bays H.E. Olsson A.G. Elinoff V. Elis A. Mitchel Y. et al (2008) Lipid-modifying efficacy and tolerability of extended-release niacin / laropiprant in patients with primary hypercholesterolaemia or mixed dyslipidaemia. Int J Clin Pract 62: 1959–1970.
    • (2008) Int J Clin Pract , vol.62 , pp. 1959-1970
    • Maccubbin, D.1    Bays, H.E.2    Olsson, A.G.3    Elinoff, V.4    Elis, A.5    Mitchel, Y.6
  • 41
    • 67649372666 scopus 로고    scopus 로고
    • Flushing profile of extended-release niacin / laropiprant versus gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease
    • Maccubbin D. Koren M.J. Davidson M. Gavish D. Pasternak R.C. Macdonell G. et al (2009) Flushing profile of extended-release niacin / laropiprant versus gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease. Am J Cardiol 104: 74–81.
    • (2009) Am J Cardiol , vol.104 , pp. 74-81
    • Maccubbin, D.1    Koren, M.J.2    Davidson, M.3    Gavish, D.4    Pasternak, R.C.5    Macdonell, G.6
  • 42
    • 0037413638 scopus 로고    scopus 로고
    • Ectopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis
    • Martinez L.O. Jacquet S. Esteve J.P. Rolland C. Cabezon E. Champagne E. et al (2003) Ectopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis. Nature 421: 75–79.
    • (2003) Nature , vol.421 , pp. 75-79
    • Martinez, L.O.1    Jacquet, S.2    Esteve, J.P.3    Rolland, C.4    Cabezon, E.5    Champagne, E.6
  • 43
    • 78651398058 scopus 로고    scopus 로고
    • CETP inhibition shows promise as way to reduce cardiovascular disease risk
    • Mitka M. (2011) CETP inhibition shows promise as way to reduce cardiovascular disease risk. JAMA 305: 136–137.
    • (2011) JAMA , vol.305 , pp. 136-137
    • Mitka, M.1
  • 44
    • 77949546541 scopus 로고    scopus 로고
    • High-density lipoprotein and coronary heart disease: current and future therapies
    • Natarajan P. Ray K.K. Cannon C.P. (2010) High-density lipoprotein and coronary heart disease: current and future therapies. J Am Coll Cardiol 55: 1283–1299.
    • (2010) J Am Coll Cardiol , vol.55 , pp. 1283-1299
    • Natarajan, P.1    Ray, K.K.2    Cannon, C.P.3
  • 45
    • 0035897696 scopus 로고    scopus 로고
    • Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • National Cholesterol Education Program
    • National Cholesterol Education Program. (2001) Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285: 2486–2497.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 46
    • 84857227980 scopus 로고    scopus 로고
    • National Heart Lung and Blood Institute
    • Accessed May 27, 2011
    • National Heart Lung and Blood Institute (2011) http://public.nhlbi.nih.gov/newsroom/home/GetPressRelease.aspx?id=2792. Accessed May 27, 2011.
    • (2011)
  • 47
    • 0033531215 scopus 로고    scopus 로고
    • carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group
    • O'Leary D.H. Polak J.F. Kronmal R.A. Manolio T.A. Burke G.L. Wolfson S.K. Jr (1999) carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 340: 14–22.
    • (1999) N Engl J Med , vol.340 , pp. 14-22
    • O'Leary, D.H.1    Polak, J.F.2    Kronmal, R.A.3    Manolio, T.A.4    Burke, G.L.5    Wolfson, S.K.6
  • 49
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)
    • Scandinavian Simvastatin Survival Study Group
    • Scandinavian Simvastatin Survival Study Group. (1994) Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 344: 1383–1389.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 50
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
    • Shepherd J. Cobbe S.M. Ford I. Isles C.G. Lorimer A.R. Macfarlane P.W. et al (1995) Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med 333: 1301–1307.
    • (1995) N Engl J Med , vol.333 , pp. 1301-1307
    • Shepherd, J.1    Cobbe, S.M.2    Ford, I.3    Isles, C.G.4    Lorimer, A.R.5    Macfarlane, P.W.6
  • 51
    • 77953934908 scopus 로고    scopus 로고
    • Comparative effect of statins vs niacin on MRI measured regression of carotid atherosclerosis in a randomized clinical trial: the NIA Plaque Study
    • Sibley C.T. Gottlieb I. Cox C. Godoy G. Spooner A.E. Bluemke D.A. et al (2009) Comparative effect of statins vs niacin on MRI measured regression of carotid atherosclerosis in a randomized clinical trial: the NIA Plaque Study. Circulation 120: S376–S37a
    • (2009) Circulation , vol.120 , pp. S376-S37a
    • Sibley, C.T.1    Gottlieb, I.2    Cox, C.3    Godoy, G.4    Spooner, A.E.5    Bluemke, D.A.6
  • 52
    • 79959694696 scopus 로고    scopus 로고
    • A meta-analysis of low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein b as markers of cardiovascular risk
    • Sniderman A.D. Williams K. Contois J.H. Monroe H.M. McQueen M.J. de Graaf J. et al (2011) A meta-analysis of low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein b as markers of cardiovascular risk. Circ Cardiovasc Qual Outcomes 4: 337–345.
