메뉴 건너뛰기




Volumn 294, Issue 10, 2011, Pages 1646-1652

Alterations in GABAergic biomarkers in the autism brain: Research findings and clinical implications

Author keywords

Autism; BA 40; BA 9; Cerebellum; GABA

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR; BENZODIAZEPINE; BIOLOGICAL MARKER; GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 67; MESSENGER RNA;

EID: 80053029201     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.21252     Document Type: Article
Times cited : (152)

References (50)
  • 2
    • 0021838287 scopus 로고
    • Histoanatomic observations of the brain in early infantile autism
    • Bauman ML, Kemper TL. 1985. Histoanatomic observations of the brain in early infantile autism. Neurology 35: 866-874.
    • (1985) Neurology , vol.35 , pp. 866-874
    • Bauman, M.L.1    Kemper, T.L.2
  • 3
    • 33748957843 scopus 로고    scopus 로고
    • Structural brain anatomy in autism: what is the evidence?
    • In: Bauman ML, Kemper TL, editors 2nd ed. Baltimore, MD: Johns Hopkins University Press
    • Bauman ML, Kemper TL. 2005. Structural brain anatomy in autism: what is the evidence? In: Bauman ML, Kemper TL, editors. The neurobiology of autism. 2nd ed. Baltimore, MD: Johns Hopkins University Press. p 121-135.
    • (2005) The neurobiology of autism , pp. 121-135
    • Bauman, M.L.1    Kemper, T.L.2
  • 4
    • 1842370872 scopus 로고    scopus 로고
    • Differential number of glycine- and GABAimmunopositive neurons and terminals in the deep cerebellar nuclei of normal and Purkinje cell degeneration mutant mice
    • Bäurle J, Grüsser-Cornehls U. 1997. Differential number of glycine- and GABAimmunopositive neurons and terminals in the deep cerebellar nuclei of normal and Purkinje cell degeneration mutant mice. J Comp Neurol 382: 443-458.
    • (1997) J Comp Neurol , vol.382 , pp. 443-458
    • Bäurle, J.1    Grüsser-Cornehls, U.2
  • 5
    • 0027297673 scopus 로고
    • Significance and management of transitory cognitive impairment due to subclinical EEG discharges in children
    • Binnie CD. 1993. Significance and management of transitory cognitive impairment due to subclinical EEG discharges in children. Brain Dev 15: 23-30.
    • (1993) Brain Dev , vol.15 , pp. 23-30
    • Binnie, C.D.1
  • 7
    • 77955126123 scopus 로고    scopus 로고
    • Glutamic acid decarboxylase (GAD) as a biomarker of GABAergic activity in autism: impact on cerebellar circuitry and function
    • In: Blatt GJ, editor New York: Springer
    • Blatt GJ, Soghomonian J-J, Yip J. 2010. Glutamic acid decarboxylase (GAD) as a biomarker of GABAergic activity in autism: impact on cerebellar circuitry and function. In: Blatt GJ, editor. The neurochemical basis of autism. New York: Springer. p 95-112.
    • (2010) The neurochemical basis of autism , pp. 95-112
    • Blatt, G.J.1    Soghomonian, J.-J.2    Yip, J.3
  • 9
    • 0027407430 scopus 로고
    • Colocalization of neurotransmitters in the dentate cerebellar nuclei
    • Chen S, Hillman DE. 1993. Colocalization of neurotransmitters in the dentate cerebellar nuclei. J Neurocytol 22: 81-91.
    • (1993) J Neurocytol , vol.22 , pp. 81-91
    • Chen, S.1    Hillman, D.E.2
  • 10
    • 0023895129 scopus 로고
    • A new combination of WGA-HRP anterograde tracing and GABA immunocytochemistry applied to afferents of the cat inferior olive at the ultrastructural level
    • De Zeeuw CI, Holstege JC, Calkoen F, Ruigrok TJ, Voogd J. 1988. A new combination of WGA-HRP anterograde tracing and GABA immunocytochemistry applied to afferents of the cat inferior olive at the ultrastructural level. Brain Res 447: 369-375.
