Structural basis of the substrate specificity of bifunctional isocitrate dehydrogenase kinase/phosphatase

Biochemistry

Volumn 50, Issue 38, 2011, Pages 8103-8106

  Yates, Susan P ^a   Edwards, Thomas E ^b,c   Bryan, Cassie M ^b,d   Stein, Adam J ^b,c   Van Voorhis, Wesley C ^b,d   Myler, Peter J ^b,e   Stewart, Lance J ^b,c   Zheng, Jimin ^f   Jia, Zongchao ^a,f  

^a QUEEN S UNIVERSITY   (Canada)

^b SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^c Emerald BioStructures Inc   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF WASHINGTON   (United States)

^f BEIJING NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIFUNCTIONAL; BURKHOLDERIA PSEUDOMALLEI; GLYOXYLATE; GRAM-NEGATIVE BACTERIA; ISOCITRATE DEHYDROGENASE; KINETIC ANALYSIS; STRUCTURAL BASIS; STRUCTURAL ELEMENTS; SUBSTRATE SPECIFICITY;

BACTERIA; BINDING SITES; ESCHERICHIA COLI; SUBSTRATES;

CRYSTAL STRUCTURE;

GLYOXYLIC ACID; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE (NADP); ISOCITRATE DEHYDROGENASE KINASE; ISOCITRATE DEHYDROGENASE PHOSPHATASE; UNCLASSIFIED DRUG;

ARTICLE; BURKHOLDERIA PSEUDOMALLEI; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL;

BURKHOLDERIA PSEUDOMALLEI; CATALYTIC DOMAIN; DIMERIZATION; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GRAM-NEGATIVE BACTERIA; ISOCITRATE DEHYDROGENASE; KINETICS; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, QUATERNARY; SUBSTRATE SPECIFICITY;

BURKHOLDERIA PSEUDOMALLEI; ESCHERICHIA COLI; NEGIBACTERIA;

EID: 80053002310     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200809p     Document Type: Article

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