The formation of protein concentration gradients mediated by density differences of poly(ethylene glycol) microspheres

Biomaterials

Volumn 31, Issue 33, 2010, Pages 8642-8650

  Roam, Jacob L ^a   Xu, Hao ^a   Nguyen, Peter K ^a   Elbert, Donald L ^a  

^a WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

Gradient; Heparin; Hydrogel; Microsphere; Protein

Indexed keywords

BIOACTIVE MOLECULES; CLOUD POINTS; CONCENTRATION GRADIENTS; CRITICAL ELEMENTS; CROSS-LINK DENSITIES; DENSITY DIFFERENCE; GRADIENT; GRADIENT SCAFFOLD; GRADUAL TRANSITION; GROWTH FACTOR; HEPARIN; IMMOBILIZED PROTEINS; INCUBATION PERIODS; INCUBATION TIME; PROOF OF CONCEPT; PROTEIN CONCENTRATIONS; PROTEIN RELEASE; SCAFFOLDS FOR TISSUE ENGINEERING; SELF-ASSEMBLED; SHARP INTERFACE; SULFATE SOLUTIONS; THERMALLY INDUCED PHASE SEPARATION;

CENTRIFUGATION; COAGULATION; ETHYLENE; ETHYLENE GLYCOL; GELATION; GROWTH KINETICS; HYDROGELS; PHASE SEPARATION; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYSACCHARIDES; PROTEINS; SCAFFOLDS; SIZE SEPARATION; SODIUM; SODIUM SULFATE; TISSUE ENGINEERING;

MICROSPHERES;

GROWTH FACTOR; MACROGOL; MICROSPHERE; PROTAMINE; SODIUM SULFATE;

AQUEOUS SOLUTION; ARTICLE; CENTRIFUGATION; COVALENT BOND; DENSITY; GELATION; INCUBATION TIME; KINETICS; PARTICLE SIZE; PHASE SEPARATION; PRIORITY JOURNAL; TEMPERATURE DEPENDENCE; TISSUE ENGINEERING;

ANIMALS; CATTLE; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HEPARIN; HUMANS; MICROSPHERES; POLYETHYLENE GLYCOLS; PROTAMINES; PROTEINS; SERUM ALBUMIN, BOVINE; STATIC ELECTRICITY;

EID: 77957298825     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.07.085     Document Type: Article

References (45)