    • (1988) Brain Res , vol.447 , pp. 369-375
    • De Zeeuw, C.I.1    Holstege, J.C.2    Calkoen, F.3    Ruigrok, T.J.4    Voogd, J.5
  • 14
    • 38049013294 scopus 로고    scopus 로고
    • Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder
    • Delorey TM, Sahbaie P, Hashemi E, Homanics GE, Clark JD. 2008. Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder. Behav Brain Res 187: 207-220.
    • (2008) Behav Brain Res , vol.187 , pp. 207-220
    • Delorey, T.M.1    Sahbaie, P.2    Hashemi, E.3    Homanics, G.E.4    Clark, J.D.5
  • 15
    • 0027243151 scopus 로고
    • Comparative localization of mRNAs encoding two forms of glutamic acid decarboxylase with nonradioactive in situ hybridization methods
    • Esclapez M, Tillakaratne NJ, Tobin AJ, Houser CR. 1993. Comparative localization of mRNAs encoding two forms of glutamic acid decarboxylase with nonradioactive in situ hybridization methods. J Comp Neurol 331: 339-362.
    • (1993) J Comp Neurol , vol.331 , pp. 339-362
    • Esclapez, M.1    Tillakaratne, N.J.2    Tobin, A.J.3    Houser, C.R.4
  • 17
    • 65549088448 scopus 로고    scopus 로고
    • Expression of GABA(B) receptors is altered in brains of subjects with autism
    • Fatemi SH, Folsom TD, Reutiman TJ, Thuras PD. 2009a. Expression of GABA(B) receptors is altered in brains of subjects with autism. Cerebellum 8: 64-69.
    • (2009) Cerebellum , vol.8 , pp. 64-69
    • Fatemi, S.H.1    Folsom, T.D.2    Reutiman, T.J.3    Thuras, P.D.4
  • 19
    • 0025767799 scopus 로고
    • The GABAergic cerebello-olivary projection in the rat
    • Fredette BJ, Mugnaini E. 1991. The GABAergic cerebello-olivary projection in the rat. Anat Embryol 184: 225-243.
    • (1991) Anat Embryol , vol.184 , pp. 225-243
    • Fredette, B.J.1    Mugnaini, E.2
  • 20
    • 0016286435 scopus 로고
    • Some afferent connections of the oculomotor complex in the cat: an experimental study with tracer techniques
    • Graybiel AM, Hartwieg EA. 1974. Some afferent connections of the oculomotor complex in the cat: an experimental study with tracer techniques. Brain Res 81: 543-551.
    • (1974) Brain Res , vol.81 , pp. 543-551
    • Graybiel, A.M.1    Hartwieg, E.A.2
  • 21
    • 34249036179 scopus 로고    scopus 로고
    • 3H]-flunitrazepam-labeled benzodiazepine binding sites in the hippocampal formation in autism: a multiple concentration autoradiographic study
    • 3H]-flunitrazepam-labeled benzodiazepine binding sites in the hippocampal formation in autism: a multiple concentration autoradiographic study. J Autism Dev Disord 37: 911-920.
    • (2007) J Autism Dev Disord , vol.37 , pp. 911-920
    • Guptill, J.T.1    Booker, A.B.2    Gibbs, T.T.3    Kemper, T.L.4    Bauman, M.L.5    Blatt, G.J.6
  • 22
    • 33646473820 scopus 로고    scopus 로고
    • Successive alterations of hippocampal gamma-aminobutyric acid B receptor subunits in a rat model of febrile seizure
    • Han Y, Qin J, Bu DF, Chang XZ, Yang ZX. 2006. Successive alterations of hippocampal gamma-aminobutyric acid B receptor subunits in a rat model of febrile seizure. Life Sci 78: 2944-2952.
    • (2006) Life Sci , vol.78 , pp. 2944-2952
    • Han, Y.1    Qin, J.2    Bu, D.F.3    Chang, X.Z.4    Yang, Z.X.5
  • 23
    • 34247170891 scopus 로고    scopus 로고
    • 15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders
    • Hogart A, Nagarajan RP, Patzel KA, Yasui DH, Lasalle JM. 2007. 15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders. Hum Mol Genet 16: 691-703.
