Changes of chondrocyte expression profiles in human MSC aggregates in the presence of PEG microspheres and TGF-β3

Biomaterials

Volumn 32, Issue 33, 2011, Pages 8436-8445

  Ravindran, Soumya ^a   Roam, Jacob L ^a   Nguyen, Peter K ^a   Hering, Thomas M ^b   Elbert, Donald L ^a   McAlinden, Audrey ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Cartilage tissue engineering; Chondrocyte; Mesenchymal stem cell; Microsphere; Polyethylene; TGF

Indexed keywords

AGGREGATE CULTURE; CARTILAGE TISSUE ENGINEERING; CELL PHENOTYPE; CELLULAR INTERACTION; CHONDROCYTE; CHONDROCYTES; CHONDROGENIC DIFFERENTIATION; CULTURE SYSTEMS; EXPRESSION PATTERNS; EXPRESSION PROFILE; GROWTH FACTOR; GROWTH FACTOR DELIVERY; ISOFORMS; MESENCHYMAL STEM CELL; MICRO-PARTICLES; PROCOLLAGEN; PROTEIN LOCALIZATION; SPECIFIC AREAS; TO EFFECT; TYPE II COLLAGENS; TYPE X COLLAGEN;

AGGREGATES; BIOMATERIALS; BIOSYNTHESIS; BODY FLUIDS; COLLAGEN; ETHYLENE; FLOWCHARTING; GENE EXPRESSION; GLYCOLS; MICROSPHERES; PEPTIDES; POLYETHYLENE GLYCOLS; POLYETHYLENES; STEM CELLS; TISSUE; TISSUE ENGINEERING;

CELL CULTURE;

COLLAGEN TYPE 1; COLLAGEN TYPE 10; COLLAGEN TYPE 2; MACROGOL; TRANSFORMING GROWTH FACTOR BETA3;

ARTICLE; CARTILAGE CELL; CELL AGGREGATION; CELL CULTURE; CELL DIFFERENTIATION; CELL INTERACTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STROMA CELL;

ACTINS; CELL DIFFERENTIATION; CELLS, CULTURED; CHONDROCYTES; COLLAGEN TYPE II; COLLAGEN TYPE X; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELLS; MICROSPHERES; OLIGOPEPTIDES; POLYETHYLENE GLYCOLS; PROTEOGLYCANS; REAL-TIME POLYMERASE CHAIN REACTION; TRANSFORMING GROWTH FACTOR BETA3;

EID: 80052967002     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.07.056     Document Type: Article

References (53)

