메뉴 건너뛰기




Volumn 7, Issue 4, 2011, Pages 578-589

Sub acute toxicity assessment of glipizide engineered polymeric nanoparticles

Author keywords

Diabetic therapy; Glipizide; Haemolysis; Polymeric nanoparticle; Toxicity

Indexed keywords

ACUTE TOXICITY; DIABETIC THERAPY; DRUG ADMINISTRATION; GLIPIZIDE; HAEMATOLOGY; HAEMOLYSIS; HISTOPATHOLOGICAL EXAMINATIONS; IN-VITRO; METHYL METHACRYLATES; NORMAL CONTROLS; ORAL ADMINISTRATION; ORAL ROUTE; PATIENT COMFORT; POLYMERIC NANOPARTICLES; SHELF LIFE; TOXIC EFFECT;

EID: 80052914832     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2011.1317     Document Type: Article
Times cited : (21)

References (56)
  • 1
    • 0042697522 scopus 로고    scopus 로고
    • Advances in drug delivery of oral hypoglycemic agents
    • G. Kadhe and R. E. Arasan, Advances in drug delivery of oral hypoglycemic agents. Curr. Sci. 83, 1539 (2002).
    • (2002) Curr. Sci. , vol.83 , pp. 1539
    • Kadhe, G.1    Arasan, R.E.2
  • 2
    • 0018697041 scopus 로고
    • Glipizide: A review of its pharmacological properties and therapeutic properties
    • R. N. Brogden, R. C. Heel, and G. E. Pakes, Glipizide: A review of its pharmacological properties and therapeutic properties. Drugs. 18, 329 (1979).
    • (1979) Drugs , vol.18 , pp. 329
    • Brogden, R.N.1    Heel, R.C.2    Pakes, G.E.3
  • 4
    • 77954070289 scopus 로고    scopus 로고
    • Exposure, uptake, distribution and toxicity of nanomaterials
    • T. S. Holgate, Exposure, uptake, distribution and toxicity of nanomaterials. J. Biomed. Nanotechnol. 6, 1 (2010).
    • (2010) J. Biomed. Nanotechnol. , vol.6 , pp. 1
    • Holgate, T.S.1
  • 5
    • 44749085632 scopus 로고    scopus 로고
    • Nanomedicine a new approach for the treatment of serious diseases
    • C. Vauthier and P. Couvreur, Nanomedicine a new approach for the treatment of serious diseases. J. Biomed. Nanotechnol. 3, 223 (2007).
    • (2007) J. Biomed. Nanotechnol. , vol.3 , pp. 223
    • Vauthier, C.1    Couvreur, P.2
  • 6
    • 1542726626 scopus 로고    scopus 로고
    • Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation
    • C. W. Lam, J. T. James, R. Mc Cluskey, and R. L. Hunter, Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol. Sci. 77, 126 (2004).
    • (2004) Toxicol. Sci. , vol.77 , pp. 126
    • Lam, C.W.1    James, J.T.2    Mc Cluskey, R.3    Hunter, R.L.4
  • 7
    • 79957720810 scopus 로고    scopus 로고
    • Toxicity Assessment of Engineered Nanomaterials: Resolving the Challenges
    • A. Dhawan, A. Pandey, and V. Sharma, Toxicity Assessment of Engineered Nanomaterials: Resolving the Challenges. J. Biomed. Nanotechnol. 7, 6 (2011).
    • (2011) J. Biomed. Nanotechnol. , vol.7 , pp. 6
    • Dhawan, A.1    Pandey, A.2    Sharma, V.3
  • 8
    • 20644449754 scopus 로고    scopus 로고
    • Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles
    • E. Oberdorster and J. Oberdorster, Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 113, 823 (2005).
    • (2005) Environ. Health Perspect. , vol.113 , pp. 823
    • Oberdorster, E.1    Oberdorster, J.2
  • 11
    • 36148942678 scopus 로고    scopus 로고
    • Dependence of nanotoxicity on nanoscale characteristics and strategies for reducing and eliminating nanotoxicity
    • edited by Y. L. Zhao and H. S. Nalwa, American Scientific Publishers, California
    • Y. L. Zhao, H. Meng, Z. Chen, F. Zhao, and Z. F. Chai, Dependence of nanotoxicity on nanoscale characteristics and strategies for reducing and eliminating nanotoxicity, Nanotoxicology, edited by Y. L. Zhao and H. S. Nalwa, American Scientific Publishers, California (2007), pp. 265-280.