    • (2007) Hum Mol Genet , vol.16 , pp. 691-703
    • Hogart, A.1    Nagarajan, R.P.2    Patzel, K.A.3    Yasui, D.H.4    Lasalle, J.M.5
  • 24
    • 0026027134 scopus 로고
    • Two forms of the gammaaminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions
    • Kaufman DL, Houser CR, Tobin AJ. 1991. Two forms of the gammaaminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions. J Neurochem 56: 720-723.
    • (1991) J Neurochem , vol.56 , pp. 720-723
    • Kaufman, D.L.1    Houser, C.R.2    Tobin, A.J.3
  • 25
    • 0027532518 scopus 로고
    • The contribution of neuropathologic studies to the understanding of autism
    • Kemper TL, Bauman ML. 1993. The contribution of neuropathologic studies to the understanding of autism. Neurol Clin 11: 175-187.
    • (1993) Neurol Clin , vol.11 , pp. 175-187
    • Kemper, T.L.1    Bauman, M.L.2
  • 26
    • 74349087702 scopus 로고    scopus 로고
    • Parvalbumin, calbindin, and calretinin immunoreactive interneuron density in autism
    • Lawrence YL, Kemper TL, Bauman ML, Blatt GJ. 2010. Parvalbumin, calbindin, and calretinin immunoreactive interneuron density in autism. Acta Neurol Scan 121: 99-108.
    • (2010) Acta Neurol Scan , vol.121 , pp. 99-108
    • Lawrence, Y.L.1    Kemper, T.L.2    Bauman, M.L.3    Blatt, G.J.4
  • 27
    • 0027349685 scopus 로고
    • Short-term control of GABA synthesis in brain
    • Martin DL. 1993. Short-term control of GABA synthesis in brain. Prog Biophys Mol Biol 60: 17-28.
    • (1993) Prog Biophys Mol Biol , vol.60 , pp. 17-28
    • Martin, D.L.1
  • 29
    • 25144511541 scopus 로고    scopus 로고
    • Autism and Asperger's disorder: are they movement disorders involving the cerebellum and/or basal ganglia?
    • Nayate A, Bradshaw JL, Rinehart NJ. 2005. Autism and Asperger's disorder: are they movement disorders involving the cerebellum and/or basal ganglia? Brain Res Bull 67: 327-334.
    • (2005) Brain Res Bull , vol.67 , pp. 327-334
    • Nayate, A.1    Bradshaw, J.L.2    Rinehart, N.J.3
  • 30
    • 0004782931 scopus 로고
    • Origins of GABAergic inputs to the inferior olive
    • Strata, editor Berlin: Experimental Brain Research.
    • Nelson BJ, Mugnaini E. 1989. Origins of GABAergic inputs to the inferior olive. In: Strata, editor. The olivocerebellar system in motor control. Berlin: Experimental Brain Research. Vol. 17: p 86-107.
    • (1989) The olivocerebellar system in motor control , vol.17 , pp. 86-107
    • Nelson, B.J.1    Mugnaini, E.2
  • 31
    • 70349313390 scopus 로고    scopus 로고
    • A receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism
    • A receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism. Autism Res 2: 205-219.
    • (2009) Autism Res , vol.2 , pp. 205-219
    • Oblak, A.1    Gibbs, T.T.2    Blatt, G.J.3
  • 32
    • 0019789091 scopus 로고
    • Immunocytochemical localization of glutamate decarboxylase in rat cerebellum with a new antiserum
    • Oertel WH, Schmechel DE, Mugnaini E, Tappaz ML, Kopin IJ. 1981. Immunocytochemical localization of glutamate decarboxylase in rat cerebellum with a new antiserum. Neurosci 6: 2715-2735.
    • (1981) Neurosci , vol.6 , pp. 2715-2735
    • Oertel, W.H.1    Schmechel, D.E.2    Mugnaini, E.3    Tappaz, M.L.4    Kopin, I.J.5
  • 34
    • 0042932590 scopus 로고    scopus 로고
    • Modification of GABA(B1) and GABA(B2) receptor subunits in the somatosensory cerebral cortex and thalamus of rats with absence seizures (GAERS)
    • Princivalle AP, Richards DA, Duncan JS, Spreafico R, Bowery NG. 2003. Modification of GABA(B1) and GABA(B2) receptor subunits in the somatosensory cerebral cortex and thalamus of rats with absence seizures (GAERS). Epilepsy Res 55: 39-51.
