Mechanism of lidocaine block of late current in long Q-T mutant Na+ channels

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 274, Issue 2 43-2, 1998, Pages

  Dumaine, R ^a,b   Kirsch, G E ^a,c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASONIC MEDICAL RESEARCH LABORATORY   (United States)

^c METROHEALTH MEDICAL CENTER   (United States)

Author keywords

Cardiac arrhythmia; Human heart; Romano Ward syndrome; SCN5A

Indexed keywords

ANTIARRHYTHMIC AGENT; ION CHANNEL; LIDOCAINE; MEXILETINE; SODIUM CHANNEL; SODIUM ION;

ANIMAL CELL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ELECTROCARDIOGRAM; HEART ARRHYTHMIA; LONG QT SYNDROME; NONHUMAN; OOCYTE; PRIORITY JOURNAL; XENOPUS;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; CHROMOSOMES, HUMAN, PAIR 3; ELECTRIC CONDUCTIVITY; FEMALE; GENE DELETION; GENE EXPRESSION; HEART VENTRICLES; HUMANS; LIDOCAINE; MUTAGENESIS, SITE-DIRECTED; MUTATION; MYOCARDIUM; OOCYTES; RECOMBINANT PROTEINS; SODIUM CHANNELS; TRANSFECTION; XENOPUS;

EID: 0031913382     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.274.2.h477     Document Type: Article

References (35)

