Asymmetric synthesis of LFA-1 inhibitor BIRT2584 on metric ton scale

Organic Process Research and Development

Volumn 15, Issue 5, 2011, Pages 1185-1191

  Wang, Xiao Jun ^a   Frutos, Rogelio P ^a   Zhang, Li ^a   Sun, Xiufeng ^a   Xu, Yibo ^a   Wirth, Thomas ^b   Nicola, Thomas ^b   Nummy, Lawrence J ^a   Krishnamurthy, Dhileep ^a   Busacca, Carl A ^a   Yee, Nathan ^a   Senanayake, Chris H ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASYMMETRIC SYNTHESIS; ONE POT; REGIOSELECTIVE BROMINATION; SELF-REGENERATION; STEREOCENTERS; SULFONYL CHLORIDES;

CHLORINE COMPOUNDS; REACTION INTERMEDIATES; SULFUR DIOXIDE; UREA;

REGIOSELECTIVITY;

EID: 80053027468     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op200175t     Document Type: Article

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