Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice

Endocrinology

Volumn 151, Issue 8, 2010, Pages 3490-3501

  Canalis, Ernesto ^a,b   Zanotti, Stefano ^a   Beamer, Wesley G ^c   Economides, Aris N ^d   Smerdel Ramoya, Anna ^a  

^a SAINT FRANCIS HOSPITAL AND MEDICAL CENTER   (United States)

^b UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^c JACKSON LABORATORY   (United States)

^d REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXY TERMINAL TELOPEPTIDE; CONNECTIVE TISSUE GROWTH FACTOR; CRE RECOMBINASE; OSTEOCALCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; CONTROLLED STUDY; DNA FLANKING REGION; ENCHONDRAL OSSIFICATION; ENHANCER REGION; FEMALE; FEMUR; GENE; GENE DELETION; GENE FUNCTION; GENE INACTIVATION; HETEROZYGOSITY; HOMEOSTASIS; LOXP SITE; MALE; MATING; MORPHOMETRICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; OSTEOPENIA; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PRX1 GENE; SKELETAL HOMEOSTASIS; TISSUE SPECIFICITY; TRABECULAR BONE;

ANIMALS; ANIMALS, NEWBORN; BONE AND BONES; BONE DENSITY; CELLS, CULTURED; CONNECTIVE TISSUE GROWTH FACTOR; ENHANCER ELEMENTS, GENETIC; FEMALE; GROWTH AND DEVELOPMENT; HOMEODOMAIN PROTEINS; HOMEOSTASIS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OSTEOBLASTS; OSTEOCALCIN; OSTEOGENESIS; SEX CHARACTERISTICS;

EID: 77954912746     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0145     Document Type: Article

References (46)

