Molecular Events of Cellular Apoptosis and Proliferation in the Early Tendon Healing Period

Journal of Hand Surgery

Volumn 35, Issue 1, 2010, Pages 2-10

  Wu, Ya Fang ^a   Chen, Chuan Hao ^a   Cao, Yi ^a   Avanessian, Bella ^a   Wang, Xiao Tian ^a   Tang, Jin Bo ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

apoptosis; cellular proliferation; early healing period; Tendon healing

Indexed keywords

CELL NUCLEUS ANTIGEN; DNA NUCLEOTIDYLEXOTRANSFERASE; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CHICKEN; CONTROLLED STUDY; FLEXOR TENDON; HEALING; IMMUNOFLUORESCENCE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; TENDON; TENDON RECONSTRUCTION;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL PROLIFERATION; CHICKENS; IN SITU NICK-END LABELING; MEMBRANE PROTEINS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTO-ONCOGENE PROTEINS; TENDONS; TOES; WOUND HEALING;

EID: 72449172088     PISSN: 03635023     EISSN: 15316564     Source Type: Journal    
DOI: 10.1016/j.jhsa.2009.10.021     Document Type: Article

References (35)

1. Duffy F.J., Seiler J.G., Gelberman R.H., and Hergrueter C.A. Growth factors and canine flexor tendon healing: initial studies in uninjured and repair models. J Hand Surg 20A (1995) 645-649
2. Chan B.P., Chan K.M., Maffulli N., Webb S., and Lee K.K. Effect of basic fibroblast growth factor. An in vitro study of tendon healing. Clin Orthop Relat Res 342 (1997) 239-247
3. Chang J., Most D., Thunder R., Mehrara B., Longaker M.T., and Lineaweaver W.C. Molecular studies in flexor tendon wound healing: the role of basic fibroblast growth factor gene expression. J Hand Surg 23A (1998) 1052-1058
4. Zhang A.Y., Pham H., Ho F., Teng K., Longaker M.T., and Chang J. Inhibition of TGF-beta-induced collagen production in rabbit flexor tendons. J Hand Surg 29A (2004) 230-235
5. Wang X.T., Liu P.Y., Xin K.Q., and Tang J.B. Tendon healing in vitro: bFGF gene transfer to tenocytes by adeno-associated viral vectors promotes expression of collagen genes. J Hand Surg 30A (2005) 1255-1261
6. Tang J.B., Cao Y., Zhu B., Xin K.Q., Wang X.T., and Liu P.Y. Adeno-associated virus-2-mediated bFGF gene transfer to digital flexor tendons significantly increases healing strength. an in vivo study. J Bone Joint Surg 90A (2008) 1078-1089
7. Cohen G.M. Caspases: the executioners of apoptosis. Biochem J 326 (1997) 1-16
8. Mariathasan S., Newton K., Monack D.M., Vucic D., French D.M., Lee W.P., et al. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430 (2004) 213-218
9. Chao D.T., and Korsmeyer S.J. BCL-2 family: regulators of cell death. Annu Rev Immunol 16 (1998) 395-419
10. Barkhausen T., van Griensven M., Zeichen J., and Bosch U. Modulation of cell functions of human tendon fibroblasts by different repetitive cyclic mechanical stress patterns. Exp Toxicol Pathol 55 (2003) 153-158
11. Skutek M., van Griensven M., Zeichen J., Brauer N., and Bosch U. Cyclic mechanical stretching of human patellar tendon fibroblasts: activation of JNK and modulation of apoptosis. Knee Surg Sports Traumatol Arthrosc 11 (2003) 122-129
12. Scott A., Khan K.M., Heer J., Cook J.L., Lian O., and Duronio V. High strain mechanical loading rapidly induces tendon apoptosis: an ex vivo rat tibialis anterior model. Br J Sports Med 39 (2005) e25
13. Yuan J., Murrell G.A., Wei A.Q., and Wang M.X. Apoptosis in rotator cuff tendinopathy. J Orthop Res 20 (2002) 1372-1379
14. Yuan J., Wang M.X., and Murrell G.A. Cell death and tendinopathy. Clin Sports Med 22 (2003) 693-701
15. Lui P.P., Cheuk Y.C., Hung L.K., Fu S.C., and Chan K.M. Increased apoptosis at the late stage of tendon healing. Wound Repair Regen 15 (2007) 702-707