    • (2007) Nanotoxicology , pp. 265-280
    • Zhao, Y.L.1    Meng, H.2    Chen, Z.3    Zhao, F.4    Chai, Z.F.5
  • 12
    • 0035206137 scopus 로고    scopus 로고
    • Gastro intestinal per sorption and tissue distribution of differently sized colloidal gold nanoparticles
    • J. F. Hillye and R. M. Abrecht, Gastro intestinal per sorption and tissue distribution of differently sized colloidal gold nanoparticles. J. Pharm. Sci. 90, 1927 (2001).
    • (2001) J. Pharm. Sci. , vol.90 , pp. 1927
    • Hillye, J.F.1    Abrecht, R.M.2
  • 13
    • 0029001869 scopus 로고
    • A commentary on morphological and quantitative aspects of micro particle translocation across the gastro intestinal mucosa
    • G. M. Hodges, E. A. Carr, R. A Hazzard, O. Roilly, and K. E. Carr, A commentary on morphological and quantitative aspects of micro particle translocation across the gastro intestinal mucosa. J. Drug Target. 3, 57 (1995).
    • (1995) J. Drug Target. , vol.3 , pp. 57
    • Hodges, G.M.1    Carr, E.A.2    Hazzard, R.A.3    Roilly, O.4    Carr, K.E.5
  • 14
    • 0032101141 scopus 로고    scopus 로고
    • Ultrafine (nanometer) particle mediated lung injury
    • K. Donaldson, X. Y. Li, and N. W. Mac, Ultrafine (nanometer) particle mediated lung injury. J. Aerosol Sci. 29, 553 (1998).
    • (1998) J. Aerosol Sci. , vol.29 , pp. 553
    • Donaldson, K.1    Li, X.Y.2    Mac, N.W.3
  • 15
    • 79953141208 scopus 로고    scopus 로고
    • Focus on skin as a possible port of entry for solid nanoparticles and the toxicological impact
    • T. G. M. Smijs and J. A. Bouwstra, Focus on skin as a possible port of entry for solid nanoparticles and the toxicological impact. J. Biomed. Nanotechnol. 6, 469 (2010).
    • (2010) J. Biomed. Nanotechnol. , vol.6 , pp. 469
    • Smijs, T.G.M.1    Bouwstra, J.A.2
  • 16
    • 79953157075 scopus 로고    scopus 로고
    • Skin absorption and potential toxicity of nanoparticulate nanomaterials
    • B. Baroli, Skin absorption and potential toxicity of nanoparticulate nanomaterials. J. Biomed. Nanotechnol. 6, 485 (2010).
    • (2010) J. Biomed. Nanotechnol. , vol.6 , pp. 485
    • Baroli, B.1
  • 17
    • 67649386621 scopus 로고    scopus 로고
    • Nanocytotoxicity: Violacein and violacein-loaded poly(D,L-lactide-co- glycolide) nanoparticles acting on human leukemic cells
    • P. S. Melo, M. M. M. De Azevedo, L. Frungillo, M. C. Anazetti, P. D. Marcato, and N. Durán, Nanocytotoxicity: Violacein and violacein-loaded poly(D,L-lactide-co-glycolide) nanoparticles acting on human leukemic cells. J. Biomed. Nanotechnol. 5, 192 (2009).
    • (2009) J. Biomed. Nanotechnol. , vol.5 , pp. 192
    • Melo, P.S.1    De Azevedo, M.M.M.2    Frungillo, L.3    Anazetti, M.C.4    Marcato, P.D.5    Durán, N.6
  • 18
    • 79957744401 scopus 로고    scopus 로고
    • Immunopotentiating role of encapsulated proteins of infectious diseases in biopolymeric nanoparticles as a potential delivery system
    • A. K. Verma, R. P. Pandey, A. Chanchal, and P. Sharma, Immunopotentiating role of encapsulated proteins of infectious diseases in biopolymeric nanoparticles as a potential delivery system. J. Biomed. Nanotechnol. 7, 63 (2011).