1. Brigstock DR 2003 The CCN family: a new stimulus package. J Endocrinol 178:169-175
2. Brigstock DR, Goldschmeding R, Katsube KI, Lam SC, Lau LF, Lyons K, Naus C, Perbal B, Riser B, Takigawa M, Yeger H 2003 Proposal for a unified CCN nomenclature. Mol Pathol 56:127-128
3. Garcia Abreu J, Coffinier C, Larraín J, Oelgeschläger M, De Robertis EM 2002 Chordin-like CR domains and the regulation of evolutionarily conserved extracellular signaling systems. Gene 287: 39-47 (Pubitemid 34454797)
4. Luo Q, Kang Q, Si W, Jiang W, Park JK, Peng Y, Li X, Luu HH, Luo J, Montag AG, Haydon RC, He TC 2004 Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells. J Biol Chem 279:55958-55968
5. Parisi MS, Gazzerro E, Rydziel S, Canalis E 2006 Expression and regulation of CCN genes in murine osteoblasts. Bone 38:671-677
6. Abreu JG, Ketpura NI, Reversade B, De Robertis EM 2002 Connective- tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β. Nat Cell Biol 4:599-604
7. Mercurio S, Latinkic B, Itasaki N, Krumlauf R, Smith JC 2004 Connective- tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex. Development 131:2137-2147 (Pubitemid 38702045)
8. Song JJ, Aswad R, Kanaan RA, Rico MC, Owen TA, Barbe MF, Safadi FF, Popoff SN 2007 Connective tissue growth factor (CTGF) acts as a downstream mediator of TGF-β1 to induce mesenchymal cell condensation. J Cell Physiol 210:398-410 (Pubitemid 44956885)
9. Iso T, Kedes L, Hamamori Y 2003 HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol 194:237-255 (Pubitemid 36176887)
10. Kopan R, Ilagan MX 2009 The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 137:216-233
11. Smerdel-Ramoya A, Zanotti S, Deregowski V, Canalis E 2008 Connective tissue growth factor enhances osteoblastogenesis in vitro. J Biol Chem 283:22690-22699
12. Ivkovic S, Yoon BS, Popoff SN, Safadi FF, Libuda DE, Stephenson RC, Daluiski A, Lyons KM 2003 Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 130:2779-2791
13. Nishida T, Nakanishi T, Asano M, Shimo T, Takigawa M 2000 Effects of CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, on the proliferation and differentiation of osteoblastic cells in vitro. J Cell Physiol 184:197-206 (Pubitemid 30432311)
14. Safadi FF, Xu J, Smock SL, Kanaan RA, Selim AH, Odgren PR, Marks Jr SC, Owen TA, Popoff SN 2003 Expression of connective tissue growth factor in bone: its role in osteoblast proliferation and differentiation in vitro and bone formation in vivo. J Cell Physiol 196:51-62 (Pubitemid 36676442)
15. Smerdel-Ramoya A, Zanotti S, Stadmeyer L, Durant D, Canalis E 2008 Skeletal overexpression of connective tissue growth factor (CTGF) impairs bone formation and causes osteopenia. Endocrinology 149:4374-4381
16. Valenzuela DM, Murphy AJ, Frendewey D, Gale NW, Economides AN, Auerbach W, Poueymirou WT, Adams NC, Rojas J, Yasenchak J, Chernomorsky R, Boucher M, Elsasser AL, Esau L, Zheng J, Griffiths JA, Wang X, Su H, Xue Y, Dominguez MG, Noguera I, Torres R, Macdonald LE, Stewart AF, DeChiara TM, Yancopoulos GD 2003 High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat Biotechnol 21: 652-659
17. Buchholz F, Ringrose L, Angrand PO, Rossi F, Stewart AF 1996 Different thermostabilities of FLP and Cre recombinases: implications for applied site-specific recombination. Nucleic Acids Res 24: 4256-4262 (Pubitemid 26377344)
18. Buchholz F, Angrand PO, Stewart AF 1998 Improved properties of FLP recombinase evolved by cycling mutagenesis. Nat Biotechnol 16:657-662 (Pubitemid 28334324)
19. Hoess RH, Abremski K 1990 The Cre-lox recombination system. In: Eckstein F, Lilley DMJ, eds. Nucleic acids and molecular biology. Berlin and Heidelberg: Springer-Verlag
20. Sauer B, Henderson N 1988 Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc Natl Acad Sci USA 85:5166-5170
21. Albert H, Dale EC, Lee E, Ow DW 1995 Site-specific integration of DNA into wild-type and mutant lox sites placed in the plant genome. Plant J 7:649-659
22. Oberdoerffer P, Otipoby KL, Maruyama M, Rajewsky K 2003 Unidirectional Cre-mediated genetic inversion in mice using the mutant loxP pair lox66/lox71. Nucleic Acids Res 31:e140
23. Zhang Z, Lutz B 2002 Cre recombinase-mediated inversion using lox66 and lox71: method to introduce conditional point mutations into the CREB-binding protein. Nucleic Acids Res 30:e90
