Synthesis and anticancer activity studies of novel 1-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)uracil and (6′-substituted)-7- or 9-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-7H- or 9H-purines

Tetrahedron

Volumn 62, Issue 50, 2006, Pages 11724-11733

  Núñez, María C ^a   Pavani, Maria G ^a   Díaz Gavilán, Mónica ^a   Rodríguez Serrano, Fernando ^b   Gómez Vidal, José A ^a   Marchal, Juan A ^b   Aránega, Antonia ^c   Gallo, Miguel A ^a   Espinosa, Antonio ^a   Campos, Joaquín M ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b Facultad de CC Experimentales   (Spain)

^c UNIVERSITY OF GRANADA   (Spain)

Author keywords

Amination; Antitumour compounds; Benzodioxepins; Suzuki reaction; Trifluoromethylation reaction

Indexed keywords

1 (2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN 3 YL) 5 FLUOROURACIL; 1 (2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN 3 YL)URACIL; 2,6 DICHLORO 7 (2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN 3 YL) 7H PURINE; 2,6 DICHLORO 9 (2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN 3 YL) 9H PURINE; 6 CHLORO 7 (2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN 3 YL) 7H PURINE; 6 CHLORO 9 (2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN 3 YL) 9H PURINE; 6 IODO 7 (2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN 3 YL) 7H PURINE; 6 IODO 9 (2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN 3 YL) 9H PURINE; 6 PHENYL 7 (2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN 3 YL) 7H PURINE; 6 PHENYL 9 (2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN 3 YL) 9H PURINE; 6 TRIFLUOROMETHYL 7 (2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN 3 YL) 7H PURINE; 6 TRIFLUOROMETHYL 9 (2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN 3 YL) 9H PURINE; 7 (2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN 3 YL) 7H ADENINE; 7 (2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN 3 YL) 7H N,N DIMETHYLADENINE; 7 (2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN 3 YL) 7H PURINE; 9 (2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN 3 YL) 9H ADENINE; 9 (2,3 DIHYDRO 5H 1,4 BENZODIOXEPIN 3 YL) 9H PURINE; ANTINEOPLASTIC AGENT; PURINE DERIVATIVE; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHEMICAL STRUCTURE; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIPOPHILICITY; PRIORITY JOURNAL;

EID: 33750628423     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2006.09.039     Document Type: Article

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