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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 20, 2011, Pages 6074-6080

Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors

(6) Abdur Rahim, M a Praveen Rao, P N b Bhardwaj, Atul a Kaur, Jatinder a Huang, Zhangjian a Knaus, Edward E a

a UNIVERSITY OF ALBERTA (Canada)

b UNIVERSITY OF WATERLOO (Canada)

Author keywords

Acetoxy regioisomers; Anti inflammatory activity; Celecoxib; Cyclooxygenase 1 and 2 inhibition; Molecular modeling

Indexed keywords

1 (4 AMINOSULFONYLPHENYL) 3 TRIFLUOROMETHYL 5 (2 ACETOXY 4 FLUOROPHENYL)PYRAZOLE; ACETYLSALICYLIC ACID; CELECOXIB; CELECOXIB DERIVATIVE; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; HISTIDINE; IBUPROFEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; EVALUATION; HYDROGEN BOND; IC 50; ISOMER; MOLECULAR MODEL; NONHUMAN; PAW EDEMA; RAT; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CATALYTIC DOMAIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; HUMANS; MODELS, MOLECULAR; PYRAZOLES; RATS; SULFONAMIDES;

EID: 80052940694 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.08.053 Document Type: Article

Times cited : (12)

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