Epidermal growth factor improves survival and prevents intestinal injury in a murine model of pseudomonas aeruginosa pneumonia

Shock

Volumn 36, Issue 4, 2011, Pages 381-389

  Dominguez, Jessica A ^a   Vithayathil, Paul J ^b   Khailova, Ludmila ^a   Lawrance, Christopher P ^b   Samocha, Alexandr J ^b   Jung, Enjae ^b   Leathersich, Ann M ^b   Dunne, W Michael ^b   Coopersmith, Craig M ^c  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

epidermal growth factor; intestine; pneumonia; Pseudomonas aeruginosa; Sepsis

Indexed keywords

CYTOKINE; EPIDERMAL GROWTH FACTOR; FATTY ACID BINDING PROTEIN; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFICACY; INTESTINE CELL; INTESTINE EPITHELIUM CELL; INTESTINE INJURY; INTESTINE VILLUS; KIDNEY FUNCTION; LIVER FUNCTION; MORTALITY; MOUSE; NONHUMAN; PATHOLOGY; PSEUDOMONAS PNEUMONIA; RANDOMIZED CONTROLLED TRIAL; SPLEEN CELL; SURVIVAL;

ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; EPIDERMAL GROWTH FACTOR; INTESTINAL DISEASES; INTESTINES; MICE; MICE, TRANSGENIC; PEROXIDASE; PNEUMONIA; PSEUDOMONAS AERUGINOSA;

EID: 80052967969     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e31822793c4     Document Type: Article

References (35)