    • (2011) J. Biomed. Nanotechnol. , vol.7 , pp. 63
    • Verma, A.K.1    Pandey, R.P.2    Chanchal, A.3    Sharma, P.4
  • 19
    • 0028349560 scopus 로고
    • A novel assay to determine the haemolytic activity of drugs incorporated in colloidal carrier systems
    • K. T. Bock and W. B. Muller, A novel assay to determine the haemolytic activity of drugs incorporated in colloidal carrier systems. Pharm. Res. 11, 589 (1994).
    • (1994) Pharm. Res. , vol.11 , pp. 589
    • Bock, K.T.1    Muller, W.B.2
  • 20
    • 0024420103 scopus 로고
    • A comparison of in-vitro toxicity and antifungal efficacy of membrane active drugs after liposome encapsulation
    • R. T. Mehta, R. L. Hopfer, R. L. Juliano, and G. Lopoz-Berestein, A comparison of in-vitro toxicity and antifungal efficacy of membrane active drugs after liposome encapsulation. Select Cancer Ther. 5, 113 (1989).
    • (1989) Select Cancer Ther. , vol.5 , pp. 113
    • Mehta, R.T.1    Hopfer, R.L.2    Juliano, R.L.3    Lopoz-Berestein, G.4
  • 21
    • 0023920068 scopus 로고
    • Toxicity of solubilised and colloidal amphotericin B formulation to human erythrocytes
    • D. Forster, C. Washington, and S. S. Davis, Toxicity of solubilised and colloidal amphotericin B formulation to human erythrocytes. J. Pharm. Pharmacol. 40, 325 (1988).
    • (1988) J. Pharm. Pharmacol. , vol.40 , pp. 325
    • Forster, D.1    Washington, C.2    Davis, S.S.3
  • 22
    • 0036903062 scopus 로고    scopus 로고
    • Mutagenicity and in vivo toxicity of combined particulate and semi volatile organic fractions of gasoline and diesel engine emissions
    • J. C. Seagrave, J. D. Mc Donald, A. P. Giglotti, K. J. Nikula, S. K. Seikop, M. Gurevich, and J. L. Mauderly, Mutagenicity and in vivo toxicity of combined particulate and semi volatile organic fractions of gasoline and diesel engine emissions. Toxicol. Sci. 70, 212 (2002).
    • (2002) Toxicol. Sci. , vol.70 , pp. 212
    • Seagrave, J.C.1    Mc Donald, J.D.2    Giglotti, A.P.3    Nikula, K.J.4    Seikop, S.K.5    Gurevich, M.6    Mauderly, J.L.7
  • 24
    • 34347234840 scopus 로고    scopus 로고
    • Assessing toxicity of fine and nanoparticles: Comparing in vitro measurements to in vivo pulmonary toxicity profiles
    • M. C. Sayes, L. K. Reed, and B. D. Warheit, Assessing toxicity of fine and nanoparticles: Comparing in vitro measurements to in vivo pulmonary toxicity profiles. Toxicol. Sci. 97, 163 (2007).
    • (2007) Toxicol. Sci. , vol.97 , pp. 163
    • Sayes, M.C.1    Reed, L.K.2    Warheit, B.D.3
  • 25
    • 0035103773 scopus 로고    scopus 로고
    • In vitro haemolysis of human erythrocytes by plant extracts with antiplasmodic activity
    • P. Sharma and J. D. Sharma, In vitro haemolysis of human erythrocytes by plant extracts with antiplasmodic activity. J . Ethnopharmacol. 74, 239 (2001).
    • (2001) J. Ethnopharmacol. , vol.74 , pp. 239
    • Sharma, P.1    Sharma, J.D.2
  • 26
    • 79952109269 scopus 로고    scopus 로고
    • Nanotechnology and nanomaterials: Toxicology, risk assessment, and regulations
    • A. M. Fan and G. Alexeeff, Nanotechnology and nanomaterials: Toxicology, risk assessment, and regulations. J. Nanosci. Nanotechnol. 10, 8646 (2010).
    • (2010) J. Nanosci. Nanotechnol. , vol.10 , pp. 8646
    • Fan, A.M.1    Alexeeff, G.2
  • 27
    • 0343683341 scopus 로고    scopus 로고
    • Preparation of microspheres by the solvent evaporation technique
    • B. Patrick, O. Donnell, W. James, and Mc Ginity, Preparation of microspheres by the solvent evaporation technique. Adv. Drug. Deliver. Rev. 28, 25 (1997).