16. Elliot D., Barbieri C.H., Evans R.B., Mass D., and Tang J.B. IFSSH Flexor Tendon Committee Report 2007. J Hand Surg 32E (2007) 346-356
17. Elliot D., Moiemen N.S., Flemming A.F., Harris S.B., and Foster A.J. The rupture rate of acute flexor tendon repairs mobilized by the controlled active motion regimen. J Hand Surg 19B (1994) 607-612
18. Tang J.B. Indications, methods, postoperative motion and outcome evaluation of primary flexor tendon repairs in Zone 2. J Hand Surg 32E (2007) 118-129
19. Kubota H., Manske P.R., Aoki M., Pruitt D.L., and Larson B.J. Effect of motion and tension on injured flexor tendons in chickens. J Hand Surg 21A (1996) 456-463
20. Tang J.B. Clinical outcomes associated with flexor tendon repair. Hand Clin 21 (2005) 199-210
21. Farkas L.G., Thomson H.G., and Martin R. Some practical notes on the anatomy of chicken toe for surgeon investigators. Plast Reconstr Surg 54 (1974) 452-458
22. Manske P.R., Lesker P.A., and Bridwell K. Experimental studies in chickens on the initial nutrition of tendon grafts. J Hand Surg 4A (1979) 565-575
23. Peterson W.W., Manske P.R., Kain C.C., and Lesker P.A. Effect of flexor sheath integrity on tendon gliding: a biomechanical and histologic study. J Orthop Res 4 (1986) 458-465
24. Xu Y., and Tang J.B. Effects of superficialis tendon repairs on lacerated profundus tendons within or proximal to the A2 pulley: an in vivo study in chickens. J Hand Surg 28A (2003) 944-1001
25. Cao Y., Chen C.H., Wu Y.F., Xu X.F., Xie R.G., and Tang J.B. Digital oedema, adhesion formation and resistance to digital motion after primary flexor tendon repair. J Hand Surg 33E (2008) 745-752
26. Chen C.H., Zhou Y.L., Wu Y.F., Cao Y., Gao J.S., and Tang J.B. Effectiveness of microRNA in down regulation of TGF-β gene expression in digital flexor tendons of chickens: in vitro and in vivo study. J Hand Surg 34E (2009) 1777-1784
27. Losa M., Barzaghi R.L., Mortini P., Franzin A., Mangili F., Terreni M.R., et al. Determination of the proliferation and apoptotic index in adrenocorticotropin-secreting pituitary tumors: comparison between micro- and macroadenomas. Am J Pathol 156 (2000) 245-251
28. Tanaka F., Kawano Y., Li M., Takata T., Miyahara R., Yanagihara K., et al. Prognostic significance of apoptotic index in completely resected non-small-cell lung cancer. J Clin Oncol 17 (1999) 2728-2736
29. Rai N.K., Suryabhan, Ansari M., Kumar M., Shukla V.K., and Tripathi K. Effect of glycaemic control on apoptosis in diabetic wounds. J Wound Care 14 (2005) 277-281
30. Prosperi E. Multiple roles of the proliferating cell nuclear antigen: DNA replication, repair and cell cycle control. Prog Cell Cycle Res 3 (1997) 193-210
31. Berglund M., Hart D.A., and Wiig M. The inflammatory response and hyaluronan synthases in the rabbit flexor tendon and tendon sheath following injury. J Hand Surg 32E (2007) 581-587
32. Boyer M.I., Watson J.T., Lou J., Manske P.R., Gelberman R.H., and Cai S.R. Quantitative variation in vascular endothelial growth factor mRNA expression during early flexor tendon healing: an investigation in a canine model. J Orthop Res 19 (2001) 869-872
33. Gelberman R.H., Amiel D., and Harwood F. Genetic expression for type I procollagen in the early stages of flexor tendon healing. J Hand Surg 17A (1992) 551-558
34. Morley N., Rapp A., Dittmar H., Salter L., Gould D., Greulich K.O., et al. UVA-induced apoptosis studied by the new apo/necro-Comet-assay which distinguishes viable, apoptotic and necrotic cells. Mutagenesis 21 (2006) 105-114
35. Garrity M.M., Burgart L.J., Riehle D.L., Hill E.M., Sebo T.J., and Witzig T. Identifying and quantifying apoptosis: navigating technical pitfalls. Mod Pathol 16 (2003) 389-394