1. Cao X., Shoichet M.S. Defining the concentration gradient of nerve growth factor for guided neurite outgrowth. Neuroscience 2001, 103:831-840.
2. DeLong S.A., Moon J.J., West J.L. Covalently immobilized gradients of bfgf on hydrogel scaffolds for directed cell migration. Biomaterials 2005, 26:3227-3234.
3. Fisher P.R., Merkl R., Gerisch G. Quantitative-analysis of cell motility and chemotaxis in dictyostelium-discoideum by using an image-processing system and a novel chemotaxis chamber providing stationary chemical gradients. J Cell Biol 1989, 108:973-984.
4. Kapur T.A., Shoichet M.S. Immobilized concentration gradients of nerve growth factor guide neurite outgrowth. J Biomed Mater Res Part A 2004, 68A:235-243.
5. Knapp D.M., Helou E.F., Tranquillo R.T. A fibrin or collagen gel assay for tissue cell chemotaxis: assessment of fibroblast chemotaxis to grgdsp. Exp Cell Res 1999, 247:543-553.
6. Moore K., Macsween M., Shoichet M. Immobilized concentration gradients of neurotrophic factors guide neurite outgrowth of primary neurons in macroporous scaffolds. Tissue Eng 2006, 12:267-278.
7. Parent C.A., Devreotes P.N. A cell's sense of direction. Science 1999, 284:765-770.
8. Rosoff W.J., Urbach J.S., Esrick M.A., McAllister R.G., Richards L.J., Goodhill G.J. A new chemotaxis assay shows the extreme sensitivity of axons to molecular gradients. Nat Neurosci 2004, 7:678-682.
9. Singh M., Morris C.P., Ellis R.J., Detamore M.S., Berkland C. Microsphere-based seamless scaffolds containing macroscopic gradients of encapsulated factors for tissue engineering. Tissue Eng Part C Methods 2008, 14:299-309.
10. Song H.J., Ming G.L., Poo M.M. Camp-induced switching in turning direction of nerve growth cones. Nature 1997, 388:275-279.
11. Song H.J., Poo M.M. The cell biology of neuronal navigation. Nat Cell Biol 2001, 3:E81-E88.
12. Wang X.Q., Wenk E., Zhang X.H., Meinel L., Vunjak-Novakovic G., Kaplan D.L. Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering. J Control Release 2009, 134:81-90.
13. Dodla M.C., Bellamkonda R.V. Anisotropic scaffolds facilitate enhanced neurite extension in vitro. J Biomed Mater Res A 2006, 78A:213-221.
14. Dodla M.C., Bellamkonda R.V. Differences between the effect of anisotropic and isotropic laminin and nerve growth factor presenting scaffolds on nerve regeneration across long peripheral nerve gaps. Biomaterials 2008, 29:33-46.
15. Drury J.L., Mooney D.J. Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials 2003, 24:4337-4351.
16. Scott E.A., Nichols M.D., Kuntz-Willits R., Elbert D.L. Modular scaffolds assembled around living cells using poly(ethylene glycol) microspheres with macroporation via a non-cytotoxic porogen. Acta Biomater 2010, 6:29-38.
17. Tessmar J.K., Gopferich A.M. Customized peg-derived copolymers for tissue-engineering applications. Macromol Biosci 2007, 7:23-39.
18. Almany L., Seliktar D. Biosynthetic hydrogel scaffolds made from fibrinogen and polyethylene glycol for 3D cell cultures. Biomaterials 2005, 26:2467-2477.
19. Lutolf M.P., Hubbell J.A. Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat Biotechnol 2005, 23:47-55.
20. Zhang G., Wang X.H., Wang Z.L., Zhang J.Y., Suggs L. A pegylated fibrin patch for mesenchymal stem cell delivery. Tissue Eng 2006, 12:9-19.
21. Khademhosseini A., Langer R. Microengineered hydrogels for tissue engineering. Biomaterials 2007, 28:5087-5092.
22. Rivest C., Morrison D.W.G., Ni B., Rubin J., Yadav V., Mahdavi A., et al. Microscale hydrogels for medicine and biology: synthesis, characteristics and applications. J Mech Mater Struct 2007, 2:1103-1119.
23. Du Y.A., Lo E., Ali S., Khademhosseini A. Directed assembly of cell-laden microgels for fabrication of 3D tissue constructs. Proc Natl Acad Sci U S A 2008, 105:9522-9527.
24. Serban M.A., Prestwich G.D. Modular extracellular matrices: solutions for the puzzle. Methods 2008, 45:93-98.
25. Yeh J., Ling Y.B., Karp J.M., Gantz J., Chandawarkar A., Eng G., et al. Micromolding of shape-controlled, harvestable cell-laden hydrogels. Biomaterials 2006, 27:5391-5398.
26. Thomas B., Tao X., Brook D., Xiaofeng C. Application of inkjet printing to tissue engineering. Biotechnol J 2006, 1:910-917.
27. Tsang V.L., Bhatia S.N. Three-dimensional tissue fabrication. Adv Drug Deliv Rev 2004, 56:1635-1647.
28. Um E., Lee D.S., Pyo H.B., Park J.K. Continuous generation of hydrogel beads and encapsulation of biological materials using a microfluidic droplet-merging channel. Microfluid Nanofluidics 2008, 5:541-549.
29. Nichols M.D., Scott E.A., Elbert D.L. Factors affecting size and swelling of poly(ethylene glycol) microspheres formed in aqueous sodium sulfate solutions without surfactants. Biomaterials 2009, 30:5283-5291.
30. Wacker B.K., Scott E.A., Kaneda M.M., Alford S.K., Elbert D.L. Delivery of sphingosine 1-phosphate from poly(ethylene glycol) hydrogels. Biomacromolecules 2006, 7:1335-1343.
31. Elbert D.L., Hubbell J.A. Self-assembly and steric stabilization at heterogeneous, biological surfaces using adsorbing block copolymers. Chem Biol 1998, 5:177-183.
32. Kenausis G.L., Voros J., Elbert D.L., Huang N.P., Hofer R., Ruiz-Taylor L., et al. Poly(l-lysine)-g-poly(ethylene glycol) layers on metal oxide surfaces: attachment mechanism and effects of polymer architecture on resistance to protein adsorption. J Phys Chem B 2000, 104:3298-3309.
33. Barras F.M., Pasche P., Bouche N., Aebischer P., Zurn A.D. Glial cell line-derived neurotrophic factor released by synthetic guidance channels promotes facial nerve regeneration in the rat. J Neurosci Res 2002, 70:746-755.
34. Fine E.G., Decosterd I., Papaloizos M., Zurn A.D., Aebischer P. Gdnf and ngf released by synthetic guidance channels support sciatic nerve regeneration across a long gap. Eur J Neurosci 2002, 15:589-601.
35. Nie T., Baldwin A., Yamaguchi N., Kiick K.L. Production of heparin-functionalized hydrogels for the development of responsive and controlled growth factor delivery systems. J Control Release 2007, 122:287-296.
36. Sakiyama-Elbert S.E., Hubbell J.A. Development of fibrin derivatives for controlled release of heparin-binding growth factors. J Control Release 2000, 65:389-402.
37. Tae G., Scatena M., Stayton P.S., Hoffman A.S. Peg-cross-linked heparin is an affinity hydrogel for sustained release of vascular endothelial growth factor. J Biomater Sci Polym Ed 2006, 17:187-197.
38. Scott D.C., Hollenbeck R.G. Design and manufacture of a zero-order sustained-release pellet dosage form through nonuniform drug distribution in a diffusional matrix. Pharm Res 1991, 8:156-161.
39. Flory P.J. Principles of polymer chemistry 1953, Cornell University Press.
40. Crank J. The mathematics of diffusion 1975, Clarendon Press, Oxford.
41. Maxwell D.J., Hicks B.C., Parsons S., Sakiyama-Elbert S.E. Development of rationally designed affinity-based drug delivery systems. Acta Biomater 2005, 1:101-113.
42. Jaques L.B. The reaction of heparin with proteins and complex bases. Biochem J 1942, 37:189-195.
43. Jones G.R., Hashim R., Power D.M. A comparison of the strength of binding of antithrombin III, protamine and poly(-lysine) to heparin samples of different anicoagulant activities. Biochim Biophys Acta 1986, 883:69-76.
44. Morimoto K., Katsumata H., Yabuta T., Iwanaga K., Kakemi M., Tabata Y., et al. Gelatin microspheres as a pulmonary delivery system: evaluation of salmon calcitonin absorption. J Pharm Pharmacol 2000, 52:611-617.
45. Park H., Temenoff J.S., Holland T.A., Tabata Y., Mikos A.G. Delivery of tgf-beta 1 and chondrocytes via injectable, biodegradable hydrogels for cartilage tissue engineering applications. Biomaterials 2005, 26:7095-7103.