    • (1997) Adv. Drug. Deliver. Rev. , vol.28 , pp. 25
    • Patrick, B.1    Donnell, O.2    James, W.3    Mc Ginity4
  • 28
    • 0032952283 scopus 로고    scopus 로고
    • PLGA nanoparticles prepared by nanoprecipitation: Drug loading and release studies of a water soluble drug
    • T. Govender, S. Stolnik, C. G. Martin, L. Illum, and S. D. Stanley, PLGA nanoparticles prepared by nanoprecipitation: Drug loading and release studies of a water soluble drug. J. Control. Rel. 57, 171 (1999).
    • (1999) J. Control. Rel. , vol.57 , pp. 171
    • Govender, T.1    Stolnik, S.2    Martin, C.G.3    Illum, L.4    Stanley, S.D.5
  • 29
    • 0343683341 scopus 로고    scopus 로고
    • Preparation of microspheres by the solvent evaporation technique
    • J. W. Mc Ginity and P. B. O'Donnell, Preparation of microspheres by the solvent evaporation technique. Adv. Drug. Deliver. Rev. 28, 25 (1997).
    • (1997) Adv. Drug. Deliver. Rev. , vol.28 , pp. 25
    • Mc Ginity, J.W.1    O'Donnell, P.B.2
  • 30
    • 77955058134 scopus 로고    scopus 로고
    • In vitro characterization and in vivo toxicity study of repaglinide loaded poly(methyl methacrylate) nanoparticles
    • U. M. Dhana lekshmi, G. Poovi, Narra Kishore, and P. Neelakanta Reddy, In vitro characterization and in vivo toxicity study of repaglinide loaded poly(methyl methacrylate) nanoparticles. Int. J. Pharm. 396, 194 (2010).
    • (2010) Int. J. Pharm. , vol.396 , pp. 194
    • Dhana Lekshmi, U.M.1    Poovi, G.2    Kishore, N.3    Neelakanta Reddy, P.4
  • 31
    • 0034560173 scopus 로고    scopus 로고
    • Optimization of preparation techniques for poly(lactic acid-co-glycolic acid) nanoparticles
    • Duane T. Birnbaum, Jacequeline D. kosmala, and Lisa Brannon peppas, Optimization of preparation techniques for poly(lactic acid-co-glycolic acid) nanoparticles. J. Nanoparticle Research. 2, 173 (2000).
    • (2000) J. Nanoparticle Research , vol.2 , pp. 173
    • Birnbaum, D.T.1    Kosmala, J.D.2    Peppas, L.B.3
  • 32
    • 0242662545 scopus 로고    scopus 로고
    • A new pH responsive glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs
    • V. Bulmus, M. Woodward, L. Lin, N. Murthy, P. Stayton, and A. Hoffmann, A new pH responsive glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs. J. Control. Rel. 93, 105 (2003).
    • (2003) J. Control. Rel. , vol.93 , pp. 105
    • Bulmus, V.1    Woodward, M.2    Lin, L.3    Murthy, N.4    Stayton, P.5    Hoffmann, A.6
  • 33
    • 0037168963 scopus 로고    scopus 로고
    • Toxicological studies of doxorubicin bound to polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles in healthy rats and rats with intracranial glioblastoma
    • S. E. Gelperina, A. Khalansky, Z. S. Smirnova, A. I. Bobruskin, and S. E. Severin, Toxicological studies of doxorubicin bound to polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles in healthy rats and rats with intracranial glioblastoma. Toxicol. lett. 126, 131 (2002).
    • (2002) Toxicol. Lett. , vol.126 , pp. 131
    • Gelperina, S.E.1    Khalansky, A.2    Smirnova, Z.S.3    Bobruskin, A.I.4    Severin, S.E.5
  • 37
    • 77954043891 scopus 로고    scopus 로고
    • Blood compatibility of poly aminodiamine dendrimers and erythrocyte protections
    • M. Hua Han, J. Clen, J. Wing, and X. T. Wang, Blood compatibility of poly aminodiamine dendrimers and erythrocyte protections. J. Biomed. Nanotechnol. 6, 82 (2010).
