Tenocyte apoptosis in the torn rotator cuff: A primary or secondary pathological event?

British Journal of Sports Medicine

Volumn 45, Issue 13, 2011, Pages 1035-1039

  Lundgreen, Kirsten ^a   Lian, Øystein Bjerkestrand ^b   Engebretsen, Lars ^c   Scott, Alex ^d  

^a LOVISENBERG DIAKONALE HOSPITAL   (Norway)

^b Kristiansand Hospital HNR   (Norway)

^c ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN P53;

AGED; APOPTOSIS; ARTICLE; CELL PROLIFERATION; DRUG ANTAGONISM; FEMALE; GENE EXPRESSION; GENETICS; HUMAN; INJURY; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; ROTATOR CUFF; RUPTURE; TENDINITIS; TUMOR SUPPRESSOR GENE;

AGED; APOPTOSIS; CELL PROLIFERATION; FEMALE; GENE EXPRESSION; GENES, P53; HUMANS; MALE; MIDDLE AGED; RNA, MESSENGER; ROTATOR CUFF; RUPTURE; TENDINOPATHY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 80052962207     PISSN: 03063674     EISSN: 14730480     Source Type: Journal    
DOI: 10.1136/bjsm.2010.083188     Document Type: Article

References (50)

1. Bunker T. Rotator cuff disease. Curr Orthop 2002; 16: 223-33.
2. Rolf C, Movin T. Etiology, histopathology, and outcome of surgery in achillodynia. Foot Ankle Int 1997; 18: 565-9. (Pubitemid 27418068)
3. Kader D, Saxena A, Movin T, et al. Achilles tendinopathy: some aspects of basic science and clinical management. Br J Sports Med 2002; 36: 239-49. (Pubitemid 34833115)
4. Clegg PD, Strassburg S, Smith RK. Cell phenotypic variation in normal and damaged tendons. Int J Exp Pathol 2007; 88: 227-35. (Pubitemid 47256310)
5. Bishop J, Klepps S, Lo IK, et al. Cuff integrity after arthroscopic versus open rotator cuff repair: a prospective study. J Shoulder Elbow Surg 2006; 15: 290-9.
6. Boileau P, Brassart N, Watkinson DJ, et al. Arthroscopic repair of full-thickness tears of the supraspinatus: does the tendon really heal? J Bone Joint Surg Am 2005; 87: 1229-40. (Pubitemid 40756623)
7. Galatz LM, Ball CM, Teefey SA, et al. The outcome and repair integrity of completely arthroscopically repaired large and massive rotator cuff tears. J Bone Joint Surg Am 2004; 86-A: 219-24. (Pubitemid 38141554)
8. Verma NN, Dunn W, Adler RS, et al. All-arthroscopic versus mini-open rotator cuff repair: a retrospective review with minimum 2-year follow-up. Arthroscopy 2006; 22: 587-94. (Pubitemid 43817418)
9. Sugaya H, Maeda K, Matsuki K, et al. Functional and structural outcome after arthroscopic full-thickness rotator cuff repair: single-row versus dual-row fi xation. Arthroscopy 2005;2 1: 1307-16. (Pubitemid 41735195)
10. Sugaya H, Maeda K, Matsuki K, et al. Repair integrity and functional outcome after arthroscopic double-row rotator cuff repair. A prospective outcome study. J Bone Joint Surg Am 2007; 89: 953-60. (Pubitemid 46724584)
11. Lichtenberg S, Liem D, Magosch P, et al. Infl uence of tendon healing after arthroscopic rotator cuff repair on clinical outcome using single-row Mason-Allen suture technique: a prospective, MRI controlled study. Knee Surg Sports Traumatol Arthrosc 2006; 14: 1200-6. (Pubitemid 44705170)
12. Voigt C, Bosse C, Vosshenrich R, et al. Arthroscopic supraspinatus tendon repair with suture-bridging technique: functional outcome and magnetic resonance imaging. Am J Sports Med 2010; 38: 983-91.
13. Lafosse L, Brozska R, Toussaint B, et al. The outcome and structural integrity of arthroscopic rotator cuff repair with use of the double-row suture anchor technique. J Bone Joint Surg Am 2007; 89: 1533-41. (Pubitemid 47041531)
14. Ide J, Tokiyoshi A, Hirose J, et al. Arthroscopic repair of traumatic combined rotator cuff tears involving the subscapularis tendon. J Bone Joint Surg Am 2007; 89: 2378-88. (Pubitemid 350086326)
15. Lui PP, Cheuk YC, Hung LK, et al. Increased apoptosis at the late stage of tendon healing. Wound Repair Regen 2007; 15: 702-7. (Pubitemid 47493888)
16. Li G, White G, Connolly C, et al. Cell proliferation and apoptosis during fracture healing. J Bone Miner Res 2002; 17: 791-9. (Pubitemid 34441895)
17. Wu YF, Chen CH, Cao Y, et al. Molecular events of cellular apoptosis and proliferation in the early tendon healing period. J Hand Surg Am 2010; 35: 2-10.
18. Jellinger KA, Bancher C. Neuropathology of Alzheimer's disease: a critical update. J Neural Transm Suppl 1998; 54: 77-95. (Pubitemid 28539345)
19. Amin AR, Abramson SB. The role of nitric oxide in articular cartilage breakdown in osteoarthritis. Curr Opin Rheumatol 1998; 10: 263-8. (Pubitemid 28286819)
20. Chikanza I, Fernandes L. Novel strategies for the treatment of osteoarthritis. Expert Opin Investig Drugs 2000; 9: 1499-510. (Pubitemid 30433710)
21. Lotz M, Hashimoto S, Kühn K. Mechanisms of chondrocyte apoptosis. Osteoarthr Cartil 1999; 7: 389-91. (Pubitemid 29331557)