24. Crawford LA, Guney MA, Oh YA, Deyoung RA, Valenzuela DM, Murphy AJ, Yancopoulos GD, Lyons KM, Brigstock DR, Economides A, Gannon M 2009 Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and β-cell proliferation during embryogenesis. Mol Endocrinol 23:324-336
25. Logan M, Martin JF, Nagy A, Lobe C, Olson EN, Tabin CJ 2002 Expression of Cre Recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 33:77-80 (Pubitemid 34651279)
26. Zhang M, Xuan S, Bouxsein ML, von Stechow D, Akeno N, Faugere MC, Malluche H, Zhao G, Rosen CJ, Efstratiadis A, Clemens TL 2002 Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem 277:44005-44012
27. Nazarenko I, Lowe B, Darfler M, Ikonomi P, Schuster D, Rashtchian A 2002 Multiplex quantitative PCR using self-quenched primers labeled with a single fluorophore. Nucleic Acids Res 30:e37
28. Nazarenko I, Pires R, Lowe B, Obaidy M, Rashtchian A 2002 Effect of primary and secondary structure of oligodeoxyribonucleotides on the fluorescent properties of conjugated dyes. Nucleic Acids Res 30:2089-2195 (Pubitemid 34537608)
29. Nagy TR, Prince CW, Li J 2001 Validation of peripheral dual-energy x-ray absorptiometry for the measurement of bone mineral in intact and excised long bones of rats. J Bone Miner Res 16:1682-1687 (Pubitemid 32786438)
30. Gazzerro E, Pereira RC, Jorgetti V, Olson S, Economides AN, Canalis E 2005 Skeletal overexpression of gremlin impairs bone formation and causes osteopenia. Endocrinology 146:655-665 (Pubitemid 40129821)
31. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR 1987 Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 2:595-610
32. Glatt V, Canalis E, Stadmeyer L, Bouxsein ML 2007 Age-related changes in trabecular architecture differ in female and male C57BL/6J mice. J Bone Miner Res 22:1197-1207 (Pubitemid 351339702)
33. McCarthy TL, Centrella M, Canalis E 1988 Further biochemical and molecular characterization of primary rat parietal bone cell cultures. J Bone Miner Res 3:401-408
34. Zanotti S, Smerdel-Ramoya A, Stadmeyer L, Durant D, Radtke F, Canalis E 2008 Notch inhibits osteoblast differentiation and causes osteopenia. Endocrinology 149:3890-3899
35. Kouadjo KE, Nishida Y, Cadrin-Girard JF, Yoshioka M, St-Amand J 2007 Housekeeping and tissue-specific genes in mouse tissues. BMC Genomics 8:127
36. Ryseck RP, Macdonald-Bravo H, Mattéi MG, Bravo R 1991 Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein. Cell Growth Differ 2:225-233
37. Nakanishi T, Yamaai T, Asano M, Nawachi K, Suzuki M, Sugimoto T, Takigawa M 2001 Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism. Biochem Biophys Res Commun 281:678-681 (Pubitemid 32917854)
38. Rydziel S, Stadmeyer L, Zanotti S, Durant D, Smerdel-Ramoya A, Canalis E 2007 Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia. J Biol Chem 282:19762-19772 (Pubitemid 47100103)
39. Canalis E, Smerdel-Ramoya A, Durant D, Economides AN, Beamer WG, Zanotti S 2010 Nephroblastoma overexpressed (NOV) inactivation sensitizes osteoblasts to bone morphogenetic protein-2 but NOV is dispensable for skeletal homeostasis. Endocrinology 151: 221-233
40. Kutz WE, Gong Y, Warman ML 2005 WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice. Mol Cell Biol 25:414-421 (Pubitemid 40039830)
41. Nakamura Y, Cui Y, Fernando C, Kutz WE, Warman ML 2009 Normal growth and development in mice over-expressing the CCN family member WISP3. J Cell Commun Signal 3:105-113
42. Mandal CC, Ghosh Choudhury G, Ghosh-Choudhury N 2009 Phosphatidylinositol 3 kinase/Akt signal relay cooperates with smad in bone morphogenetic protein-2-induced colony stimulating factor- 1 (CSF-1) expression and osteoclast differentiation. Endocrinology 150:4989-4998
43. Mochizuki H, Hakeda Y, Wakatsuki N, Usui N, Akashi S, Sato T, Tanaka K, Kumegawa M 1992 Insulin-like growth factor-I supports formation and activation of osteoclasts. Endocrinology 131:1075-1080
44. Okamoto M, Murai J, Yoshikawa H, Tsumaki N 2006 Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development. J Bone Miner Res 21:1022-1033 (Pubitemid 43962831)
45. Sotillo Rodriguez JE, Mansky KC, Jensen ED, Carlson AE, Schwarz T, Pham L, MacKenzie B, Prasad H, Rohrer MD, Petryk A, Gopalakrishnan R 2009 Enhanced osteoclastogenesis causes osteopenia in twisted gastrulation-deficient mice through increased BMP signaling. J Bone Miner Res 24:1917-1926
46. Zanotti S, Canalis E 2010 Notch and the skeleton. Mol Cell Biol 30:886-896