1. Ulrich-Vinther M., Maloney M.D., Schwarz E.M., Rosier R., O'Keefe R.J. Articular cartilage biology. J Am Acad Orthop Surg 2003, 11:421-430.
2. Hollander A.P., Dickinson S.C., Kafienah W. Stem cells and cartilage development: complexities of a simple tissue. Stem Cells 2010, 28:1992-1996.
3. Daher R.J., Chahine N.O., Greenberg A.S., Sgaglione N.A., Grande D.A. New methods to diagnose and treat cartilage degeneration. Nat Rev Rheumatol 2009, 5:599-607.
4. Nelson L., Fairclough J., Archer C.W. Use of stem cells in the biological repair of articular cartilage. Expert Opin Biol Ther 2010, 10:43-55.
5. Keeney M., Lai J.H., Yang F. Recent progress in cartilage tissue engineering. Curr Opin Biotechnol 2011, Available from URL. http://www.ncbi.nlm.nih.gov/pubmed/21531126, 10.1016/j.copbio.2011.04.003.
6. Toh W.S., Spector M., Lee E.H., Cao T. Biomaterial-Mediated delivery of Microenvironmental Cues for repair and regeneration of articular cartilage. Mol Pharmacol 2011, Available from URL. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DCitation%26list_uids%3D21500855, 10.1021/mp100437a.
7. Spiller K.L., Maher S.A., Lowman A.M. Hydrogels for the repair of articular cartilage defects. Tissue Eng Part B Rev 2011, Available from URL. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DCitation%26list_uids%3D21510824, 10.1089/ten.TEB.2011.0077.
8. Vinatier C., Mrugala D., Jorgensen C., Guicheux J., Noel D. Cartilage engineering: a crucial combination of cells, biomaterials and biofactors. Trends Biotechnol 2009, 27:307-314.
9. Place E.S., Evans N.D., Stevens M.M. Complexity in biomaterials for tissue engineering. Nat Mater 2009, 8:457-470.
10. Han Y., Wei Y., Wang S., Song Y. Cartilage regeneration using adipose-derived stem cells and the controlled-released hybrid microspheres. Jt Bone Spine 2010, 77:27-31.
11. Solorio L.D., Fu A.S., Hernandez-Irizarry R., Alsberg E. Chondrogenic differentiation of human mesenchymal stem cell aggregates via controlled release of TGF-beta1 from incorporated polymer microspheres. J Biomed Mater Res A 2010, 92:1139-1144.
12. Andreas K., Zehbe R., Kazubek M., Grzeschik K., Sternberg N., Baumler H., et al. Biodegradable insulin-loaded PLGA microspheres fabricated by three different emulsification techniques: investigation for cartilage tissue engineering. Acta Biomater 2011, 7:1485-1495.
13. Jha A.K., Yang W., Kirn-Safran C.B., Farach-Carson M.C., Jia X. Perlecan domain I-conjugated, hyaluronic acid-based hydrogel particles for enhanced chondrogenic differentiation via BMP-2 release. Biomaterials 2009, 30:6964-6975.
14. Kang S.W., La W.G., Kim B.S. Open macroporous poly(lactic-co-glycolic Acid) microspheres as an injectable scaffold for cartilage tissue engineering. J Biomater Sci Polym Ed 2009, 20:399-409.
15. Jaklenec A., Wan E., Murray M.E., Mathiowitz E. Novel scaffolds fabricated from protein-loaded microspheres for tissue engineering. Biomaterials 2008, 29:185-192.
16. Jaklenec A., Hinckfuss A., Bilgen B., Ciombor D.M., Aaron R., Mathiowitz E. Sequential release of bioactive IGF-I and TGF-beta 1 from PLGA microsphere-based scaffolds. Biomaterials 2008, 29:1518-1525.
17. Scholten P.M., Ng K.W., Joh K., Serino L.P., Warren R.F., Torzilli P.A., et al. A semi-degradable composite scaffold for articular cartilage defects. J Biomed Mater Res A 2011, Available from URL. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DCitation%26list_uids%3D21308980, 10.1002/jbm.a.33005.
18. Johnstone B., Hering T.M., Caplan A.I., Goldberg V.M., Yoo J.U. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res 1998, 238:265-272.
19. Scott E.A., Nichols M.D., Cordova L.H., George B.J., Jun Y.S., Elbert D.L. Protein adsorption and cell adhesion on nanoscale bioactive coatings formed from poly(ethylene glycol) and albumin microgels. Biomaterials 2008, 29:4481-4493.
20. Nuttelman C.R., Tripodi M.C., Anseth K.S. Synthetic hydrogel niches that promote hMSC viability. Matrix Biol 2005, 24:208-218.
21. Ruoslahti E., Pierschbacher M.D. New perspectives in cell adhesion: RGD and integrins. Science 1987, 238:491-497.
22. Salinas C.N., Anseth K.S. The influence of the RGD peptide motif and its contextual presentation in PEG gels on human mesenchymal stem cell viability. J Tissue Eng Regen Med 2008, 2:296-304.
23. Lim J.J., Hammoudi T.M., Bratt-Leal A.M., Hamilton S.K., Kepple K.L., Bloodworth N.C., et al. Development of nano- and microscale chondroitin sulfate particles for controlled growth factor delivery. Acta Biomater 2011, 7:986-995.
24. Bratt-Leal A.M., Carpenedo R.L., Ungrin M.D., Zandstra P.W., McDevitt T.C. Incorporation of biomaterials in multicellular aggregates modulates pluripotent stem cell differentiation. Biomaterials 2011, 32:48-56.
25. Wacker B.K., Alford S.K., Scott E.A., Das Thakur M., Longmore G.D., Elbert D.L. Endothelial cell migration on RGD-peptide-containing PEG hydrogels in the presence of sphingosine 1-phosphate. Biophys J 2008, 94:273-285.
26. Roam J.L., Xu H., Nguyen P.K., Elbert D.L. The formation of protein concentration gradients mediated by density differences of poly(ethylene glycol) microspheres. Biomaterials 2010, 31:8642-8650.
27. Zaragosi L.E., Ailhaud G., Dani C. Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells. Stem Cells 2006, 24:2412-2419.