    • (2003) Epilepsy Res , vol.55 , pp. 39-51
    • Princivalle, A.P.1    Richards, D.A.2    Duncan, J.S.3    Spreafico, R.4    Bowery, N.G.5
  • 35
    • 0022572835 scopus 로고
    • Lower Purkinje cell counts in the cerebella of four autistic subjects: initial findings of the UCLA-NSAC autopsy research report
    • Ritvo ER, Freeman BJ, Scheibel AB, Duong T, Robinson H, Guthrie D, Ritvo A. 1986. Lower Purkinje cell counts in the cerebella of four autistic subjects: initial findings of the UCLA-NSAC autopsy research report. Am J Psychiatry 143: 862-866.
    • (1986) Am J Psychiatry , vol.143 , pp. 862-866
    • Ritvo, E.R.1    Freeman, B.J.2    Scheibel, A.B.3    Duong, T.4    Robinson, H.5    Guthrie, D.6    Ritvo, A.7
  • 36
    • 0025111332 scopus 로고
    • Cerebellar nucleo-olivary projections in the rat: an anterograde tracing study with Phaseolus vulgaris-leucoagglutinin (PHA-L)
    • Ruigrok TJ, Voogd J. 1990. Cerebellar nucleo-olivary projections in the rat: an anterograde tracing study with Phaseolus vulgaris-leucoagglutinin (PHA-L). J Comp Neurol 298: 315-333.
    • (1990) J Comp Neurol , vol.298 , pp. 315-333
    • Ruigrok, T.J.1    Voogd, J.2
  • 37
    • 0019505101 scopus 로고
    • Sources of descending afferents to the inferior olive from upper brainstem in the cat as revealed by the retrograde transport of horseradish peroxidase
    • Saint-Cyr JA, Courville J. 1981. Sources of descending afferents to the inferior olive from upper brainstem in the cat as revealed by the retrograde transport of horseradish peroxidase. J Comp Neurol 198: 567-581.
    • (1981) J Comp Neurol , vol.198 , pp. 567-581
    • Saint-Cyr, J.A.1    Courville, J.2
  • 38
    • 14044252235 scopus 로고    scopus 로고
    • Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3
    • Samaco RC, Hogart A, LaSalle JM. 2005. Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3. Hum Mol Genet 14: 483-492.
    • (2005) Hum Mol Genet , vol.14 , pp. 483-492
    • Samaco, R.C.1    Hogart, A.2    LaSalle, J.M.3
  • 40
    • 1642504438 scopus 로고    scopus 로고
    • Rapid and long-term alterations of hippocampal GABAB receptors in a mouse model of temporal lobe epilepsy
    • Straessle A, Loup F, Arabadzisz D, Ohning GV, Fritschy JM. 2003. Rapid and long-term alterations of hippocampal GABAB receptors in a mouse model of temporal lobe epilepsy. Eur J Neurosci 18: 2213-2226.
    • (2003) Eur J Neurosci , vol.18 , pp. 2213-2226
    • Straessle, A.1    Loup, F.2    Arabadzisz, D.3    Ohning, G.V.4    Fritschy, J.M.5
  • 41
    • 80053014512 scopus 로고    scopus 로고
    • Altered GABA-A receptor binding in the posterolateral cerebellar hemisphere and the dentate nucleus in autism
    • Thevarkunnel S, Gibbs TT, Marcon R, Antzoulatos E, Oblak A, Bauman ML. 2006. Altered GABA-A receptor binding in the posterolateral cerebellar hemisphere and the dentate nucleus in autism. Soc Neurosci Conf PP61, 692.14.
