Immunoselection and clinical use of T regulatory cells in HLA-haploidentical stem cell transplantation

Best Practice and Research: Clinical Haematology

Volumn 24, Issue 3, 2011, Pages 459-466

  Di Ianni, Mauro ^a,b   Falzetti, Franca ^a   Carotti, Alessandra ^a   Terenzi, Adelmo ^a   Del Papa, Beatrice ^a   Perruccio, Katia ^a   Ruggeri, Loredana ^a   Sportoletti, Paolo ^a   Rosati, Emanuela ^a   Marconi, Pierfrancesco ^a   Falini, Brunangelo ^a   Reisner, Yair ^c   Velardi, Andrea ^a   Aversa, Franco ^a   Martelli, Massimo F ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF L'AQUILA   (Italy)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

GvHD; haploidentical transplantation; Treg

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOCYTIC LEUKEMIA; ADULT; ARTICLE; CD34 SELECTION; CD4 LYMPHOCYTE COUNT; CD4+ CD25+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; FEMALE; FOLLOW UP; GRAFT VERSUS HOST REACTION; HLA HAPLOIDENTICAL STEM CELL TRANSPLANTATION; HUMAN; LYMPHOCYTE COUNT; MALE; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; STEM CELL TRANSPLANTATION;

EID: 80053017373     PISSN: 15216926     EISSN: 15321924     Source Type: Journal    
DOI: 10.1016/j.beha.2011.05.005     Document Type: Review

References (35)

