Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-dpyrimidine core

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 20, 2011, Pages 6122-6125

  Dow, Robert L ^a   Andrews, Melissa ^a   Aspnes, Gary E ^a   Balan, Gayatri ^a   Michael Gibbs, E ^a   Guzman Perez, Angel ^a   Karki, Kapil ^a   Laperle, Jennifer L ^a   Li, Jian Cheng ^a   Litchfield, John ^a   Munchhof, Michael J ^a   Perreault, Christian ^a   Patel, Leena ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

DGAT 1; Diabetes; Dioxino 2,3 dpyrimidine; Inhibition; Obesity; Triglycerides

Indexed keywords

ACYLTRANSFERASE INHIBITOR; DIACYLGLYCEROL ACYLTRANSFERASE; DIOXINO[2,3 D]PYRIMIDINE; PF 04620110; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; PHARMACOPHORE; STEREOCHEMISTRY;

ANIMALS; DIACYLGLYCEROL O-ACYLTRANSFERASE; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MICE; MODELS, MOLECULAR; PYRIMIDINES; TRIGLYCERIDES;

EID: 80052924403     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.08.028     Document Type: Article

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