    • (2006) Soc Neurosci Conf , vol.61 , pp. 69214
    • Thevarkunnel, S.1    Gibbs, T.T.2    Marcon, R.3    Antzoulatos, E.4    Oblak, A.5    Bauman, M.L.6
  • 42
    • 0018073018 scopus 로고
    • Organizational features of the cat and monkey nucleocortical projection
    • Tolbert DL, Bantli H, Bloedel JR. 1978. Organizational features of the cat and monkey nucleocortical projection. J Comp Neurol 182: 39-56.
    • (1978) J Comp Neurol , vol.182 , pp. 39-56
    • Tolbert, D.L.1    Bantli, H.2    Bloedel, J.R.3
  • 44
    • 0036960321 scopus 로고    scopus 로고
    • Functional significance of climbing fiber synchrony: a population coding and behavioral analysis
    • Welsh JP. 2002. Functional significance of climbing fiber synchrony: a population coding and behavioral analysis. Ann N Y Acad Sci 978: 188-204.
    • (2002) Ann N Y Acad Sci , vol.978 , pp. 188-204
    • Welsh, J.P.1
  • 45
    • 53849140787 scopus 로고    scopus 로고
    • Cerebellar Purkinje cells are reduced in a subpopulation of autistic brains: a stereological experiment using calbindin-D28k
    • Whitney ER, Kemper TL, Bauman ML, Rosene DL, Blatt GJ. 2008. Cerebellar Purkinje cells are reduced in a subpopulation of autistic brains: a stereological experiment using calbindin-D28k. Cerebellum 7: 406-416.
    • (2008) Cerebellum , vol.7 , pp. 406-416
    • Whitney, E.R.1    Kemper, T.L.2    Bauman, M.L.3    Rosene, D.L.4    Blatt, G.J.5
  • 46
    • 69249229837 scopus 로고    scopus 로고
    • Density of cerebellar basket and stellate cells in autism: evidence for a late developmental loss of Purkinje cells
    • Whitney ER, Kemper TL, Bauman ML, Rosene DL, Blatt GJ. 2009. Density of cerebellar basket and stellate cells in autism: evidence for a late developmental loss of Purkinje cells. J Neurosci Res 87: 2245-2254.
    • (2009) J Neurosci Res , vol.87 , pp. 2245-2254
    • Whitney, E.R.1    Kemper, T.L.2    Bauman, M.L.3    Rosene, D.L.4    Blatt, G.J.5
  • 47
    • 0019205798 scopus 로고
    • Autism and mental retardation: neuropathologic studies performed in four retarded persons with autistic behavior
    • Williams RS, Hauser SL, Purpura DP, DeLong GR, Swisher CN. 1980. Autism and mental retardation: neuropathologic studies performed in four retarded persons with autistic behavior. Arch Neurol 37: 749-753.
    • (1980) Arch Neurol , vol.37 , pp. 749-753
    • Williams, R.S.1    Hauser, S.L.2    Purpura, D.P.3    DeLong, G.R.4    Swisher, C.N.5
  • 48
    • 34247631067 scopus 로고    scopus 로고
    • Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: pathophysiological implications
    • Yip J, Soghomonian JJ, Blatt GJ. 2007. Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: pathophysiological implications. Acta Neuropathol 113: 559-568.
    • (2007) Acta Neuropathol , vol.113 , pp. 559-568
    • Yip, J.1    Soghomonian, J.J.2    Blatt, G.J.3
  • 49
    • 38849164392 scopus 로고    scopus 로고
    • Increased GAD67 mRNA levels in cerebellar interneurons in autism: implications for Purkinje cell dysfunction
    • Yip J, Soghomonian JJ, Blatt GJ. 2008. Increased GAD67 mRNA levels in cerebellar interneurons in autism: implications for Purkinje cell dysfunction. J Neurosci Res 86: 525-530.
    • (2008) J Neurosci Res , vol.86 , pp. 525-530
    • Yip, J.1    Soghomonian, J.J.2    Blatt, G.J.3
  • 50
    • 63449095687 scopus 로고    scopus 로고
    • Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study
    • Yip J, Soghomonian JJ, Blatt GJ. 2009. Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study. Autism Res 2: 50-59.
    • (2009) Autism Res , vol.2 , pp. 50-59
    • Yip, J.1    Soghomonian, J.J.2    Blatt, G.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.