    • (2010) J. Biomed. Nanotechnol. , vol.6 , pp. 82
    • Hua Han, M.1    Clen, J.2    Wing, J.3    Wang, X.T.4
  • 38
    • 24944474831 scopus 로고    scopus 로고
    • Calcium silicate based microspheres of repaglinide for gastro retentive floating drug delivery: Preparation and in vitro characterization
    • K. J. Sunil, A. M. Awasthi, N. K. Jain, and G. P. Agarwal, Calcium silicate based microspheres of repaglinide for gastro retentive floating drug delivery: Preparation and in vitro characterization. J. Control. Rel. 107, 300 (2005).
    • (2005) J. Control. Rel. , vol.107 , pp. 300
    • Sunil, K.J.1    Awasthi, A.M.2    Jain, N.K.3    Agarwal, G.P.4
  • 41
    • 0141764820 scopus 로고    scopus 로고
    • Therapeutic and haemolytic evaluation of insitu liposomal preparation containing amphotericin β cyclodextrins
    • K. K. Chakraborthy, Therapeutic and haemolytic evaluation of insitu liposomal preparation containing amphotericin β cyclodextrins. J. Pharm. Pharm. Sci. 6, 231 (2003).
    • (2003) J. Pharm. Pharm. Sci. , vol.6 , pp. 231
    • Chakraborthy, K.K.1
  • 42
    • 0030068508 scopus 로고    scopus 로고
    • Cholesterol independent membrane disruption caused by triterpenoid saponins
    • M. Hu, K. Konoki, and K. Tachibana, Cholesterol independent membrane disruption caused by triterpenoid saponins. Biochim Biophys Acta. 1299, 252 (1996).
    • (1996) Biochim Biophys Acta , vol.1299 , pp. 252
    • Hu, M.1    Konoki, K.2    Tachibana, K.3
  • 43
    • 9644281090 scopus 로고    scopus 로고
    • Physiochemical properties and blood compatibility of a cyclated chitosan nanaoparticles
    • D. W. Lee, K. Powersh, and R. Baney, Physiochemical properties and blood compatibility of a cyclated chitosan nanaoparticles. Carbohyd. Polym. 58, 371 (2004).
    • (2004) Carbohyd. Polym. , vol.58 , pp. 371
    • Lee, D.W.1    Powersh, K.2    Baney, R.3
  • 45
    • 53549096253 scopus 로고    scopus 로고
    • In vitro cytotoxicity, haemolysis assay and bio degradation behavior of biodegradable poly(3 hydroxy butyrate)-polyethylene glycol-poly3-hydroxyl butyrate nanoparticles as potential drug carriers
    • C. Chen, Y. C. Cheng, C. H. Yu, S. W. Chen, M. K. Cheung, and P. H. Yu, In vitro cytotoxicity, haemolysis assay and bio degradation behavior of biodegradable poly(3 hydroxy butyrate)-poly(ethylene glycol-poly(3-hydroxyl butyrate nanoparticles as potential drug carriers, J . Biomed. Mater. Res. A. 290 (2008).
    • (2008) J. Biomed. Mater. Res. A , pp. 290
    • Chen, C.1    Cheng, Y.C.2    Yu, C.H.3    Chen, S.W.4    Cheung, M.K.5    Yu, P.H.6
  • 46
    • 0037199140 scopus 로고    scopus 로고
    • Effect of prolonged vigabatrin treatment on hematological and biochemical parameters in plasma, liver and kidney of Swiss albino mice
    • M. Raza, O. A. Al-Shabanah, T. M. El-Hadiyah, and A. A. Al- Majed, Effect of prolonged vigabatrin treatment on hematological and biochemical parameters in plasma, liver and kidney of Swiss albino mice. Sci. Pharm. 70, 135 (2002).
    • (2002) Sci. Pharm. , vol.70 , pp. 135
    • Raza, M.1    Al-Shabanah, O.A.2    El-Hadiyah, T.M.3    Al- Majed, A.A.4
  • 47
    • 0037107609 scopus 로고    scopus 로고
    • A 90 day oral gavage toxicity study of d-methylphenidate in Sprague-Dawley rats
    • S. Teo, D. Stirling, S. Thomas, A. Hoberman, A. Kiorpes, and V. Khetani, A 90 day oral gavage toxicity study of d-methylphenidate in Sprague-Dawley rats. Toxicol. 179, 183 (2002).