    • (2011) Circ Cardiovasc Qual Outcomes , vol.4 , pp. 337-345
    • Sniderman, A.D.1    Williams, K.2    Contois, J.H.3    Monroe, H.M.4    McQueen, M.J.5    de Graaf, J.6
  • 53
    • 0023025526 scopus 로고
    • Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT)
    • Stamler J. Wentworth D. Neaton J.D. (1986) Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT). JAMA 256: 2823–2828.
    • (1986) JAMA , vol.256 , pp. 2823-2828
    • Stamler, J.1    Wentworth, D.2    Neaton, J.D.3
  • 54
    • 10044281651 scopus 로고    scopus 로고
    • Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2: a double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins
    • Taylor A.J. Sullenberger L.E. Lee H.J. Lee J.K. Grace K.A. (2004) Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2: a double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins. Circulation 110: 3512–3517.
    • (2004) Circulation , vol.110 , pp. 3512-3517
    • Taylor, A.J.1    Sullenberger, L.E.2    Lee, H.J.3    Lee, J.K.4    Grace, K.A.5
  • 56
    • 0005248386 scopus 로고    scopus 로고
    • US Food and Drug Administration (FDA)
    • Accessed June 23, 2011
    • US Food and Drug Administration (FDA): http://www.fda.gov/Drugs/DrugSafety/ucm256581.htm. Accessed June 23, 2011.
  • 57
    • 55449114841 scopus 로고    scopus 로고
    • Niacin increases HDL by reducing hepatic expression and plasma levels of cholesteryl ester transfer protein in APOE*3Leiden.CETP mice
    • van der Hoorn J.W. de Haan W. Berbee J.F. Havekes L.M. Jukema J.W. Rensen P.C. et al (2008) Niacin increases HDL by reducing hepatic expression and plasma levels of cholesteryl ester transfer protein in APOE*3Leiden.CETP mice. Arterioscler Thromb Vasc Biol 28: 2016–2022.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 2016-2022
    • van der Hoorn, J.W.1    de Haan, W.2    Berbee, J.F.3    Havekes, L.M.4    Jukema, J.W.5    Rensen, P.C.6
  • 58
    • 0028082368 scopus 로고
    • Lipoprotein responses to treatment with lovastatin, gemfibrozil, and nicotinic acid in normolipidemic patients with hypoalphalipoproteinemia
    • Vega G.L. Grundy S.M. (1994) Lipoprotein responses to treatment with lovastatin, gemfibrozil, and nicotinic acid in normolipidemic patients with hypoalphalipoproteinemia. Arch Intern Med 154: 73–82.
    • (1994) Arch Intern Med , vol.154 , pp. 73-82
    • Vega, G.L.1    Grundy, S.M.2
  • 59
    • 77956841888 scopus 로고    scopus 로고
    • The HDL hypothesis: does high-density lipoprotein protect from atherosclerosis?
    • Vergeer M. Holleboom A.G. Kastelein J.J. Kuivenhoven J.A. (2010) The HDL hypothesis: does high-density lipoprotein protect from atherosclerosis? J Lipid Res 51: 2058–2073.
    • (2010) J Lipid Res , vol.51 , pp. 2058-2073
    • Vergeer, M.1    Holleboom, A.G.2    Kastelein, J.J.3    Kuivenhoven, J.A.4
  • 61
    • 70349595967 scopus 로고    scopus 로고
    • Niacin promotes cholesterol efflux through stimulation of the PPARgamma-LXRalpha-ABCA1 pathway in 3T3-L1 adipocytes
    • Wu Z.H. Zhao S.P. (2009) Niacin promotes cholesterol efflux through stimulation of the PPARgamma-LXRalpha-ABCA1 pathway in 3T3-L1 adipocytes. Pharmacology 84: 282–287.
    • (2009) Pharmacology , vol.84 , pp. 282-287
    • Wu, Z.H.1    Zhao, S.P.2
  • 62
    • 0033586641 scopus 로고    scopus 로고
    • Evidence for a new pathophysiological mechanism for coronary artery disease regression: hepatic lipase-mediated changes in LDL density
    • Zambon A. Hokanson J.E. Brown B.G. Brunzell J.D. (1999) Evidence for a new pathophysiological mechanism for coronary artery disease regression: hepatic lipase-mediated changes in LDL density. Circulation 99: 1959–1964.
    • (1999) Circulation , vol.99 , pp. 1959-1964
    • Zambon, A.1    Hokanson, J.E.2    Brown, B.G.3    Brunzell, J.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.