22. Unglaub F, Thomas SB, Kroeber MW, et al. Apoptotic pathways in degenerative disk lesions in the wrist. Arthroscopy 2009; 25: 1380-6.
23. B enson R T, McDonnell SM, Knowles HJ, et al. Tendinopathy and tears of the rotator cuff are associated with hypoxia and apoptosis. J Bone Joint Surg Br 2010; 92: 448-53.
24. Chen J, Wang A, Xu J, et al. In chronic lateral epicondylitis, apoptosis and autophagic cell death occur in the extensor carpi radialis brevis tendon. J Shoulder Elbow Surg 2010; 19: 355-62.
25. Lian Ø, Scott A, Engebretsen L, et al. Excessive apoptosis in patellar tendinopathy in athletes. Am J Sports Med 2007; 35: 605-11. (Pubitemid 46953067)
26. P earce C J, I smail M, Calder JD. I s apoptosis the cause of noninsertional achilles tendinopathy? Am J Sports Med 2009; 37: 2440-4.
27. Scott A, Khan KM, Duronio V. IGF-I activates PKB and prevents anoxic apoptosis in Achilles tendon cells. J Orthop Res 2005; 23: 1219-25. (Pubitemid 41245451)
28. Scott A, Khan KM, Heer J, et al. High strain mechanical loading rapidly induces tendon apoptosis: an ex vivo rat tibialis anterior model. Br J Sports Med 2005; 39: e25.
29. T uoheti Y, I toi E, Pradhan RL, et al. Apoptosis in the supraspinatus tendon with stage II subacromial impingement. J Shoulder Elbow Surg 2005; 14: 535-41. (Pubitemid 41376558)
30. Yuan J, Wang MX, Murrell GA. Cell death and tendinopathy. Clin Sports Med 2003; 22: 693-701. (Pubitemid 37175571)
31. Y uan J, Murrell GA, Wei AQ, et al. Apoptosis in rotator cuff tendonopathy. J Orthop Res 2002; 20: 1372-9. (Pubitemid 35363999)
32. Chuen F S, Chuk CY, Ping WY, et al. Immunohistochemical characterization of cells in adult human patellar tendons. J Histochem Cytochem 2004; 52: 1151-7. (Pubitemid 39097182)
33. Millar NL, Wei AQ, Molloy TJ, et al. Cytokines and apoptosis in supraspinatus tendinopathy. J Bone Joint Surg Br 2009; 91: 417-24.
34. M illar N L, Wei AQ, Molloy TJ, et al. H eat shock protein and apoptosis in supraspinatus tendinopathy. Clin Orthop Relat Res 2008; 466: 1569-76.
35. Wu B, Chen J, Rosa TD, et al. Cellular response and extracellular matrix breakdown in rotator cuff tendon rupture. Arch Orthop Trauma Surg 2011; 131: 405-11.
36. Grasl-Kraupp B, Ruttkay-Nedecky B, Koudelka H, et al. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note. Hepatology 1995; 21: 1465-8.
37. Unglaub F, Wolf MB, Dragu A, et al. Molecular events of cellular apoptosis and proliferation in the early tendon healing period. J Hand Surg Am 2010; 35: 691-2.
38. Van Cruchten S, Van Den Broeck W. Morphological and biochemical aspects of apoptosis, oncosis and necrosis. Anat Histol Embryol 2002; 31: 214-23.
39. V ogelstein B, Lane D, Levine AJ. Surfi ng the p53 network. Nature 2000; 408: 307-10.
40. C ook J L, Feller JA, Bonar SF, et al. Abnormal tenocyte morphology is more prevalent than collagen disruption in asymptomatic athletes' patellar tendons. J Orthop Res 2004; 22: 334-8. (Pubitemid 38155289)
41. Maffulli N, Longo UG, Franceschi F, et al. Movin and Bonar scores assess the same characteristics of tendon histology. Clin Orthop Relat Res 2008; 466: 1605-11.
42. V ousden K H, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2002;2: 594-604. (Pubitemid 37328926)
43. K im M M, Yoon SO, Cho YS, et al. H istone deacetylases, HDAC1 and HSIR2, act as a negative regulator of ageing through p53 in human gingival fi broblast. Mech Ageing Dev 2004; 125: 351-7. (Pubitemid 38595186)
44. Le Guezennec X, Bulavin DV. WIP1 phosphatase at the crossroads of cancer and aging. Trends Biochem Sci 2010; 35: 109-14.
45. M ancini F, Di Conza G, Monti O, et al. Puzzling over MDM4-p53 network. Int J Biochem Cell Biol 2010; 42: 1080-3.
46. F rankfurt O S, Robb JA, Sugarbaker EV, et al. Monoclonal antibody to singlestranded DNA is a specifi c and sensitive cellular marker of apoptosis. Exp Cell Res 1996; 226: 387-97. (Pubitemid 26260564)
47. E gerbacher M, Arnoczky SP, Caballero O, et al. Loss of homeostatic tension induces apoptosis in tendon cells: an in vitro study. Clin Orthop Relat Res 2008; 466: 1562-8.
48. Matthews T J, Hand GC, Rees JL, et al. Pathology of the torn rotator cufftendon. Reduction in potential for repair as tear size increases. J Bone Joint Surg Br 2006; 88: 489-95.
49. Post M, Silver R, Singh M. Rotator cuff tear. Diagnosis and treatment. Clin Orthop Relat Res 1983: 78-91. (Pubitemid 13115030)
50. Scott A, Cook JL, Hart DA, et al. Tenocyte responses to mechanical loading in vivo: a role for local insulin-like growth factor 1 signaling in early tendinosis in rats. Arthritis Rheum 2007; 56: 871-81. (Pubitemid 46399435)