28. Coutu D.L., Francois M., Galipeau J. Inhibition of cellular senescence by developmentally regulated FGF-receptors in mesenchymal stem cells. Blood 2011, Available from URL. http://www.ncbi.nlm.nih.gov/pubmed/21527526, 10.1182/blood-2010-12-321539.
29. Cremer M.A., Kang A.H. Collagen-induced arthritis in rodents: a review of immunity to type II collagen with emphasis on the importance of molecular conformation and structure. Int Rev Immunol 1988, 4:65-81.
30. Gibson G., Lin D.L., Francki K., Caterson B., Foster B. Type X collagen is colocalized with a proteoglycan epitope to form distinct morphological structures in bovine growth cartilage. Bone 1996, 19:307-315.
31. McAlinden A., Johnstone B., Kollar J., Kazmi N., Hering T.M. Expression of two novel alternatively spliced COL2A1 isoforms during chondrocyte differentiation. Matrix Biol 2008, 27:254-266.
32. Barry F., Boynton R.E., Liu B., Murphy J.M. Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components. Exp Cell Res 2001, 268:189-200.
33. Yoo J.U., Barthel T.S., Nishimura K., Solchaga L., Caplan A.I., Goldberg V.M., et al. The chondrogenic potential of human bone-marrow-derived mesenchymal progenitor cells. J Bone Jt Surg Am 1998, 80:1745-1757.
34. Mahoney M.J., Saltzman W.M. Transplantation of brain cells assembled around a programmable synthetic microenvironment. Nat Biotechnol 2001, 19:934-939.
35. Ferreira L., Squier T., Park H., Choe H., Kohane D.S., Langer R. Human embryoid bodies containing nano- and microparticulate delivery vehicles. Adv Mater 2008, 20:2285.
36. Bouffi C., Thomas O., Bony C., Giteau A., Venier-Julienne M.C., Jorgensen C., et al. The role of pharmacologically active microcarriers releasing TGF-beta3 in cartilage formation in vivo by mesenchymal stem cells. Biomaterials 2010, 31:6485-6493.
37. Carpenedo R.L., Bratt-Leal A.M., Marklein R.A., Seaman S.A., Bowen N.J., McDonald J.F., et al. Homogeneous and organized differentiation within embryoid bodies induced by microsphere-mediated delivery of small molecules. Biomaterials 2009, 30:2507-2515.
38. Carpenedo R.L., Seaman S.A., McDevitt T.C. Microsphere size effects on embryoid body incorporation and embryonic stem cell differentiation. J Biomed Mater Res A 2010, 94:466-475.
39. Elbert D.L. Liquid-liquid two-phase systems for the production of porous hydrogels and hydrogel microspheres for biomedical applications: a tutorial review. Acta Biomater 2011, 7:31-56.
40. Scott E.A., Nichols M.D., Kuntz-Willits R., Elbert D.L. Modular scaffolds assembled around living cells using poly(ethylene glycol) microspheres with macroporation via a non-cytotoxic porogen. Acta Biomater 2010, 6:29-38.
41. Elbert D.L. Bottom-up tissue engineering. Curr Opin Biotechnol 2011, Available from URL. http://www.ncbi.nlm.nih.gov/pubmed/21524904, 10.1016/j.copbio.2011.04.001).
42. Nichols M.D., Scott E.A., Elbert D.L. Factors affecting size and swelling of poly(ethylene glycol) microspheres formed in aqueous sodium sulfate solutions without surfactants. Biomaterials 2009, 30:5283-5291.
43. Narita Y., Yamawaki A., Kagami H., Ueda M., Ueda Y. Effects of transforming growth factor-beta 1 and ascorbic acid on differentiation of human bone-marrow-derived mesenchymal stem cells into smooth muscle cell lineage. Cell Tissue Res 2008, 333:449-459.
44. Kurpinski K., Lam H., Chu J., Wang A., Kim A., Tsay E., et al. Transforming growth factor-beta and notch signaling mediate stem cell differentiation into smooth muscle cells. Stem Cells 2010, 28:734-742.
45. Kinner B., Zaleskas J.M., Spector M. Regulation of smooth muscle actin expression and contraction in adult human mesenchymal stem cells. Exp Cell Res 2002, 278:72-83.
46. Ghazanfari S., Tafazzoli-Shadpour M., Shokrgozar M.A. Effects of cyclic stretch on proliferation of mesenchymal stem cells and their differentiation to smooth muscle cells. Biochem Biophys Res Commun 2009, 388:601-605.
47. Ryan M.C., Sandell L.J. Differential expression of a cysteine-rich domain in the amino-terminal propeptide of type II (cartilage) procollagen by alternative splicing of mRNA. J Biol Chem 1990, 265:10334-10339.
48. Ichinose S., Tagami M., Muneta T., Sekiya I. Morphological examination during in vitro cartilage formation by human mesenchymal stem cells. Cell Tissue Res 2005, 322:217-226.
49. Nalin A.M., Greenlee T.K., Sandell L.J. Collagen gene expression during development of avian synovial joints: transient expression of types II and XI collagen genes in the joint capsule. Dev Dyn 1995, 203:352-362.
50. Pelttari K., Winter A., Steck E., Goetzke K., Hennig T., Ochs B.G., et al. Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum 2006, 54:3254-3266.
51. Rich J.T., Rosova I., Nolta J.A., Myckatyn T.M., Sandell L.J., McAlinden A. Upregulation of Runx2 and Osterix during in vitro chondrogenesis of human adipose-derived stromal cells. Biochem Biophys Res Commun 2008, 372:230-235.
52. Rucklidge G.J., Milne G., Robins S.P. Collagen type X: a component of the surface of normal human, pig, and rat articular cartilage. Biochem Biophys Res Commun 1996, 224:297-302.
53. Bahney C.S., Hsu C.W., Yoo J.U., West J.L., Johnstone B. A bioresponsive hydrogel tuned to chondrogenesis of human mesenchymal stem cells. FASEB J 2011, 25:1486-1496.