SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Pan, Chi Jiunn ^a   Chen, Shih Yin ^a   Jun, Hyun Sik ^a   Lin, Su Ru ^a   Mansfield, Brian C ^a   Chou, Janice Y ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROGENIC ACID; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUCOSE 6 PHOSPHATASE ALPHA; GLUCOSE 6 PHOSPHATASE BETA; GLUCOSE 6 PHOSPHATE; GLUCOSE 6 PHOSPHATE ANTIPORTER; MEMBRANE PROTEIN; SLC37A1 PROTEIN; SLC37A2 PROTEIN; SLC37A3 PROTEIN; SLC37A4 PROTEIN; UNCLASSIFIED DRUG; ANTIPORTER; CARRIER PROTEIN; GLUCOSE 6 PHOSPHATE(TRANSPORTER); GLUCOSE 6-PHOSPHATE(TRANSPORTER); GLUCOSE TRANSPORTER; PHOSPHATE; PROTEOLIPID; PROTEOLIPOSOMES; SLC37A1 PROTEIN, HUMAN; SLC37A2 PROTEIN, HUMAN;

ANIMAL TISSUE; ARTICLE; CELL STRAIN COS1; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE EXPRESSION; GLUCOSE HOMEOSTASIS; HYDROLYSIS; INTESTINE; KIDNEY; LIVER; MOUSE; NONHUMAN; PANCREAS; PHOSPHATE TRANSPORT; ANIMAL; CERCOPITHECUS; FLUORESCENCE MICROSCOPY; GENE EXPRESSION PROFILING; GENETICS; HUMAN; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSPORT AT THE CELLULAR LEVEL; WESTERN BLOTTING;

ANIMALS; ANTIPORTERS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CERCOPITHECUS AETHIOPS; COS CELLS; ENDOPLASMIC RETICULUM; GENE EXPRESSION PROFILING; GLUCOSE; GLUCOSE-6-PHOSPHATE; HUMANS; INTESTINES; KIDNEY; LIVER; MEMBRANE TRANSPORT PROTEINS; MICE; MICROSCOPY, FLUORESCENCE; MONOSACCHARIDE TRANSPORT PROTEINS; PANCREAS; PHOSPHATES; PROTEOLIPIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 80052960191     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023157     Document Type: Article

References (33)