1. Heron M, Hoyert DL, Murphy SL, Xu J, Kochanek KD, Tejada-Vera B: Deaths: final data for 2006. Natl Vital Stat Rep 57(14):1-134, 2009.
2. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20(6):864-874, 1992.
3. Clark JA, Coopersmith CM: Intestinal crosstalk: a new paradigm for understanding the gut as the Bmotor[ of critical illness. Shock 28(4):384-393, 2007. (Pubitemid 47421846)
4. Hassoun HT, Kone BC, Mercer DW, Moody FG, Weisbrodt NW, Moore FA: Post-injury multiple organ failure: the role of the gut. Shock 15(1):1-10, 2001. (Pubitemid 33598153)
5. Coopersmith CM, Stromberg PE, Dunne WM, Davis CG, Amiot DM, Buchman TG, Karl IE, Hotchkiss RS: Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis. JAMA 287(13): 1716-1721, 2002. (Pubitemid 34289225)
6. Coopersmith CM, Chang KC, Swanson PE, Tinsley KW, Stromberg PE, Buchman TG, Karl IE, Hotchkiss RS: Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice. Crit Care Med 30(1):195-201, 2002. (Pubitemid 34112196)
7. Fox AC, Robertson CM, Belt B, Clark AT, Chang KC, Leathersich AM, Dominguez JA, Perrone EE, Dunne WM, Hotchkiss RS, et al.: Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis. Crit Care Med 38(3):886-893, 2010.
8. Coopersmith CM, Stromberg PE, Davis CG, Dunne WM, Amiot DM, Karl IE, Hotchkiss RS, Buchman TG: Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest. Crit Care Med 31(6):1630-1637, 2003. (Pubitemid 36714214)
9. Mainous MR, Ertel W, Chaudry IH, Deitch EA: The gut: a cytokine-generating organ in systemic inflammation? Shock 4(3):193-199, 1995.
10. Clark JA, Gan H, Samocha AJ, Fox AC, Buchman TG, Coopersmith CM: Enterocyte-specific epidermal growth factor prevents barrier dysfunction and improves mortality in murine peritonitis. Am J Physiol Gastrointest Liver Physiol 297(3):G471-G479, 2009.
11. Neal MD, Leaphart C, Levy R, Prince J, Billiar TR, Watkins S, Li J, Cetin S, Ford H, Schreiber A, et al.: Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier. J Immunol 176(5): 3070-3079, 2006.
12. Dominguez JA, Coopersmith CM: Can we protect the gut in critical illness? The role of growth factors and other novel approaches. Crit Care Clin 26(3): 549-565, 2010.
13. Jones MK, Tomikawa M, Mohajer B, Tarnawski AS: Gastrointestinal mucosal regeneration: role of growth factors. Front Biosci 4:D303-D309, 1999.
14. Bernal NP, Stehr W, Coyle R, Erwin CR, Warner BW: Epidermal growth factor receptor signaling regulates Bax and Bcl-w expression and apoptotic responses during intestinal adaptation in mice. Gastroenterology 130(2):412-423, 2006. (Pubitemid 43202040)
15. Clark JA, Lane RH, Maclennan NK, Holubec H, Dvorakova K, Halpern MD, Williams CS, Payne CM, Dvorak B: Epidermal growth factor reduces intestinal apoptosis in an experimental model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 88(4):G755-G762, 2005. (Pubitemid 40388187)
16. Halpern MD, Dominguez JA, Dvorakova K, Holubec H, Williams CS, Meza YG, Ruth MC, Dvorak B: Ileal cytokine dysregulation in experimental necrotizing enterocolitis is reduced by epidermal growth factor. J Pediatr Gastroenterol Nutr 36(1):126-133, 2003. (Pubitemid 41672632)
17. Clark JA, Clark AT, Hotchkiss RS, Buchman TG, Coopersmith CM: Epidermal growth factor treatment decreases mortality and is associated with improved gut integrity in sepsis. Shock 30(1):36-42, 2008.
18. Clark JA, Doelle SM, Halpern MD, Saunders TA, Holubec H, Dvorak K, Boitano SA, Dvorak B: Intestinal barrier failure during experimental necrotizing enterocolitis: protective effect of EGF treatment. Am J Physiol Gastrointest Liver Physiol 91(5):G938-G949, 2006. (Pubitemid 44772020)
19. Dvorak B, Halpern MD, Holubec H, Williams CS, McWilliam DL, Dominguez JA, Stepankova R, Payne CM, McCuskey RS: Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model. Am J Physiol Gastrointest Liver Physiol 82(1):G156-G164, 2002. (Pubitemid 34650110)
20. Berlanga J, Prats P, Remirez D, Gonzalez R, Lopez-Saura P, Aguiar J, Ojeda M, Boyle JJ, Fitzgerald AJ, Playford RJ: Prophylactic use of epidermal growth factor reduces ischemia/reperfusion intestinal damage. Am J Pathol 161(2): 373-379, 2002. (Pubitemid 36142145)
21. McConnell KW, McDunn JE, Clark AT, Dunne WM, Dixon DJ, Turnbull IR, Dipasco PJ, Osberghaus WF, Sherman B, Martin JR, et al.: Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses. Crit Care Med 38(1):223-241, 2010.
22. Husain KD, Stromberg PE, Javadi P, Buchman TG, Karl IE, Hotchkiss RS, Coopersmith CM: Bcl-2 inhibits gut epithelial apoptosis induced by acute lung injury in mice but has no effect on survival. Shock 20(5):437-443, 2003.
23. Erwin CR, Helmrath MA, Shin CE, Falcone RA Jr, Stern LE, Warner BW: Intestinal overexpression of EGF in transgenic mice enhances adaptation after small bowel resection. Am J Physiol 277(3 Pt 1):G533-G540, 1999. (Pubitemid 29458225)
24. Robertson CM, Perrone EE, McConnell KW, Dunne WM, Boody B, Brahmbhatt T, Julia DM, Van RN, Hogue LA, Cannon CL, et al.: Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance. J Surg Res 150(2):278-285, 2008.
25. Vyas D, Robertson CM, Stromberg PE, Martin JR, Dunne WM, Houchen CW, Barrett TA, Ayala A, Perl M, Buchman TG, et al.: Epithelial apoptosis in mechanistically distinct methods of injury in the murine small intestine. Histol Histopathol 22(6):623-630, 2007. (Pubitemid 46647274)
26. ClinicalTrials.gov. http://clinicaltrials.gov/ct2/results?term= epidermal+growth+ factor. Accessed May 18, 2011.
27. Yu P, Martin CM: Increased gut permeability and bacterial translocation in Pseudomonas pneumoniaYinduced sepsis. Crit Care Med 28(7):2573-2577, 2000. (Pubitemid 30604472)
28. Miettinen PJ, Berger JE, Meneses J, Phung Y, Pedersen RA, Werb Z, Derynck R: Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376(6538):337-341, 1995.
29. Puddicombe SM, Polosa R, Richter A, Krishna MT, Howarth PH, Holgate ST, Davies DE: Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J 14(10):1362-1374, 2000. (Pubitemid 30439745)
30. Kheradmand F, Folkesson HG, Shum L, Derynk R, Pytela R, Matthay MA: Transforming growth factor-alpha enhances alveolar epithelial cell repair in a new in vitro model. Am J Physiol 267(6 Pt 1):L728-L738, 1994.
31. Barrow RE, Wang CZ, Evans MJ, Herndon DN: Growth factors accelerate epithelial repair in sheep trachea. Lung 171(6):335-344, 1993. (Pubitemid 23325616)
32. Bierman A, Yerrapureddy A, Reddy NM, Hassoun PM, Reddy SP: Epidermal growth factor receptor (EGFR) regulates mechanical ventilation-induced lung injury in mice. Transl Res 152(6):265-272, 2008.
33. Wiley HS: Trafficking of the ErbB receptors and its influence on signaling. Exp Cell Res 284(1):78-88, 2003. (Pubitemid 36331967)
34. Hotchkiss RS, Strasser A, McDunn JE, Swanson PE: Cell death. N Engl J Med 361(16):1570-1583, 2009.
35. Rocourt DV, Mehta VB, Besner GE: Heparin-binding EGF-like growth factor decreases inflammatory cytokine expression after intestinal ischemia/reperfusion injury. J Surg Res 139(2):269-273, 2007. (Pubitemid 46551173)