Stepwise mechanism of hydroxide ion catalyzed cyclization of uridine 3′-thiophosphates

Helvetica Chimica Acta

Volumn 94, Issue 9, 2011, Pages 1563-1574

  Ora, Mikko ^a   Hanski, Anne ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

Catalysis; Cyclization reactions; Uridine 3 thiophosphate esters

Indexed keywords

ALKYL ESTERS; ARYL ESTERS; BREAKPOINT; CYCLIZATION REACTIONS; DIASTEREOISOMERS; HYDROXIDE IONS; LEAVING GROUPS; PHOSPHORANES; PHOSPHOROTHIOATES; PRODUCT DISTRIBUTIONS; RATE-LIMITING STEPS; SECOND-ORDER RATE CONSTANTS; THIOPHOSPHATE ESTERS; TIME-DEPENDENT;

CATALYSIS; ESTERIFICATION; ESTERS; RATE CONSTANTS;

CYCLIZATION;

2 ETHOXYETHYL URIDINE 3' PHOSPHOROTHIOATE; 2,2 DICHLOROETHYL URIDINE 3' PHOSPHOROTHIOATE; 2,2,2 TRICHLOROETHYL URIDINE 3' PHOSPHOROTHIOATE; HYDROXIDE; ISOPROPYL URIDINE 3' PHOSPHOROTHIOATE; PHOSPHOROTHIOIC ACID; UNCLASSIFIED DRUG; URIDINE; URIDINE 2',3' CYCLIC THIOPHOSPHATE; URIDINE 3' THIOPHOSPHATE;

ARTICLE; CHEMICAL REACTION KINETICS; CYCLIZATION; DIASTEREOISOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; PRIORITY JOURNAL; SYNTHESIS; TRANSESTERIFICATION;

EID: 80052858912     PISSN: 0018019X     EISSN: 15222675     Source Type: Journal    
DOI: 10.1002/hlca.201100115     Document Type: Article

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