1. F. Aversa, A. Tabilio, and A. Velardi Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype N Engl J Med 339 1998 1186 1193 (Pubitemid 28482127)
2. F. Aversa, A. Terenzi, and A. Tabilio Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse J Clin Oncol 23 2005 3447 3454
3. G.M. Davison, N. Novitzky, and A. Kline Immune reconstitution after allogeneic bone marrow transplantation depleted of T cells Transplantation 69 2000 1341 1347 (Pubitemid 30238721)
4. P. Hoffmann, J. Ermann, and M. Edinger Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation J Exp Med 196 2002 389 399 (Pubitemid 34875667)
5. J.L. Cohen, A. Trenado, and D. Vasey CD4(+)CD25(+) immunoregulatory T cells: new therapeutics for graft-versus-host disease J Exp Med 196 2002 401 406 (Pubitemid 34875668)
6. P.A. Taylor, C.J. Lees, and B.R. Blazar The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality Blood 99 2002 3493 3499 (Pubitemid 34534513)
7. M. Edinger, P. Hoffmann, and J. Ermann CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation Nat Med 9 2003 1144 1150 (Pubitemid 37173698)
8. A. Trenado, F. Charlotte, and S. Fisson Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia J Clin Invest 112 2003 1688 1696 (Pubitemid 38063726)
9. S.C. Jones, G.F. Murphy, and R. Korngold Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response Biol Blood Marrow Transplant 9 2003 243 256 (Pubitemid 40045611)
10. V.H. Nguyen, S. Shashidhar, and D.S. Chanq The impact of regulatory T cells on T cell immunity following hematopoeitic cell transplantation Blood 111 2008 945 953
11. C. Baecher-Allan, J.A. Brown, and G.J. Freeman HaflerDA. CD4+CD25 high regulatory cells in human peripheral blood J Immunol 167 2001 1245 1253 (Pubitemid 32703119)
12. S. Zelenay, T. Lopes-Carvalho, and I. Caramalho FoxP3+CD25-CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion Proc Natl Acad Sci USA 102 2005 4091 4096 (Pubitemid 40388560)
13. J.D. Fontenot, J.P. Rasmussen, and L.M. Willliams Regulatory T cell lineage specification by the forkhead transcription factor FoxP3 Immunity 22 2005 329 341 (Pubitemid 40387475)
14. L.M. Williams, and A. Rudensky Maintenance of the FoxP3-dependent developmental program in mature regulatory T cells requires continued expression of FoxP3 Nat Immunol 8 2007 277 284 (Pubitemid 46745377)
15. M.A. Gavin, T.R. Torgerson, and E. Houston Single-cell analysis of normal and FoxP3-mutant human T cells: FoxP3 expression without regulatory T cell development Proc Natl Acad Sci USA 103 2006 6659 6664
16. K. Kretschmer, I. Apostolou, and D. Hawiger Inducing and expanding regulatory T cell populations by foreign antigen Nat Immunol 6 2005 1219 1227 (Pubitemid 43045633)
17. N. Seddiki, B. Santner-Nanan, and J. Martinson Expression of interleukin (IL)-2 and Il-7 receptors discriminates between human regulatory and activated T cells J Exp Med 7 2006 1693 1700 (Pubitemid 44036275)
18. W. Liu, A.L. Putnam, and Z. Xu-Yu CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells J Exp Med 203 2006 1701 1711 (Pubitemid 44036276)
19. M. Di Ianni, B. Del Papa, and D. Cecchini Immunomagnetic isolation of CD4+CD25+FoxP3+ natural T regulatory lymphocytes for clinical applications Clin Exp Immunol 156 2 2009 246 253
20. M. Di Ianni, F. Falzetti, and A. Carotti Tregs prevent GvHD and promote immune reconstitution in HLA-haploidentical transplantation Blood 117 2011 3921 3928
21. N. Eiraku, R. Hingorani, and S. Ijichi Clonal expansion within CD4+ and CD8+ T cell subsets in human T lymphotropic virus type I-infected individuals J Immunol 161 12 1998 6674 6680 (Pubitemid 28562209)
22. K. Perruccio, A. Tosti, and E. Burchielli Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation Blood 106 2005 4397 4406 (Pubitemid 41775954)
23. D.C. Douek, R.D. McFarland, and P.H. Keiser Changes in thymic function with age and during the treatment of HIV infection Nature 396 1998 690 695 (Pubitemid 29003949)
24. J. Shimizu, S. Yamazaki, and S. Sakaguchi Induction of tumor immunity by removing CD25+CD4+ T cells: a common ba sis between tumor immunity and autoimmunity J Immunol 163 1999 5211 5218
25. K. Le Blanc, I. Rasmusson, and B. Sunberg Treatment of severe graft-versus-host disease with third party haploidentical mesenchymal stem cells Lancet 363 2004 1439 1441 (Pubitemid 38586721)
26. M.K. Levings, R. Sangregorio, and M.G. Roncarolo Human CD4+CD25+ T regulatory cells suppress naïve and memory T cell proliferation and can be expanded in vitro without loss of function J Exp Med 193 2001 1295 1301 (Pubitemid 32524779)
27. D.M. Weinstock, G.G. Ambrossi, and C. Brennan Preemptive diagnosis and treatment of Epstein-Barr virus associated post transplant lymphoproliferative disorder after hematopoietic stem cell transplantation: an approach in development Bone Marrow Transplant 37 2006 539 546 (Pubitemid 43378825)
28. D.J. Hartigan-O'Connor, C. Poon, and E. Sinclair Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells J Immunol Methods 319 2007 41 52 (Pubitemid 46110995)
29. S.J. Bensinger, P.T. Walsh, and J. Zhang Distinct IL-2 receptor signalling patterns in CD4+CD25+ regulatory T cells J Immunol 172 2004 5287 5296 (Pubitemid 38542026)
30. M. Di Ianni, B. Del Papa, and M. De Ioanni Mesenchymal cells recruit and regulate T regulatory cells Exp Hematol 36 2008 309 318 (Pubitemid 351221170)
31. pos depletion, Treg expansion, and Treg cryopreservation PloS One 3 2008 1 9
32. V.H. Nguyen, R. Zeiser, D.L. daSilva, and D.L. daSilva In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation Blood 109 2007 2649 2656 (Pubitemid 46425916)
33. C.F. Craddock Full-intensity and reduced-intensity allogeneic stem cell transplantation in AML Bone Marrow Transpl 41 2008 415 423 (Pubitemid 351386707)
34. W. Arcese, V. Rocha, and M. Labopin Unrelated cord blood transplants in adults with hematologic malignancies Haematologica 91 2006 223 230
35. L. Ruggeri, M. Capanni, and E. Urbani Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants Science 295 2002 2097 2100 (Pubitemid 34229476)