    • (2002) Toxicol. , vol.179 , pp. 183
    • Teo, S.1    Stirling, D.2    Thomas, S.3    Hoberman, A.4    Kiorpes, A.5    Khetani, V.6
  • 49
    • 84857074754 scopus 로고    scopus 로고
    • Haemoglobin loss from erythrocytes in vivo result from spleen facilitated vesiculation
    • F. L. A. Willekens, B. R. K. Stoelwinder, Y. A. M. G. Dopp, H. J. Bos, and J. M. Were, Haemoglobin loss from erythrocytes in vivo result from spleen facilitated vesiculation. Blood 101, 744 (2003).
    • (2003) Blood , vol.101 , pp. 744
    • Willekens, F.L.A.1    Stoelwinder, B.R.K.2    Dopp, Y.A.M.G.3    Bos, H.J.4    Were, J.M.5
  • 50
    • 0031825825 scopus 로고    scopus 로고
    • Subchronic oral toxicity study of aquacoat ECD Ethylcellulose aqueous dispersion in the rat
    • L. A. Kotkoskie and C. Freeman, Subchronic oral toxicity study of aquacoat ECD Ethylcellulose aqueous dispersion in the rat. Food Chemi. Toxicol. 36, 705 (1998).
    • (1998) Food Chemi. Toxicol. , vol.36 , pp. 705
    • Kotkoskie, L.A.1    Freeman, C.2
  • 51
    • 0005555040 scopus 로고
    • Animal Clinical Pathology
    • edited by J. D. Micheal and A. H. Manfred, CRC Press, USA
    • S. L. Barry, Animal Clinical Pathology, edited by J. D. Micheal and A. H. Manfred, CRC Handbook of Toxicology, CRC Press, USA (1995).
    • (1995) CRC Handbook of Toxicology
    • Barry, S.L.1
  • 53
    • 0015472235 scopus 로고
    • Studies on wound healing and repair in pigeon liver II: Histochemical studies during acid and alkaline phosphatese during the process
    • B. Pilo, M. V. Asnani, and R. V. Shah, Studies on wound healing and repair in pigeon liver II: Histochemical studies during acid and alkaline phosphatese during the process. J. Animal. Morphol. Physiol. 19, 205 (1972).
    • (1972) J. Animal. Morphol. Physiol. , vol.19 , pp. 205
    • Pilo, B.1    Asnani, M.V.2    Shah, R.V.3
  • 54
    • 55449085855 scopus 로고    scopus 로고
    • Bio chemical and enzymatic changes after black scorpion Heterometrus fastigious Couzijn envenomation in experimental albino mice
    • M. Kumar Chaubey and R. Kant Upadhyay, Bio chemical and enzymatic changes after black scorpion Heterometrus fastigious Couzijn envenomation in experimental albino mice. J. Appl. Toxicol. 28, 874 (2008).
    • (2008) J. Appl. Toxicol. , vol.28 , pp. 874
    • Kumar Chaubey, M.1    Kant Upadhyay, R.2
  • 55
    • 0031972407 scopus 로고    scopus 로고
    • Toxicological studies on three leaves of avicennia marina in rats
    • B. Ali and A. Basher, Toxicological studies on three leaves of avicennia marina in rats. J. Appl. Toxicol. 18, 111 (1998).
    • (1998) J. Appl. Toxicol. , vol.18 , pp. 111
    • Ali, B.1    Basher, A.2
  • 56
    • 42649143562 scopus 로고    scopus 로고
    • Twenty eight days oral toxicity, Genotoxicity and gender related tissue distribution of silver nanoparticles in Sprague Dawley rats
    • Y. S. Kim, J. Sikkim, H. S. Cho, D. S. Rha, and I. Yu, Twenty eight days oral toxicity, Genotoxicity and gender related tissue distribution of silver nanoparticles in Sprague Dawley rats. Inhal. Toxicol. 20, 575 (2008).
    • (2008) Inhal. Toxicol. , vol.20 , pp. 575
    • Kim, Y.S.1    Sikkim, J.2    Cho, H.S.3    Rha, D.S.4    Yu, I.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.