Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3

Journal of General Virology

Volumn 92, Issue 10, 2011, Pages 2394-2398

  Mutocheluh, M ^a   Hindle, L ^a   Areste C ^a,e   Chanas, S A ^a   Butler, L M ^a,b   Lowry, K ^c   Shah, K ^d   Evans, D J ^c   Blackbourn, D J ^a,b  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY OF WARWICK   (United Kingdom)

^d MOORFIELDS EYE HOSPITAL   (United Kingdom)

^e BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; INTERFERON REGULATORY FACTOR 2; INTERFERON REGULATORY FACTOR 9; INTERFERON STIMULATED GENE FACTOR 3; STAT1 PROTEIN;

ARTICLE; CONTROLLED STUDY; ENCEPHALOMYOCARDITIS VIRUS; GEL MOBILITY SHIFT ASSAY; HUMAN HERPESVIRUS 8; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VIRUS REPLICATION; WESTERN BLOTTING;

BLOTTING, WESTERN; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENCEPHALOMYOCARDITIS VIRUS; HERPESVIRUS 8, HUMAN; IMMUNE EVASION; INTERFERON REGULATORY FACTORS; INTERFERON TYPE I; INTERFERON-STIMULATED GENE FACTOR 3, GAMMA SUBUNIT; STAT1 TRANSCRIPTION FACTOR; VIRAL PROTEINS; VIRUS REPLICATION;

ENCEPHALOMYOCARDITIS VIRUS; HUMAN HERPESVIRUS 8;

EID: 80052933223     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.034322-0     Document Type: Article

References (21)

1. Aresté, C. & Blackbourn, D. J. (2009). Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus. Trends Microbiol 17, 119-129.
2. Aresté, C., Mutocheluh, M. & Blackbourn, D. J. (2009). Identification of caspase-mediated decay of interferon regulatory factor-3, exploited by a Kaposi sarcoma-associated herpesvirus immunoregulatory protein. J Biol Chem 284, 23272-23285.
3. Bouvard, V., Baan, R., Straif, K., Grosse, Y., Secretan, B., El Ghissassi, F., Benbrahim-Tallaa, L., Guha, N., Freeman, C. & other authors (2009). A review of human carcinogens - part B: biological agents. Lancet Oncol 10, 321-322.
4. Burýsek, L. & Pitha, P. M. (2001). Latently expressed human herpesvirus 8-encoded interferon regulatory factor 2 inhibits double-stranded RNA-activated protein kinase. J Virol 75, 2345-2352.
5. Burysek, L., Yeow, W. S. & Pitha, P. M. (1999). Unique properties of a second human herpesvirus 8-encoded interferon regulatory factor (vIRF-2). J Hum Virol 2, 19-32.
6. Chang, Y., Cesarman, E., Pessin, M. S., Lee, F., Culpepper, J., Knowles, D. M. & Moore, P. S. (1994). Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266, 1865-1869.
7. Chatterjee, M., Osborne, J., Bestetti, G., Chang, Y. & Moore, P. S. (2002). Viral IL-6-induced cell proliferation and immune evasion of interferon activity. Science 298, 1432-1435.
8. Cunningham, C., Barnard, S., Blackbourn, D. J. & Davison, A. J. (2003). Transcription mapping of human herpesvirus 8 genes encoding viral interferon regulatory factors. J Gen Virol 84, 1471-1483.
9. Fuld, S., Cunningham, C., Klucher, K., Davison, A. J. & Blackbourn, D. J. (2006). Inhibition of interferon signaling by the Kaposi's sarcoma-associated herpesvirus full-length viral interferon regulatory factor 2 protein. J Virol 80, 3092-3097.
10. Gao, S. J., Boshoff, C., Jayachandra, S., Weiss, R. A., Chang, Y. & Moore, P. S. (1997). KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway. Oncogene 15, 1979-1985.
11. Gauzzi, M. C, Velazquez, L., McKendry, R., Mogensen, K.E., Fellous, M. & Pellegrini, S. (1996). Interferon-a-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. J Biol Chem 271, 20494-20500.
12. Krishnan, H. H., Naranatt, P. P., Smith, M. S., Zeng, L., Bloomer, C. & Chandran, B. (2004). Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent decline of lytic gene expression. J Virol 78, 3601-3620.
13. Li, M., Damania, B., Alvarez, X., Ogryzko, V., Ozato, K. & Jung, J. U. (2000). Inhibition of p300 histone acetyltransferase by viral interferon regulatory factor. Mol Cell Biol 20, 8254-8263.
14. Lubyova, B. & Pitha, P. M. (2000). Characterization of a novel human herpesvirus 8-encoded protein, vIRF-3, that shows homology to viral and cellular interferon regulatory factors. J Virol 74, 8194-8201.
15. Morrison, J. M. & Racaniello, V. R. (2009). Proteinase 2Apro is essential for enterovirus replication in type I interferon-treated cells. J Virol 83, 4412-4422.
16. Randall, R. E. & Goodbourn, S. (2008). Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J Gen Virol 89, 1-47.
17. Rezaee, S. A., Cunningham, C., Davison, A. J. & Blackbourn, D. J. (2006). Kaposi's sarcoma-associated herpesvirus immune modulation: an overview. J Gen Virol 87, 1781-1804.
18. Schmidt, K., Wies, E. & Neipel, F. (2011). Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 3 inhibits gamma interferon and major histocompatibility complex class II expression. J Virol 85, 4530-4537.
19. Shin, Y. C., Nakamura, H., Liang, X., Feng, P., Chang, H., Kowalik, T. F. & Jung, J. U. (2006). Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1. J Virol 80, 2257-2266.
20. Wies, E., Hahn, A. S., Schmidt, K., Viebahn, C., Rohland, N., Lux, A., Schellhorn, T., Holzer, A., Jung, J. U. & Neipel, F. (2009). The Kaposi's sarcoma-associated herpesvirus-encoded vIRF-3 inhibits cellular IRF-5. J Biol Chem 284, 8525-8538.
21. Zimring, J. C., Goodbourn, S. & Offermann, M. K. (1998). Human herpesvirus 8 encodes an interferon regulatory factor (IRF) homolog that represses IRF-1-mediated transcription. J Virol 72, 701-707.