Pro: Genome-wide association studies (GWAS) in asthma

American Journal of Respiratory and Critical Care Medicine

Volumn 184, Issue 6, 2011, Pages 631-633

  Weiss, Scott T ^a   Silverman, Edwin K ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GENOMIC DNA; HIGH DENSITY LIPOPROTEIN; HLA DQ ANTIGEN; IMMUNOGLOBULIN E; INTERLEUKIN 33; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ASTHMA; AUTOPHAGY; CELIAC DISEASE; CROHN DISEASE; CYTOGENETICS; DNA METHYLATION; DNA SEQUENCE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; META ANALYSIS (TOPIC); NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PSORIASIS; RETINA MACULA AGE RELATED DEGENERATION; REVIEW; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; ASTHMA; DISEASE MODELS, ANIMAL; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; RESEARCH DESIGN;

EID: 80052942433     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201103-0485ED     Document Type: Review

References (18)

1. Clamp M, Fry B, Kamal M, Xie X, Cuff J, Lin MF, Kellis M, Lindblad-Toh K, Lander ES. Distinguishing protein-coding and noncoding genes in the human genome. Proc Natl Acad Sci USA 2007;104:19428-19433.
2. Lander E. Initial impact of the sequencing of the human genome. Nature 2011;470:187-197.
3. Lander E. The new genomics: global views of biology. Science 1996;274:536-539. (Pubitemid 26360427)
4. Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science 1996;273:1516-1517. (Pubitemid 26301653)
5. Teslovich T, Musunuru K, Smith A, Edmondson A. Stylianou Iea. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010;466:707-712.
6. Franke A, McGovern D, Barrett J, Wang K. R-SGe. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 2010;42:1118-1125.
7. Voight BF, Scott L, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010;42:579-589.
8. Moffatt MG, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, von Mutius E, Farrall M, Lathrop M, Cookson WO. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 2010;363:1211-1221.
9. Himes B, Hunninghake G, Baurley JW, Rafaels NM, Sleiman P, Strachan DP, Wilk JB, Willis-Owen SA, Klanderman B, Lasky-Su J, et al. Genome-wide association analysis identified PDE4D as an asthma-susceptibility gene. Am J Hum Genet 2009;84:581-593.
10. Ferreira M, McRae A, Medland S, Nyholt DR, Gordon SD, Wright MJ, Henders AK, Madden PA, Visscher PM, Wray NR, et al. Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia. Eur J Hum Genet 2011;19:458-464.
11. Li X, Howard T, Zheng S, Haselkorn T, Peters SP, Meyers DA, Bleecker ER. Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. J Allergy Clin Immunol 2010;125:328-335.
12. DeWan A, Triche E, Xu X, Hsu LI, Zhao C, Belanger K, Hellenbrand K, Willis-Owen SA, Moffatt M, Cookson WO, et al. PDE11A associations with asthma: results of a genome-wide association scan. J Allergy Clin Immunol 2010;126:871-873.
13. Mathias R, Grant A, Rafaels N, Hand T, Gao L, Vergara C, Tsai Y, Yang M, Campbell M, Foster C, et al. A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol 2010;125:336-346.
14. Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, Depner M, von Berg A, Bufe A, Rietschel E, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007;448:470-473.
15. Hardy J, Singleton A. Genome wide association studies and human disease. N Engl J Med 2009;360:1759-1768.
16. Sleiman PM, Flory J, Imielinski M, Bradfield JP, Annaiah K, Wilis-Owen SA, Wang K, Rafaels NM, Michel S, Bonnelykke K, et al. Variants of DENND1B associated with asthma in children. N Engl J Med 2010;362:36-44.
17. Hancock DB, Romieu I, Shi M, Sienra-Monge JJ, Wu H, Chiu GY, Li H, del Rio-Navarro BE, Willis-Owen SA, Weiss ST, et al. Genomewide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in Mexican children. PLoS Genet 2009;5:e1000623.
18. Choudhry S, Taub M, Mei R, Rodriguez-Santana J, Rodriguez-Cintron W, Shriver MD, Ziv E, Risch NJ, Burchard EG. Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 region. Hum Genet 2008;123:455-468.