1. Adaniya, H., H. Hayami, M. Hiraoka, and T. Sawanobori. Effects of magnesium on polymorphic ventricular tachycardia induced by aconitine. J. Cardiovasc. Electrophysiol. 24: 721-729, 1994.
2. + channels. Circ. Res. 79: 103-108, 1996.
3. Attwell, D., I. Cohen, D. Eisner, M. Ohba, and C. Ojeda. The steady state TTX-sensitive ("window") sodium current in cardiac Purkinje fibres. Pflügers Arch. 379: 137-142, 1979.
4. Bean, B. P., C. J. Cohen, and R. W. Tsien. Lidocaine block of cardiac sodium channels. J. Gen. Physiol. 81: 613-642, 1983.
5. + channels. Circ. Res. 77: 584-592, 1995.
6. Bennett, P. B., K. Yazawa, N. Makita, and A. L. George, Jr. Molecular mechanism of an inherited cardiac arrhythmia. Nature 376: 683-685, 1995.
7. + channels. Biophys. J. 69: 873-882, 1995.
8. + concentration. Clin. Exp. Pharmacol. Physiol. 18: 533-541, 1991.
9. Carmeliet, E. Slow inactivation of sodium current in rabbit cardiac Purkinje fibres. Pflügers Arch. 408: 18-26, 1987.
10. Curran, M. E., I. Splawski, K. W. Timothy, E. D. Green, G. M. Vincent, and M. T. Heating. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80: 795-803, 1995.
11. Davidenko, J. M., L. Cohen, R. Goodrow, and C. Antzelevitch. Quinidine-induced action potential prolongation, early afterdepolarizations, and triggered activity in canine Purkinje fibers. Effects of stimulation rate, potassium, and magnesium. Circulation 79: 674-686, 1989.
12. Drewe, J. A., H. A. Hartmann, and G. E. Kirsch. Potassium channels in mammalian brain: a molecular approach. In: Ion Channels of Excitable Cells, edited by T. Narahashi. San Diego, CA: Academic, 1994, vol. 19, p. 243-260. (Methods Neurosci.)
13. + channel-linked long-QT syndrome. Circ. Res. 78: 916-924, 1996.
14. El-Sherif, N., R. H. Zeiler, W. Craelius, W. B. Gough, and R. Henkin. QTU prolongation and polymorphic ventricular tachyarrhythmias due to bradycardia-dependent early afterdepolarizations. Circ. Res. 63: 286-305, 1988.
15. Gellens, M. E., A. L. George, Jr., L. Chen., M. Chahine, R. Horn, R. L. Barchi, and R. G. Kallen. Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel. Proc. Natl. Acad. Sci. USA 89: 554-558, 1992.
16. Gintant, G. A., N. B. Datyner, and I. S. Cohen. Slow inactivation of a tetrodotoxin-sensitive current in canine cardiac Purkinje fibers. Biophys. J. 45: 509-512, 1984.
17. + channel inactivation gating. Circ. Res. 57: 114-122, 1994.
18. Hondeghem, L. M. Interaction of class I drugs with the cardiac sodium channel. In: Antiarrhythmic Drugs, edited by E. M. Vaughan Williams. Berlin: Springer-Verlag, 1989, p. 157-174.
19. Hondeghem, L. M., and B. G. Katzung. Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim. Biophys. Acta 472: 373-398, 1977.
20. Kaseda, S., R. F. J. Gilmour, and D. P. Zipes. Depressant effect of magnesium on early afterdepolarizations and triggered activity induced by cesium, quinidine and 4-aminopyridine in canine cardiac Purkinje fibers. Am. Heart J. 118: 458-466, 1989.
21. Kiyosue, T., and M. Arita. Late sodium current and its contribution to action potential configuration in guinea pig ventricular myocytes. Circ. Res. 64: 389-397, 1989.
22. Neher, E. The charge carried by single channel currents of rat cultured muscle cells in the presence of local anesthetics. J. Physiol. (Lond.) 339: 663-678, 1983.
23. + channel in guinea-pig ventricular myocytes. Pflügers Arch. 431: 101-109, 1995.
24. Ono, M., A. Sunami, T. Sawanobori, and M. Hiraoka. External pH modifies sodium channel block by mexiletine in guinea pig ventricular myocytes. Cardiovasc. Res. 28: 973-979, 1994.
25. Patlak, J. B., and M. Ortiz. Slow currents through single sodium channels of the adult rat heart. J. Gen. Physiol. 86: 89-104, 1985.
26. Roden, D. M., and B. F. Hoffman. Action potential prolongation and induction of abnormal automaticity by low quinidine concentrations in canine Purkinje fibers. Relationship to potassium and cycle length. Circ. Res. 56: 857-867, 1985.
27. Kr potassium channel. Cell 81: 299-307, 1995.
28. Sarkar, G., and S. S. Sommer. The "megaprimer" method of site-directed mutagenesis. Biotechniques 8: 404-407, 1990.
29. Schreibmayer, W., H. A. Lester, and N. Dascal. Voltage clamping of Xenopus laevis oocytes utilizing agarose-cushion electrodes. Pflügers Arch. 426: 453-458, 1994.
30. Schwartz, P. J., E. H. Locati, C. Napolitano, and S. G. Priori. The long QT syndrome. In: Cardiac Electrophysiology: From Cell to Bedside (2nd ed.), edited by D. P. Zipes and J. Jalife. Philadelphia, PA: Saunders, 1995, p. 788-811.
31. VanDongen, A. M. J. A new algorithm for idealizing single ion channel data containing multiple unknown conductance levels. Biophys. J. 70: 1303-1315, 1996.
32. + channel mutations in the congenital long QT syndrome. Proc. Natl. Acad. Sci. USA 93: 13200-13205, 1996.
33. Wang, D. W., K. Yazawa, N. Makita, A. L. George, Jr., and P. B. Bennett. Pharmacological targeting of long QT mutant sodium channels. J. Clin. Invest. 99: 1714-1720, 1997.
34. Wang, Q., M. E. Curran, I. Splawski, T. C. Burn, J. M. Millholland, T. J. VanRaay, J. Shen, K. W. Timothy, G. M. Vincent, T. de Jager, P. J. Schwartz, J. A. Towbin, A. J. Moss, D. L. Atkinson, G. M. Landes, T. D. Connors, and M. T. Keating. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat. Genet. 12: 17-23, 1996.
35. Wang, Q., J. Shen, I. Splawski, D. Atkinson, L. Zhizhong, J. L. Robinson, A. J. Moss, J. A. Towbin, and M. T. Keating. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell 80: 805-811, 1995.