1. Pan C-J, Lin B, Chou JY, (1999) Transmembrane topology of human Glucose-6-phosphate transporter. J Biol Chem 274: 13865-13869.
2. Pan CJ, Chen SY, Lee S, Chou JY, (2009) Structure-function study of glucose-6-phosphate transporter, an eukaryotic antiporter deficient in glycogen storage disease type Ib. Mol Genet Metab 96: 32-37.
3. Chen SY, Pan CJ, Nandigama K, Mansfield BC, Ambudkar SV, et al. (2008) The Glucose-6-phosphate transporter is a phosphate-linked antiporter deficient in glycogen storage disease type Ib and Ic. FASEB J 22: 2206-2213.
4. Ghosh A, Shieh J-J, Pan C-J, Sun M-S, Chou JY, (2002) The catalytic center of glucose-6-phosphatase: His176 is the nucleophile forming the phosphohistidine-enzyme intermediate during catalysis. J Biol Chem 277: 32837-32842.
5. Chou JY, Matern D, Mansfield BC, Chen Y-T, (2002) Type I glycogen storage diseases: disorders of the glucose-6-phosphatase complex. Curr Mol Med 2: 121-143.
6. Chou JY, Jun HS, Mansfield BC, (2010) Glycogen storage disease type I and G6Pase-β deficiency: etiology and therapy. Nat Rev Endocrinol 6: 676-688.
7. Arion WJ, Canfield WK, Ramos FC, Schindler PW, Burger HJ, et al. (1997) Chlorogenic acid and hydroxynitrobenzaldehyde: new inhibitors of hepatic glucose 6-phosphatase. Arch Biochem Biophys 339: 315-322.
8. Lei K-J, Chen H, Pan C-J, Ward JM, Mosinger B, et al. (1996) Glucose-6-phosphatase dependent substrate transport in the glycogen storage disease type 1a mouse. Nat Genet 13: 203-209.
9. Zingone A, Hiraiwa H, Pan C-J, Lin B, Chen H, et al. (2000) Correction of glycogen storage disease type 1a in a mouse model by gene therapy. J Biol Chem 275: 828-832.
10. Hiraiwa H, Pan C-J, Lin B, Moses SW, Chou JY, (1999) Inactivation of the glucose-6-phosphate transporter causes glycogen storage disease type 1b. J Biol Chem 274: 5532-5536.
11. Chen L-Y, Lin B, Pan C-J, Hiraiwa H, Chou JY, (2000) Structural requirements for the stability and microsomal transport activity of the human glucose-6-phosphate transporter. J Biol Chem 275: 34280-34286.
12. Chen L-Y, Pan C-J, Shieh J-J, Chou JY, (2002) Structure-function analysis of the glucose-6-phosphate transporter deficient in glycogen storage disease type Ib. Hum Mol Genet 11: 3199-3207.
13. Bartoloni L, Wattenhofer M, Kudoh J, Berry A, Shibuya K, et al. (2000) Cloning and characterization of a putative human glycerol 3-phosphate permease gene (SLC37A1 or G3PP) on 21q22.3: mutation analysis in two candidate phenotypes, DFNB10 and a glycerol kinase deficiency. Genomics 70: 190-200.
14. Iacopetta D, Lappano R, Cappello AR, Madeo M, De Francesco EM, et al. (2010) SLC37A1 gene expression is up-regulated by epidermal growth factor in breast cancer cells. Breast Cancer Res Treat 122: 755-764.
15. Bartoloni L, Antonarakis SE, (2004) The human sugar-phosphate/phosphate exchanger family SLC37. Pflugers Arch 447: 780-783.
16. Takahashi Y, Miyata M, Zheng P, Imazato T, Horwitz A, et al. (2000) Identification of cAMP analogue inducible genes in RAW264 macrophages. Biochim Biophys Acta 1492: 385-394.
17. Kim JY, Tillison K, Zhou S, Wu Y, Smas CM, (2007) The major facilitator superfamily member Slc37a2 is a novel macrophage- specific gene selectively expressed in obese white adipose tissue. Am J Physiol Endocrinol Metab 293: E110-E20.
18. Leuzzi R, Fulceri R, Marcolongo P, Bánhegyi G, Zammarchi E, et al. (2001) Glucose 6-phosphate transport in fibroblast microsomes from glycogen storage disease type 1b patients: evidence for multiple glucose 6-phosphate transport systems. Biochem J 357: 557-562.
19. Hardy S, Kitamura M, Harris-Stansil T, Dai Y, Phipps ML, (1997) Construction of adenovirus vectors through Cre-lox recombination. J Virol 71: 1842-1849.
20. Shieh J-J, Pan C-J, Mansfield BC, Chou JY, (2003) Glucose-6-phosphate hydrolase, widely expressed outside the liver, can explain age-dependent resolution of hypoglycemia in glycogen storage disease type Ia. J Biol Chem 278: 47098-47103.
21. Ambudkar SV, Larson TJ, Maloney PC, (1986) Reconstitution of sugar phosphate transport systems of Escherichia coli. J Biol Chem 261: 9083-9086.
22. Sonna LA, Ambudkar SV, Maloney PC, (1988) The mechanism of glucose 6-phosphate transport by Escherichia coli. J Biol Chem 263: 6625-6630.
23. Maloney PC, Ambudkar SV, (1989) The functional reconstitution of prokaryote and eukaryote membrane proteins. Arch Biochem Biophys 269: 1-10.
24. Schaffner W, Weissmann C, (1973) A rapid, sensitive, and specific method for the determination of protein in dilute solution. Anal Biochem 56: 502-514.
25. Ambudkar SV, Zlotnick GW, Rosen BP, (1984) Calcium efflux from Escherichia coli. Evidence for two systems. J Biol Chem 259: 6142-6146.
26. Singh J, Nordlie RC, Jorgenson RA, (1981) Vanadate: a potent inhibitor of multifunctional glucose-6-phosphatase. Biochim Biophys Acta 678: 477-482.
27. Michalak M, Groenendyk J, Szabo E, Gold LI, Opas M, (2009) Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum. Biochem J 417: 651-666.
28. Mithieux G, Rajas F, Gautier-Stein A, (2004) A novel role for glucose 6-phosphatase in the small intestine in the control of glucose homeostasis. J Biol Chem 279: 44231-44234.
29. Brunner Y, Schvartz D, Priego-Capote F, Couté Y, Sanchez JC, (2009) Glucotoxicity and pancreatic proteomics. J Proteomics 71: 576-591.
30. He L, Vasiliou K, Nebert DW, (2009) Analysis and update of the human solute carrier (SLC) gene superfamily. Hum Genomics 3: 195-206.
31. Gerin I, Veiga-da-Cunha M, Achouri Y, Collet JF, Van Schaftingen E, (1997) Sequence of a putative glucose-6-phosphate translocase, mutated in glycogen storage disease type 1b. FEBS Lett 419: 235-238.
32. Annabi B, Hiraiwa H, Mansfield BC, Lei K-J, Ubagai T, et al. (1998) The gene for glycogen storage disease type 1b maps to chromosome 11q23. Am J Hum Genet 62: 400-405.
33. Melis D, Fulceri R, Parenti G, Marcolongo P, Gatti R, et al. (2005) Genotype/phenotype correlation in glycogen storage disease type 1b: a multicentre study and review of the literature. Eur J Pediatr 164: 501-508.